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Dato fra ny til gammel

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The complement system and the CD14/TLR4/MD2 complex as targets for therapy in sepsis.

Prosjektet tar sikte på å utvikle et nytt terapeutisk regime ved tilstander hvor det medfødte immunapparatet er over-aktivert og gir opphav til alvorlig sykdom, slik man ser det ved sepsis (blodforgiftning). Vi har i tidligere studier vist at hemming av to viktige grener av immunapparatet, komple...

Tildelt: kr 8,1 mill.

Prosjektperiode: 2011-2017

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Nutritional Programming of Adipose Tissue Functions; The use of Atlantic salmon as a model organism for obesity

Excessive fat deposition, bone deformities, and inflammatory diseases are important problems faced by the intensive aquaculture industries today. Although not known for fish, these problems may be linked to nutritional programming at early life stages. Mo st species studied have high number of un...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2011-2013

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Biomechanical characteristics of patients with hip osteoarthritis with mild to moderate pain: A prospective, randomized clinical trial

This project funding proposal concerns a personal postdoctoral fellowship within the area of clinical research. The project will investigate the effect of exercise therapy and patient education compared to patient education alone on lower extremity biomec hanics during gait, sit-to-stand, and one...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2011-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Localisation, regulation and functional significance of the SMC-loading complex during eukaryotic cell division.

The strucural maintenance of chromosome (SMC)-complexes organise and stabilise higher order chromosomal conformations during normal cell division, e.g. condensation of chromosomes cell division or generation of inactive chromatin, cohesion of newly replic ated sister chromatids and stabilisation ...

Tildelt: kr 1,5 mill.

Prosjektperiode: 2011-2015

Sted: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The adaptive evolution of arthropod and vertebrate aquaporins: Deciphering the differential basis of water homeostasis

Innledende studier fokusert på å identifisere de genomiske repertoar av akvaporiner i et bredt spekter av prokaryote og eukaryote organismer for å legge grunnlaget for å forstå den evolusjonære historien til superfamilen, og for å identifisere alle akvaporin gener i lakselusa og sin vert, den atl...

Tildelt: kr 9,6 mill.

Prosjektperiode: 2011-2015

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Arc and the molecular control of LTP consolidation in vivo

The brain extracts information about the world that shapes our behavior and ultimately influences who we are as individuals. The immense capacity and specificity of memory storage in the mammalian central nervous system is thought to depend on the plastic ity of synaptic connections. Recent break...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2011-2015

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Viral infections during early infancy, pregnancy and type 1 diabetes risk

Populærvitenskapelig framstilling - English version Norway is one of the countries with the highest incidence of the type 1 diabetes, which is a common, chronic autoimmune disease that usually manifests in childhood. There is a broad consensus that type 1 diabetes has a genetic and environmental...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2011-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Effectiveness of colorectal cancer screening on colorectal cancer incidence and mortality

Tildelt: kr 2,7 mill.

Prosjektperiode: 2011-2014

Sted: Telemark

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular alterations for targeting therapy in metastatic gynecologic cancer

Endometrial cancer is the most common and ovarian cancer the most lethal pelvic gynaecologic malignancies. Improved treatment for metastatic disease and reliable predictors for response to therapeutics are needed. Serous papillary endometrial- and ovarian carcinomas share an aggressive course of...

Tildelt: kr 9,2 mill.

Prosjektperiode: 2011-2016

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Collective behaviour of penned herring: Observing the collective behaviour and investigating the effect of various sound stimuli

Målet med prosjektet er å forstå samspelet mellom direkte stimuli og informasjonsoverføring mellom individ i ein fiskestim, og å forstå korleis dette påverkar den kollektive åtferda, med særlig vekt på støyindusert åtferd. I 2012 vidareutvikla vi ein metode for å observere fiskeåtferd frå mul...

Tildelt: kr 8,9 mill.

Prosjektperiode: 2011-2015

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Small RNAs and DNA repair in Mycobacterium tuberculosis adaptive responses

Tuberkulose (TB) er en av verdens mest utbredte infeksjoner, som tar nesten 1.3 millioner liv og forårsaker 8.7 millioner infeksjonstilfeller årlig. Årsaken er Mycobacterium tuberculosis (Mtb), som infiserer 1/3 av verdens befolkning og har forårsaket flere dødsfall enn noen annen mikrobe. Behand...

Tildelt: kr 3,8 mill.

Prosjektperiode: 2011-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Bio-Epidemiology of Fitness and Cardiovascular disease From Society to Molecules and back again

Tildelt: kr 9,4 mill.

Prosjektperiode: 2011-2015

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

CAUSES AND CONSEQUENCES OF FLUCTUATING SELECTION IN A STOCHASTIC ENVIRONMENT

I den foreliggende rapporteringsperioden nådde vi en viktig milepæl: 1. Price-Robertson ligningene representerer en av de viktigste bidragene til evolusjonsbiologien fordi de gir en metode for å beskrive evolusjonære endringer i kvantitative karakterer selv om den underliggende genetikken som k...

Tildelt: kr 12,9 mill.

Prosjektperiode: 2011-2015

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

cAMP-mediated regulation of proliferation and cell death in normal and malignant cells

I prosjektperioden 20111001-20161130 har vi publisert 8 artikler direkte knyttet til prosjektet. I prosjektet knyttet til effekten av cAMP på DNA-skadeindusert celledød i akutt lymfoblastiske leukemi-celler (ALL-celler), har vi vist at cAMP-signalering fører til reduserte nivåer av DNA-skadeindus...

Tildelt: kr 3,8 mill.

Prosjektperiode: 2010-2017

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Traffic through and around the Golgi apparatus in epithelia -determine the apical and basolateral surface glycoproteomes

The cell surface is decorated with glycans attached to lipids and proteins. Different plasma membrane regions display a specific composition of glycanated proteins and contribute to the definition of interactions at the cell boundary. For epithelial cells , glycans (particularly glycosaminoglycan...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

New transgenic mouse models for studies of integrin function in fibroblastic cells

Cells interact with the extracellular matrix via cell surface receptors called integrins. During the 10 past years we have systematically worked on one particular integrin that we have identified and characterized, the alpha11beta1 integrin. In 2007 we pu blished a paper describing a tooth erupti...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2010-2014

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

A longitudinal population study of infant vulnerability and plasticity from pregnancy to age 18 months

Prosjektet er en longitudinell studie hvor den overordnede målsettingen er å øke kunnskap om pre- og postnatale risikofaktorer for barns tidlige utvikling. Bakgrunnen for studien er behovet for å øke forståelsen av hvordan barn tidlig kan komme inn på forskjellige utviklingsveier, hvilke forhold ...

Tildelt: kr 12,4 mill.

Prosjektperiode: 2010-2017

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Characterization of the role of the small GTPase Rab7b in intracellular traffic.

Intracellular trafficking is regulated by Rab proteins. More than 60 human Rabs have been identified but until now there has been no Rab assigned to the transport from TGN to late endosomes/lysosomes. In our recent work (Progida et al, under revision), we show that Rab7b is a strong candidate fo...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2010-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

From clinical to molecular characterization of multiple sclerosis

Tildelt: kr 7,8 mill.

Prosjektperiode: 2010-2016

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Surviving without oxygen - from the role of hypoxia inducible factor to rebuilding a naturally damaged brain

While medical science has had a very limited success in counteracting the deleterious effects of ischemia/hypoxia in humans, evolution has repeatedly solved this problem. The best studied examples of anoxia tolerant animals are some North American freshwa ter turtles (genera Trachemys and Chrysem...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2010-2013

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: Community composition and gene expression of methane oxidising bacteria (methanotrophs) in high latitude terrestrial ecosystems:

Microbes are the catalysts and drivers of ecosystems on Earth. Despite their importance environmental microbial communities are not on the biodiversity conservation agenda. Nothing is known regarding the vulnerability and resilience of microbial communiti es a situation exacerbated by the inheren...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2010-2013

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Genome size, cell size and growth; searching for the causal links

We here aim both at exploring the causal links between growth rate, genome size and cell size and the evolutionary drivers for reduced genome size. There are likely several routes to genome size variability within and across taxa. Here, we are mainly inte rested in the observation that meiosis an...

Tildelt: kr 8,6 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Phytoplankton size: Climatic adaptation and long-term evolution

Tildelt: kr 4,5 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Roles of p62/SQSTM1 and novel ATG8-binding proteins in selective autophagy and cell signalling

Macroautophagy, here referred to as autophagy (greek: eating oneself), is a protein degradation pathway that involves lysosomal degradation of cytoplasm and organelles. Autophagy plays an important role in degradation of damaged organelles and toxic prote in aggregates which cannot be degraded by...

Tildelt: kr 6,3 mill.

Prosjektperiode: 2010-2013

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Tracking signatures of adaptive diversification during postglacial colonization: the build-up of genomic isolation in threespine stickleback

Trepigget stingsild er regnet som en opprinnelig marin art. Likevel har den invadert ferskvann gjentatte ganger etter den siste istid. Stingsild i ferskvann er ofte morfologisk forskjellig fra stingsild i sjøen; spesielt har de flere beinplater langs kroppssidene i saltvann enn i ferskvann. I en ...

Tildelt: kr 7,3 mill.

Prosjektperiode: 2010-2015

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Flexibility and constraints in animal movement patterns: ecology, evolution and annual cycles

Fuglearter har utviklet ulike strategier for storskala-forflytninger utenom hekkeperioden, og møter derfor ulike begrensinger i timing og fleksibilitet i forhold til mellomårsvariasjon og endringer i miljøet over tid. Gjennom fire ulike modellsystemer har vi plassert fenologi og forekomsten av in...

Tildelt: kr 10,8 mill.

Prosjektperiode: 2010-2015

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Clinical features of autism spectrum disorders

Prosjektet bygger på Den norske mor og barn-undersøkelsen (MoBa) og dens delstudie av autismespekterforstyrrelser, The Autism Birth Cohort study (ABC-studien). MoBa inkluderer 114 500 barn, og ABC-studien identifiserer og karakteriserer barn med autisme i nnenfor MoBa-kohorten. Prosjektbevilgning...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2010-2015

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Nuclear autophagy; Functions in neuroprotection and tumor suppression

Autophagy is a cytoplasmic renovation mechanism that causes degradation and clearance of macromolecules such as pathogens, defective organelles and protein aggregates. PML bodies, on the other hand, represent distinct nuclear compartments that are known t o function in apoptosis, differentiation ...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Functional in vivo analysis of Protein Kinase Cs and related kinases

Tildelt: kr 7,4 mill.

Prosjektperiode: 2010-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

DECIPHERING EMBRYONIC SEGMENTATION: GENES THAT CONTROL THE REPEAT PATTERN OF THE VERTEBRAL COLUMN

The segmented or metameric aspect of the body axis is a basic characteristic of vertebrates, and segmentation has long thought to be a key aspect of the basic design. Previous studies from our group have shown that the notochord of teleosts nucleates vert ebral development by forming the initial ...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2010-2015

Sted: Vestland

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