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Dato fra ny til gammel

PSYKISK-Psykisk helse

Longitudinal MRI Studies of Brain Morphology in Schizophrenia and Bipolar Disorder: Etiological Risk and Genetic Association.

Schizophrenia is often considered being a neurodevelopmental disease. The phenotype is heterogeneous with high heritability (80%) and unknown etiology and pathophysiology. Morphological brain abnormalities appear to be intrinsic features of the disease. I n previous scientific studies, abnormalit...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cytokine- and stress-induced myocardial hypertrophy

Myocardial hypertrophy can be induced through hormonal factors or stress-sensing molecules. Hence, it is necessary to study the activation and function of such hypertrophic mediators to completely understand the biological processes occurring during devel opment of heart failure. We will combine ...

Tildelt: kr 6,3 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Development of new technology for improving risk assessment of intracranial aneurysms using computer simulation models

Subarachnoid hemorrhage is a life threatening condition, caused by rupture of an intracranial aneurysm. Unruptured aneurysms are often found incidentally, making prophylactic treatment an option. Currently, risk-assessment of unruptured aneurysms is not s pecific enough for decision making in man...

Tildelt: kr 1,00 mill.

Prosjektperiode: 2008-2011

Sted: Troms - Romsa - Tromssa

NEVRONOR-Nasjonal satsing på nevrovitenskap f

TOP Group in Psychiatric Genetics Consortium - Genome Wide Association Study

Schizophrenia (SCZ) and Bipolar disorder (BIP) are severe psychiatric disorders characterized by psychotic symptoms, cognitive dysfunction and poor outcome, and are major public health problems with a high cost for society. The heritability is high, but d espite the clear genetic component, the p...

Tildelt: kr 0,30 mill.

Prosjektperiode: 2008-2009

Sted: Oslo

PSYKISK-Psykisk helse

Long term effects of early intervention in psychosis: Ten year follow-up of the TIPS study.

Mental illness is now the largest cause of disability in the developed countries, and schizophrenia is ranked among the leading causes of the total burden of disease worldwide. In addition to personal suffering, the disorder also represents a major proble m to society In spite of more than 75 000...

Tildelt: kr 1,9 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Molecular interactions and signalling mechanisms of 5-HT4 and 5-HT7 serotonin receptors

The basis for the current project is observations in our lab indicating special properties of two serotonin receptors, 5-HT4 and 5-HT7. First, we have demonstrated that the 5-HT7 receptor behaves as if it were preassociated with G protein in the absence of ligand and reduces the signalling capac...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

GLOBHELS-Global helse

2nd generation Vaccibodies for infectious diseases

Aim: PI (Bjarne Bogen) and co-workers have recently reported on a novel vaccine technology, Vaccibodies, which appears very potent. The object of the present proposal is to further improve the design and immunogenicity of Vaccibodies (resulting in 2nd gen eration Vaccibodies). Background: New an...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular basis for control of the heartbeat by Na+

Contraction of the heart is triggered by an increase in Ca2+ within cardiac muscle cells, as Ca2+ ions bind to contractile proteins. The rise in Ca2+ results primarily from release from the sarcoplasmic reticulum which is the main intracellular store of C a2+. Therefore, the pumping ability of th...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

FOLKEHELSE-Folkehelse

Physical activity, obesity, gestational diabetes and type 2 diabetes in pregnancy, short and long term outcomes in a multiethnic population

Background The life course approach may be a rational manner to study the epidemic of obesity and type 2 diabetes (T2DM) and to identify entry points for preventive measures. Gestational diabetes (GDM) is a risk factor for mother and child, and in additio n identifies a population of high risk fo...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Mitochondrial Health and Neuronal Life

Lars Eide and Magnar Bjørås are joint applicants for this project. Mitochondria have central roles in neuronal homeostasis as they actively participate in energy production, calcium buffering and apoptosis control. Erosion of mitochondrial function is th ought to underlie the progressive neurona...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Senter for rus- og avhengighetsforskning - SERAF

Tildelingen fra NFR har gjennom 10 år gjort det mulig for SERAF å utvikle og å drive klinikknær rusmiddelforskning på høyt internasjonalt nivå. Vi har bidratt til en bedre, kunnskapsbasert behandling av rus- og avhengighetslidelser i Norge, gjennom å bidra til et lokalt basert og forankret kunnsk...

Tildelt: kr 100,9 mill.

Prosjektperiode: 2007-2020

Sted: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Brain and brain cell injury in newborn infants

The main objective of the proposed project is to investigate basic mechanisms for regulation of brain injury and brain cell death in newborn infants. Specifically, we propose to study these mechanisms as they relate to two common causes of brain damage in the newborn period, namely asphyxia (hyp...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Dioxin-like Organohalogen Carcinogenesis

Dioxin-like organohalogens include polychlorinated dibenzodioxins, dibenzofurans and 11 planar bifenyls (PCB). In addition, brominated flame retardants (PCDE) may share many of their characteristics. They are persistent environmental pollutants which acc umulate in food chains. Human exposure oc...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Epigenetic surveying in immune-mediated diseases. A twin study.

Background: Genetically complex diseases, e.g. immune-mediated diseases are caused by a complex interplay between susceptibility genes and environment. The impact of environmental factors is clearly demonstrated in twin studies showing concordance rates i n MZ twins well below 100%. One impact of...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

SFF-Sentre for fremragende forskn

Centre for Cancer Biomedicine, CCB

Grunntanken bak dannelsen av CCB var å forene basalbiologisk forskning på mekanismer i kreftutvikling med pasientnær kreftforskning som tar sikte på å identifisere nye kjennetegn på kreft som kan brukes i diagnose, prognose og terapi. Dette har vist seg som en vellykket forskningsstrategi, og CCB...

Tildelt: kr 120,6 mill.

Prosjektperiode: 2007-2018

Sted: Oslo

PSYKISK-Psykisk helse

EARLY BIPOLAR DISORDER: CLINICAL AND BIOLOGICAL CHARACTERISTICS IN FIRST EPISODE MANIA

Bipolar disorder (BPD) is a severe psychiatric disorder characterized by manic and depressive episodes with periods of normal mood in between. Recent lines of evidence suggest that BPD is a more severe illness that previously believed and it is regarded as one of the most important factors contr...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

TU-Tungt utstyr

Magnetic resonance imaging and spectroscopy of small animals

Magnetic Resonance Imaging (MRI) offers unique opportunities to obtain in vivo information about organ structure and function. The technique is widely used in clinical research. This application from several research groups at Ullevaal University Hospital is primarily focussed on the neurobiolog...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

TU-Tungt utstyr

Identifikasjon av kreftrelevante gener ved storskalaanalyser

Cancer is a complex invasive-cell disease that operates in many disguises. To combat it efficiently, we need to integrate cancer-related biological information occurring at multiple levels - molecular, cellular, and organismal. Such a complex analysis, kn own as systems biology, is based on the t...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2007-2007

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Computational models of aberrant attribution of salience in schizophrenia and the effects of medication: An event related fMRI study

It has been known for decades that dopamine abnormalities are relevant to the pathophysiology of schizophrenia (mainly psychotic symptoms) and that blocking the dopamine system is associated with improvements in symptoms. How one gets from this neurochemi cal change to the expressed behavior abno...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

TU-Tungt utstyr

Imaging av metabolske prosesser

Ulike ytre faktorer og skadde proteiner påvirker metabolske prosesser i cellen og kan resultere i sykdom eller celledød. Ved institutt for klinisk biokjemi er vi interessert i å studere hvilke molekylære mekanismer som er årsak til metabolske sykdommer. S iden metabolske prosesser er dynamiske, e...

Tildelt: kr 1,2 mill.

Prosjektperiode: 2007-2008

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Medication assisted rehabilitation and crime; how do MMT affect crime rates and patterns?

It is still not known fully to which extent MMT offers crime reduction as a mean of harm reduction for heroin addicts in Norway. New knowledge of crime reduction patterns based on cross-registry studies and in-dept studies on crime patterns will give impo rtant new knowledge for program planners ...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

TU-Tungt utstyr

In vivo imaging (Xenogen IVIS 200) ved kreft og autoimmunitet

Kreftsykdommer,autoimmune sykdommer, hjertesykdom, transplantasjoner , krybbedød m.m er tilstander som forårsaker betydelige lidelser og tidlig død. Det er derfor viktig å finne årsak til disse sykdomstilstandene og utvikle bedre behandlingsformer. Gode dyremodeller er nødvendige for å oppnå sli...

Tildelt: kr 1,0 mill.

Prosjektperiode: 2007-2007

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Immunopathogenic mechanisms in coronary artery disease

Despite state of the art cardiovascular treatment, coronary artery disease (CAD) with development of acute coronary syndromes are still common manifestations of atherosclerosis, suggesting that important pathogenic mechanisms remain active and unmodified by the present treatment modalities. Based...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

INT-BILAT-BILAT-ordningen

Russia - Development of biosensors for detection of ischemia, graft rejection and inflammatary response

The first step in establishing a cooperation between the Russian and Norwegian anaesthesiology departments presented above, will be to send a promising Russian PhD candidate to Norway to evaluate whether one of the three projects outlined below are suitab le for a PhD thesis beneficial for both I...

Tildelt: kr 34 211

Prosjektperiode: 2007-2009

Sted: Oslo

GLOBHELS-Global helse

Novel vaccine candidates and delivery systems for HIV and influenza

Aim: We wish to generate novel vaccines for important infectious diseases such as HIV (FRIBIOMOL)and influenza (GLOBVAC). Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However, for some important diseases such as HIV, there are no available vacc...

Tildelt: kr 2,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

L-Ornithine and phenylacetate: A novel and effective therapy for hepatic encephalopathy

Background: The major therapeutic target for the treatment of hepatic encephalopathy is ammonia. Our extensive investigations in animal models and also in humans with cirrhosis support the view that the major organ removing ammonia in patients with cirrho sis is the muscle, converting ammonia to ...

Tildelt: kr 1,3 mill.

Prosjektperiode: 2007-2009

Sted: Troms - Romsa - Tromssa

FRIMED-Klinisk medisin og folkehelse

Improving Patient-Provider Communication in Cancer Care

Improving shared decision making (SDM)and patient-provider communication, and incorporating patients' illness experiences and preferences into patient care are high priority health policy goals. However, this is difficult to accomplish without methods and systems that assist patients in sharing ...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

Vaccine development for HIV and influenza

Aim: Based on the vaccibody principle developed by us, we wish to generate novel vaccines for important infectious diseases such as HIV and influenza. Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However , for some important diseases such as HIV...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular responses to meningococcal meningitis

Meningococcal disease is a leading cause of meningitis and septicaemia worldwide. Among the serious consequences of meningitis are brain edema and disturbed neuronal excitability. These effects are often the direct cause of death. Despite the serious comp lications, the molecular basis for these ...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

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