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Dato fra ny til gammel

FRIBIO-Biologi og biomedisin

Elucidation of downstream signaling events of cAMP using new tools distinguishing the roles of EPAC and PKA

The present project will receive Epac and PKA modulating cAMP analogs. I. We will test selected new analogs in a newly developed and unique assay for binding to PKA holoenzyme II. The best activators (current or novel) will be used, separately and jointl y, to define effect of Epac and PKA activ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular control of differentiation of multipotent stem cells in simple marine animals

The maintenance of stem cells and the regulation of their differentiation are still poorly understood. Interstitial stem cells are easily accessible in the simple animal Hydra and give rise to different neuronal cell fates, gametes and gland cells. In con trast, no interstitial stem cells have be...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2013

Sted: Ukjent Fylke

FRIBIO-Biologi og biomedisin

The role of normal neighbouring keratinocytes and fibroblasts on clonal expansion of oral cancer (stem) cells

Recent studies, including ours, have shown that the invasive behaviour of cancer cells is not solely due to mechanisms intrinsic to the individual tumour cell. Genetic changes of individual cells in a specific tissue are not sufficient for invasive cancer to develop. Rather, there is a vivid cro...

Tildelt: kr 1,1 mill.

Prosjektperiode: 2007-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Electrical signaling in thin dendrites and axons in the cortex

A major challenge in neuroscience is to understand the mechanisms of neuronal computation, much of which is carried out by electrical signals generated by ion channels in the cell membrane. Within the last decade, advances in patch-clamp and imaging techn iques have extended our knowledge of such...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

cAMP signalling -novel downstream targets of PKA and Epac identified by phospho-proteomics.

I. Implement novel method for quantitative COFRADIC non-gel global phospho-proteomics through stay of candidate in the laboratory of prof. J. Vandenkerckhove at Univ. of Gent II. The phospho-proteome will be compared in cells in response to activation of PKA (by N6-MB-cAMP) or Epac (by 8-pCPT-2´-...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIBIO-Biologi og biomedisin

Contact meeting for the Norwegian Biochemical Society

The annual meeting of the Norwegian Biochemical Society has a world-wide reputation as an excellent meeting place for scientists, both on the scientific and the social level. They have been a tremendous success and is arguably the one meeting in Norway wh ich has contributed the most to the conta...

Tildelt: kr 0,36 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The ecological and evolutionary significance of seed banks in Arabidopsis thaliana

Many studies of the genetic structuring of annual, selfing Arabidopsis thaliana populations on various geographical scales have been performed in recent years. Some studies conclude that local populations may contain relatively high amounts of genetic var iability both in phenotypic traits and pu...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2012

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Mechanism of cargo selectivity in axonal transport Isolation and characterization of kinesin light chain associated vesicles

The aim of this project is to gain knowledge about how the motor protein kinesin-I interacts with its vesicle cargo, and what the nature is of the vesicles that are transported by kinesin-I through neurons. The role of neuronal transport in neurodegenerat ive diseases such as Alzheimer's disease,...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Rogaland

FRIBIO-Biologi og biomedisin

Dynamics underlying astrocyte behaviour

For a long time astrocytes, the most abundant glial cell species, have been considered passive bystanders of neural activity. The picture that is now emerging is that astrocytes are critically involved in regulating brain function. Despite extensive exper imental efforts, a thorough understanding...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2009

Sted: Akershus

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular and cellular mechanisms of the hippocampal memory system studied by in vivo recording in behaving animals

A major challenge in neuroscience is to explain behaviour in terms of molecular, cellular and neuronal network mechanisms. We will study mechanisms of the medial temporal lobe memory system by in vivo recording of hippocampal single unit and neuronal netw ork activity (EEG) in freely mowing rats ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FRIBIO-Biologi og biomedisin

Functional genetic networks that maintain genomic stability in mammalian cell lines and in Caenorhabditis elegans

The spontaneous formation of lesions in DNA is among the most significant threats to genomic integrity. We are using genetic and biochemical methods in the model organism Caenorhabditis elegans (C.elegans) and DNA repair deficient mouse cell lines to stud y the biological consequences of accumula...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Studies of growth control and gene expression in normal and neoplastic B-lymphoid cells

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. The complex biology and the variety of genetic and epigenetic factors involved in the pathogenesis make lymphomas a challenging disease for translational resear ch. There a clear need for the developmen...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2006-2012

Sted: Oslo

FRIBIO-Biologi og biomedisin

Interplay between DNA repair mechanisms in yeast and their crosstalk with other cellular processes

DNA repair is essential for the maintenance of genomic integrity and defect repair is associated with diseases as cancer, neurological disorders and aging. Unraveling the mechanism of DNA repair is therefore of fundamental importance and the present proje ct seeks to broaden our understanding of ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Endocytosis and intracellular transport of protein toxins

Errors in trafficking and signalling are associated with different diseases, including cancer. This project aims at increasing our knowledge about intracellular transport processes to provide a more rational basis for treatment and prevention of disease. Protein toxins such as Shiga toxin and the...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

The properties of thin, unmyelinated axons in mammalian brain

In order to better understand and control how neurons work we need more knowledge about thin, unmyelinated axons because: * They are the most common, but yet the least studied axonal type in the mammalian cortex. * They are the most excitable part of the neuron and are, therefore, very important ...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Spatiotemporal dynamics of introduced bark beetles: resource competition, invasion risk and management

The movement and establishment of invasive species in new habitats is a global economic and ecological problem. The increased trade among countries and continents has increased the chances of introductions of new species. Once alien pest species have beco me established in their new habitats, the...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

FRIBIO-Biologi og biomedisin

Functional characterisation of AlkB-like macromolecular demethylases

We have recently discovered a novel mechanism for repairing methylation damage in DNA and RNA. The repair reaction occurs by oxidative demethylation, and can be performed both by human and bacterial AlkB proteins. Eight different AlkB-like proteins are fo und in the human genome, and the project ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Chromatin and differential gene regulation: The role of adjacent PHD fingers and bromo domains in epigenetic regulators

Correct differential gene expression is essential for proper development of tissues and organs. While the initial patterns of gene expression are established by classical transcription factors, the maintenance of correct gene expression relies on epigenet ic mechanisms, one of which relies on dif...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2006-2011

Sted: Vestland

FRIBIO-Biologi og biomedisin

Protein - DNA interactions at atomic levels

The project aims at exploring protein-DNA interactions at atomic levels using novel DNA-binding proteins. Protein targets will be selected from the genomes of the extremophiles Deinococcus radiodurans and Vibrio salmonicida and produced recombinant in qua ntities necessary for structural and func...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2011

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The study of translocation of extragenous growth factors into cells- mechanisms and biological function of intracellular growth factors.

The growth, development and repair of cells and organs are controlled by a variety of hormones, growth factors and cytokines. Many of these factors are proteins that bind to specific molecules (receptors) at the cell surface. These receptors reside in the plasma membrane. Lipid membranes control...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Surviving without oxygen - from heart function to DNA replication

While most vertebrates die within minutes of anoxia (no oxygen), a few species can tolerate anoxia about 1000 times longer. These include the crucian carp (Carassius carassius, No: karuss), a common fish in Norway, and some turtles. Anoxia and ischemia related diseases are the major killers in ...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

NEURONES FORMING FUNCTIONAL NETWORKS IN THE MOTH BRAIN

We are searching to uncover the neuronal network involved in chemosensory coding and appetitive learning in insects, using moths of the subfamily Heliothinae as model organisms. The focus in the present project is to characterise physiologically and morph ologically neurones in the primary and th...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Modulation of a PKA-Csk-Lck inhibitory pathway in T cell lipid rafts by CD28-mediated recruitment of a b-arrestin/phosphodiesterase complex

The goal of this project is to understand the molecular mechanisms for cAMP inhibition of lymphocyte proliferation and immune functions. Specifically, we want to understand the molecular interactions and spatio-temporal regulation of the newly mapped PKA- type I-Csk inhibitory pathway regulating ...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Molecular Pathogenetic Mechanisms of Heart Failure - Dissecting GRK Function in The Heart

Heart failure, the final outcome of many cardiovascular disorders, is a major cause of morbidity and mortality in the Western Hemisphere. Indeed, the incidence and prevalence of heart failure in the Western Hemisphere are increasing due to altered demogra phics with increased proportion of elderl...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

The role of regulatory T cells in allergy

A dramatic increase in prevalence of allergy observed within the last two decades has been associated with better hygiene, increased use of antibiotics and improved vaccination. Infections are important for the induction of regulatory elements within the immune system, and it has been suggested t...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Degradation of insoluble carbohydrate polymers: how do microbial chitinolytic machineries work?

Enzymatic degradation of abundant insoluble carbohydrate polymers such as cellulose and chitin is of tremendous biological and biotechnological importance. Microbes produce numerous enzymes to hydrolyze these polymers, but the question of how they manage to disrupt the crystalline structure of th...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2009

Sted: Akershus

FRIBIO-Biologi og biomedisin

Effect of environmental DNA exposure on bacterial adaptation rates

The increasing amount of DNA sequence data available reveals that horizontal gene transfer (HGT) events have been frequent in most bacterial species. This observation identifies HGT as a major driving force in bacterial evolution. Whereas many studies hav e addressed the dynamics and mechanisms o...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2010

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Opioidergic signaling mechanisms in pain and dependence: PET opioid receptor binding. I. animal studies.

We are all naturally dependent on opioids for our emotional health. The opioid system is activated during the experience of pain, and opioids are used as analgesia and for abuse. Intentionally, opioid analgesia in pain and opioid drug abuse are contrary t o each other, but there are several commo...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2009

Sted: Ukjent Fylke

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