0 antall prosjekter

FORINFRA-Nasj.sats. forskn.infrastrukt

Participation of NOR-OPENSCREEN in the Nordic Chemical Biology Consortium (NCBC) and the ESFRI project EU-OPENSCREEN.

Chemical Biology (CB) is defined as exploring biology by the use of small organic molecules and natural compounds. There is an increasing need for new bioactive compounds in many fields of Life Sciences and bioactive chemical compounds constitute the most common form of medical therapies and are ...

Tildelt: kr 0,25 mill.

Prosjektperiode: 2015-2016

Sted: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Compounds that regulate phospholamban phosphorylation with possible cardioprotective effect in the post-infarction heart

Successful acute trombolytic treatment of myocardial infarction (MI, 1.2 mill cases i 7 markets) creates more damaged hearts and a medical need for better post-MI treatment. The adrenalin-beta-adrenergic receptor-cAMP-protein kinase A signalling pathway r egulates heart rate and contractility. Al...

Tildelt: kr 5,8 mill.

Prosjektperiode: 2013-2017

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Role of phosphatases in the regulation of mitotic exit

-I dette prosjektet skal vi undersøke hvordan celler deler seg. Streng kontroll med celledelingsprosessen er avgjørende for å unngå utvikling av kreft. I mange år har fokus vært på en gruppe av proteiner kjent som cyklin-avhengige kinaser, som fungerer som en motor for å drive celledeling. Disse ...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2012-2015

Sted: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Development of technology for flow cytometry- and other cell-based, high-content, high-throughput analyses to support marine bioprospecting

ChemBioNet Norway - Norwegian Chemical Biology Platforms is a national network of HTS screening platforms (part of ESFRI-project EU-Openscreen) that support marine bioprospecting and drug screening. A joint application to the Infrastructure Programme for investments to support marine bioprospect...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2011-2015

Sted: Oslo

FORINFRA-Nasj.sats. forskn.infrastrukt

Participation of ChemBioNet Norway NOR-OPENSCREEN in ESFRI-preparatory phase project EU-OPENSCREEN

Chemical Biology (CB) is defined as exploring biology by the use of small organic molecules and natural compounds. There is an increasing need for new bioactive compounds in many fields of Life Sciences and bioactive chemical compounds constitute the most common form of medical therapies and are...

Tildelt: kr 0,49 mill.

Prosjektperiode: 2011-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Functional in vivo analysis of Protein Kinase Cs and related kinases

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Tildelt: kr 7,4 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIBIO-Biologi og biomedisin

3rd International Conference on Compartmentalized cAMP Signaling (jointly with FEBS Workshop on Spatiotemporal Dynamics of Cell Signaling)

There is a need for European and international scientists in the area of cell signaling to get together and bring attention to new subjects such as spatiotemporal organization, compartmentalized cAMP and modeling of signaling. Furthermore, European scient ists should get together for networking t...

Tildelt: kr 0,15 mill.

Prosjektperiode: 2010-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Spatiotemporal Regulation of cAMP Signalling in Health and Disease

Signalling networks involving the signal molecule cAMP and protein kinase A (PKA) are involved in regulation of a multitude of body functions involving most organ systems of the body. An emerging principle is that function of the cAMP signal pathway in th ese settings requires subcellular anchori...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

IS-DAAD-Forskerutveksl. Norge-Tyskland

Leitges, Michael, DAADppp 2009-10 Tysk-norsk forskerutveksling

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Tildelt: kr 0,12 mill.

Prosjektperiode: 2009-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

B-cell lymphomagenesis in Ung-deficient mice: collaboration between chronic antigenic stimulation and DNA repair deficiency

The importance of responding appropriately to DNA damage is highlighted by the frequent development of human disease, most notably cancer, in cells where this response is compromised. Here, we ask whether endogenous DNA damage, such as uracil in DNA, can contribute to activation of the DNA damage...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Towards a systems level understanding of responses to endogenous DNA damage in Caenorhabditis elegans

The impact of genomic instability on human health underscores the importance of understanding the mechanisms that coordinate responses to DNA damage in order to preserve genomic stability. There is a disparity between our knowledge of the cellular respons es to endogenous DNA damage and the impac...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FRIBIO-Biologi og biomedisin

Workshop on Dynamics of Cell Signal Systems (cofunded with FEBS)

There is a need for European and international scientists in the area of cell signaling to get together and bring attention to new subjects such as spatiotemporal organization and modeling of signaling. Furthermore, European scientists should get togethe r for networking to strengthen and increa...

Tildelt: kr 0,15 mill.

Prosjektperiode: 2008-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

A node of the FUGE platform for proteomics at the Biotechnology Centre of Oslo

Specialized proteomics service will be provided by the node at the Biotechnology Centre of Oslo for i.) quantitative proteomics ii.) clinical proteomics, and iii.) cell death proteomics. Quantitative proteomics will be performed either in cell culture by stable isotopic labeling of amino acids du...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

YFF-Yngre, fremragende forskere

Physiological and pathological impacts of glutamine transporters

Glutamine, the most abundant amino acid in the blood, is involved in a variety of metabolic processes such as biosynthesis of other substrates (eg proteins, nucleotides and amino sugars). It is also required for rapid cell growth such as in neoplasi. We h ave identified a family of amino acid tra...

Tildelt: kr 10,0 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

Drug targeting of protein-protein and ligand-protein interactions

Chemical biology (CB) involves use of small molecules to perturb and study biological function. Small molecular compounds (SMC) with molecular weight below 500 Da have proven extremely important to explore function at the molecular, cellular, and in vivo level and for treating diseases. Most medi...

Tildelt: kr 7,2 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

TU-Tungt utstyr

High resolution multi-dimensional imaging of cell signalling networks.

The Biotechnology Centre of Oslo (BiO) at the University of Oslo is a centre for functional genomics, currently consisting of six internationally competitive research groups headed by Drs. Taskén, Nilsen, Thiede, Chaudhry, Donaldson and Leitges. BiO also has an open position for a seventh new gro...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2007-2007

Sted: Oslo

FRIBIO-Biologi og biomedisin

Functional genetic networks that maintain genomic stability in mammalian cell lines and in Caenorhabditis elegans

The spontaneous formation of lesions in DNA is among the most significant threats to genomic integrity. We are using genetic and biochemical methods in the model organism Caenorhabditis elegans (C.elegans) and DNA repair deficient mouse cell lines to stud y the biological consequences of accumula...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional Genomics of Regulatory T cells - Novel Therapeutic Strategies for Immunomodulation

The main goal of the research plan is to understand how the immune system controls immune reactivity and balances self-tolerance versus an efficient immune defence. This could potentially lead to new understanding of key factors in the pathogenesis of hum an disease. Specifically, we aim to inves...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Modulation of a PKA-Csk-Lck inhibitory pathway in T cell lipid rafts by CD28-mediated recruitment of a b-arrestin/phosphodiesterase complex

The goal of this project is to understand the molecular mechanisms for cAMP inhibition of lymphocyte proliferation and immune functions. Specifically, we want to understand the molecular interactions and spatio-temporal regulation of the newly mapped PKA- type I-Csk inhibitory pathway regulating ...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

FUNCTIONAL SIGNIFICANCE OF INTRACELLULAR REGULATION OF GLUTAMINE TRANSPORTERS IN NORMAL AND MALIGNANT CELLS

Glutamine, the most abundant amino acid in plasma and cerebrospinal fluid, is important for many metabolic processes, e.g. biosynthesis of amino acids, purines and pyrimidines. Glutamine is a major N- and C-donor involved in inter-organ and inter-cellular shuttling of metabolites. It is a signal...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Novel therapeutic strategies for immunostimulation in HIV targeting CD25+ T-regulatory cells.

Regulatory T cells (Treg) represent 5-10% of the CD4 T cells and are identified by constitutively expressing CD25. Treg are subdivided into naturally occuring Treg devolped in the thymus, and adaptive Treg that are induced in the periphery from naïve CD4 T cells. Naturally occuring Treg are intst...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2008

Sted: Oslo

IS-STP-Statsstipendprogram, utlendinger

Palma Batista; Luis M., Portugal. STP05/06

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Tildelt: kr 15 000

Prosjektperiode: 2005-2006

Sted: Oslo

KREFTSATS-Særutlysning kreftmidler, historikk

Novel therapeutic strategies for stimulation of anti-neoplastic immune activity

More than 20% of the human genome encodes proteins that are devoted to cellular signalling. Signal networks that involve the signal molecule cyclic AMP (cAMP) are involved in diseases such as cancer, cardiovascular disease, type II diabetes, obesity, HIV and asthma. Cyclic AMP acts as an acute in...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

BIOFYS-Fysiologiske og anatomiske fag

ELECTROPHYSIOLOGICAL CHARACTERIZATION OF TWO GLUTAMINE TRANSPORTERS IN HETEROLOGOUS EXPRESSION SYSTEMS AND IN VIVO

We have molecularly identified SN1, a glutamine transporter, and demonstrated its capability of releasing glutamine at physiological conditions. The translocation of glutamine by SN1 is energized by coupling to Na+ in symport and H+ in antiport. Such elec troneutral transport allows the transport...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

RNA interference targeting Tissue Factor, a novel principle for cancer therapy.

The principal goal of this project is to explore the use of RNA interference (RNAi) technology in cancer therapy using Tissue Factor (TF) as a target. The project is based upon recent advances in RNAi technology and in our understanding of the role of TF in cancer cell biology. The cloning of T...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FORNY-3-Kommersialisering av FoUresultater

Development of specific PKA-type I and type II anchoring disruptors as drug candidates

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Tildelt: kr 0,50 mill.

Prosjektperiode: 2005-2005

Sted: Oslo

YFF-Yngre, fremragende forskere

Toppforskningsprogrammets prosjekt ledet av Kjetil Tasken

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Tildelt: kr 4,2 mill.

Prosjektperiode: 2004-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Søknad om støtte til ESF 2005 European Functional Genomics Conference

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Tildelt: kr 0,34 mill.

Prosjektperiode: 2004-2007

Sted: Oslo

FRIBIO-Biologi og biomedisin

Regulation of Protein Kinase C (PKC) membrane targeting and PKC-mediated activation of phosphatases

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Tildelt: kr 1,9 mill.

Prosjektperiode: 2004-2009

Sted: Oslo

COSTINF-COST Infrastruktur

Cost aksjon 725 Fenologi - reiseutgifter norsk samling

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Tildelt: kr 39 388

Prosjektperiode: 2004-2007

Sted: Oslo