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EOSC Beyond: advancing innovation and collaboration for research

EOSC Beyond overall objective is to advance Open Science and innovation in research in the context of the European Open Science Cloud (EOSC) by providing new EOSC Core capabilities allowing scientific applications to find, compose and access multiple Open Science resources and offer them as integrated capabilities to researchers. To do so, EOSC Beyond supports a new concept of EOSC: a federated and integrated network of Nodes operated at different levels, national, regional, international and thematic, to serve the specific scientific missions of their stakeholders. Further specific objectives of the project are to accelerate ‘time to product’ of new scientific applications with software adapters, enable Open Science with machine composability and dynamic deployment of shared resources, support innovation in EOSC with a testing and integration environment, and align the EOSC Core architecture and specifications to integrate with European dataspaces. The project extends the state of the art of the EOSC Core and adopts a co-design methodology, including requirements elicitation, software development and validation in collaboration with different use cases from EOSC national and regional initiatives (e-Infra CZ, Czechia, NFDI, Germany, and NI4OS, South East Europe region), thematic research infrastructures from Social Sciences and Humanities (CESSDA), Life Sciences (CNB-CSIC and Instruct-ERIC), Environmental Science (ENES and LifeWatch), and Health and Food (METROFood-RI). EOSC Beyond builds on the capacities of prospective EOSC Nodes and partners with multi-annual experience in developing solutions for large-scale federated digital infrastructures and aligns with the technical architecture and requirements of data spaces from different business sectors. Ultimately, EOSC Beyond supports Open Science in modern, data-intensive, and multidisciplinary research, facilitating resource discovery, access, and reuse across scientific communities, organisations, and countries. 

CULTUral heritage in RurAL remote areas for creative tourism and sustainabilITY

The main objective of the project is to contribute to the promotion of cultural and creative tourism activities, considering the different capacities, resources, and specificities (material, creative, human...) of the territories, as a mean to help with the sustainable development of peripheral rural areas, favoring job creation and population settlement. For this, the potential of its cultural heritage will be researched, taking into account both the artisan material culture (techniques, materials, patterns and decorative elements), as well as the intangible culture (music, oral knowledge and culinary traditions) as a resource.   To promote non-seasonal tourism as a form of sustainable development with a stable population settlement we are going to research the crafts linked to the territory and their implications, but we will also carry out a documentation of the productive processes. First and foremost, we are going to cater to the necessities of the local communities and pay attention to aspects related to societal groups at risk of exclusion, such as women, the elderly and the youth.  All this will be developed from a multidisciplinary perspective, for which we will count on the various teams —most of them linked to different countries— that will be part of the consortium. Each of these partners will contribute to the development, as well as to the final result of the project through input directly related to their area of ??expertise: for example, among the collaborators we have intellectual teams specialized in the digitalization of heritage, research, or communication and dissemination, as well as as various institutions that will act as a testing ground for the more practical parts of the proposal. However, if something will characterize our work, it will be the constant collaboration between all parties, as well as the exchange of advice and experiences that will help to enrich collective knowledge and guarantee optimal results.

AQUASERV – RESEARCH INFRASTRUCTURE SERVICES FOR SUSTAINABLE AQUACULTURE, FISHERIES AND THE BLUE ECONOMY

The overarching objectives of AQUASERV are to bring together, enhance, integrate and customise RI capacities (including facilities, instruments and expertise) and through the provision of transnational access (on-site or remote) and/or virtual access, to significantly further scientific advance and promote and facilitate the implementation of European Common Fisheries Policy, the Farm to Fork Strategy, the Sustainable Blue Economy and the European Green Deal.   AQUASERV will achieve these objectives by offering scientists from academia and business remote and on-site transnational (TA) and virtual (VA) access to an advanced set of European research infrastructures and its nodes related to research and management of marine and freshwater biological resources, food and biotechnology. These include the European Marine Biological Resource Centre ERIC (EMBRC), the Analysis and Experimentation on Ecosystems ERIC, The Aquaculture for Excellence for Aquaculture in Fish (Aquaexcel), and the Infrastructure for Promoting Metrology in Food and Nutrition (METROFOOD), as well as the International Council for Exploration of the Sea, both a service provider and stakeholder. It also includes the Research Infrastructure for Science and Innovation Policy Studies (RISIS) to bring contributions from the social sciences and to bring results nearer to policy makers ensuring societal impact.   To enhance, integrate and customise RI capacities, collaboration between partners and new pipelines to meet the objectives of the project will be developed during the first 3 years and will make available  to users.  To ensure these capacities will not be lost, a sustainability work package involving stakeholders will address the project legacy.    To maximize impact, AQUASERV will build a communication network among the partnership and develop a dissemination and outreach programme. Furthermore, an advanced training programme will be developed to capture future users and will be updated during the p

Harmonization of Advanced Materials Ecosystems serving strategic Innovation Markets to pave the way to a Digital Materials & Product Passport

The overarching objective of DigiPass is to enhance the digital maturity of the European communities that develop materials and intermediate products. The project will develop recommendations and clear routes toward digitalized circular business models. The overarching key result of DigiPass is to create a sustainable platform which includes support for Digital Materials & Product Passport and for collaborative innovation-by-design processes in a circular economy served by advanced materials. A business model for operating such a platform completes the overarching objective. DigiPass is harmonizing and synergizing collected materials data sources and digital infrastructures. This will enable interoperability of data exchange, and standardization of advanced materials knowledge representation at all maturity levels. Accelerating the design, development, and production of advanced, safe, and sustainable chemicals and materials, as they are necessary for innovative products, calls for a collaborative approach involving different stakeholders to support durability, repair and overhaul, reuse, and recyclability of products. DigiPass project impacts all materials development communities over the whole circular value chain.  

EOSC-ENTRUST: A European Network of TRUSTed research environments

The mission of EOSC-ENTRUST is to create a European network of trusted research environments for sensitive data and to drive European interoperability by joint development of a common blueprint for federated data access and analysis.  Countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policy-driven analysis of sensitive datasets such as people's health and socio-economic status, the habitats of vulnerable species and geo-spatial locations of protected sites. There are now a large number of such secure environments in operation - linked to national centres, individual organisations or specific research communities. This fragmented landscape poses challenges for both users and providers: researchers are faced with a large number of different systems and access procedures; providers need to manage federated access across multiple, potentially incompatible, technology and governance frameworks. EOSC-ENTRUST brings together providers of operational Trusted Research Environments from 15 European countries with a shared goal to implement, validate and promote their capabilities through a common European framework using shared standards and common legal, operational and technical language. This blueprint for interoperability is anchored in the EOSC Interoperability Framework spanning the four dimensions of Legal, Organisational, Technical and Semantic interoperability. EOSC-ENTRUST has identified four driver projects covering Genomics, Clinical trials, Social science, and public-private partnerships to benchmark capabilities, inform blueprint design and demonstrate secure  data analysis using federated workflows. Targeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a long-term operational TRE framework within the European Open Science Cloud. 

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Strengthening resilience and mental wellbeing through the Support4Resilience toolbox for leaders in elderly care

European elderly care experiences labor shortages, lack of qualified workers and a mismatch between capacity and demands, causing stress, burnout, and reduced mental wellbeing among healthcare workers and informal caregivers. Leaders are crucial in promoting supportive working conditions but lack research-based measures to act upon these challenges.  Support4Resilience (S4R) will develop, implement, and evaluate a research-based Toolbox to support healthcare leaders in improving healthcare workers’ and informal caregivers’ resilience and mental wellbeing in elderly care. S4R will identify resilience and mental wellbeing factors among healthcare workers and informal caregivers; explore their perspectives and needs; develop new theory on the relationship between individual and organizational resilience, and mental wellbeing; and develop recommendations and cost-effective interventions. The Toolbox with tailormade resources for policy and practical use will be available through an open access S4R Resource Bank.  The S4R Toolbox includes three main tools: 1) Mapping and identification, 2) Reflection and education, and 3) Reorganization. Measures are initiated at the organizational level and effects on mental wellbeing and resilience transpire at the frontline of elderly care. The Toolbox covers different situational contexts, types of healthcare providers and health system levels. Elderly care settings in six European countries will implement and evaluate the Toolbox through a process evaluation, effectiveness evaluation, and cost-effectiveness evaluation.   S4R provides policymakers, decisions-makers and leaders with solutions for taking action to solve specific risks for healthcare workers’ and informal caregivers’ resilience and mental wellbeing. Thus, pertinent to the work programme, S4R will support the development of resilient health systems in European elderly care through improved leadership capabilities, governance structures, and adaptive capacities.

UNIVERSAL SENSOR BASED ON ELECTRICALLY-PUMPED MID-INFRARED SPECTROMETER ON SILICON CHIPS

High resolution optical spectroscopy in the mid-infrared (mid-IR) spectral range (3-12 µm wavelength) is an unambiguous way to detect and quantify small traces of greenhouse and toxic gases down to sensitivities of parts-per-billion. Such sensitivities are a prerequisite to safeguard low-pollution and toxic-free environment defined by the EU Action Plan: "Towards a Zero Pollution for Air, Water and Soil.” However, size, cost, and general complexity of the commercially available instruments limits their use to a small number of highly specialized applications, and prevents their deployment with sufficient coverage e.g. in networks, wearable electronics, etc. Particularly in the context of Internet of Things (IoT) devices, on chip integration of spectroscopic systems would constitute a game changer for mid-IR high-precision and portable sensors. The objective of UNISON is to address this challenge and demonstrate a highly scalable platform for infra-red spectroscopy that has both high-end performance and is compact. UNISON sensing scheme relies on dual comb spectrometers obtained by leveraging on electrically pumped cascade lasers (QCL and ICL) and on silicon-germanium (SiGe) mid-IR photonic circuits to surpass current spectroscopic systems in terms of detection bandwidth, point spacing and system compactness. UNISON is organized around 3 main cornerstones each of them relying on ambitious physical and technological challenges: (i) tunable large bandwidth frequency combs will be generated on SiGe photonics circuits  by combining electro-optical comb generation, non-linear effects and dispersion engineering ; (ii) the comb sources will be pumped by novel electrically-driven cascade laser sources integrated with the SiGe photonics circuits ; (iii) compact, broadband, and sensitive interaction region for trace gas detection, designed and optimized for the SiGe platform, will be integrated with the dual comb source to showcase the sensing capability of the spectrometer. 

Providing research infrastructure services to support Next Generation EU

This four-year project will harness outputs from key social science RIs in Europe and other reliable sources to support the aims of the ‘Next Generation EU’ programme and to inform EU youth policy. Virtual access will be provided to the outputs through special installations (portals) developed during the project. The core of the proposal is a set of existing research ‘services’, which will be re-purposed and customised to focus directly on the five themes: Make it Green; Make it Digital; Make it Healthy; Make it Strong; and Make it Equal.   For each area, the consortium will work collaboratively to produce seven sets of resources:  i)	A searchable inventory of relevant variables drawn from multiple cross-national datasets;   ii)	Analytical summaries, suitable for policy makers and analysts new to the field, as well as interactive resources available through the project portal;  iii)	Harmonised and merged extracts from these datasets that reduce the burden on analysts and increase sample sizes;  iv)	New data collected through the ESS’s established CRONOS web panel infrastructure. Eleven countries will field five waves of the panel, each one dedicated to a NextGenEU theme. Free and rapid access to the data will be available through the CRONOS portal alongside analytical summaries;  v)	In-person and virtual deliberative forums with young people (aged 18-34) in four countries covering the five Next Generation EU’ themes;  vi)	An educational tool (E-NextGen) channelling our data for use in classrooms and by the general public;  vii)	Comprehensive training materials related to all project outputs. 

Cooperation and AgReements enhancing Global interOperability for Aerosol, Cloud and Trace gas research infrastructures

The goal of CARGO-ACT is to deliver a clear roadmap for sustainable global cooperation between key ground-based aerosol, cloud and trace gas research infrastructures, each having invested in infrastructure and services to support their observing networks with a long-term perspective, with a view to consolidating into a sustainable global research infrastructure in the future. There is a strong desire for global integration from the research community, including weather, climate, and air quality monitoring and modelling,  and in particular from space agencies, since global networks of ground-based observations are an essential component complementing Earth Observation from space, providing calibration and validation of the remote sensing information collected by current and future satellite missions. The integration of the current ground-based networks, which may have different interests and priorities, requires cooperation and agreements at the global level, including engagement with relevant stakeholders. Their service provision is not limited to data services, but includes access to the measurement facilities, reference instruments, reference standards and laboratories, all of which are topics to be assessed in CARGO-ACT.    The specific objectives of CARGO-ACT are to, develop sustainable partnerships and decision making processes with relevant partners, demonstrate the benefits of converging interoperability and standards to stakeholders and the global research community, establish the mechanisms for providing  international access to distributed research infrastructures and develop a roadmap for upscaling towards an integrated global research infrastructure for aerosol, cloud and trace gases. 

Midlene fra FARM-Farmakologisk, farmasøytisk forskning fordelt på år

Midlene fra FARM-Farmakologisk, farmasøytisk forskning fordelt på fylker

Midlene fra FARM-Farmakologisk, farmasøytisk forskning fordelt på fagområde

Professor

NGFI-B er medlem i steroid/thyroid reseptor-familien (nukleær-reseptor-familien), og blir indusert i PC12-celler av nervevekstfaktor (NGF, derav navnet NGFI-B) og en rekke andre vekstfaktorer, bl.a. EGF. NGFI-B induserer apoptose ved å translokere til mit okondriene og fremme cytokrom c frisetting, uavhengig av proteinets funksjon som transkripsjonsfaktor. NGFI-B er nødvendig for apoptose i T-cellehybridomer. Vekstfaktorer regulerer celleproliferasjon, differensiering og celleoverlevelse ved å binde seg ti l reseptorer, som i sin tur formidler signaler til transkripsjonsfaktorer. Kinasene Erk1 og Erk2 integrerer slike signaler. Både NGF- og EGF-stimulering fører til fosforylering av NGFI-B-proteinet, men på forskjellige aminosyrer, noe som sannsynligvis er  viktig for proteinets funksjon. NGF-stimulering fører til serinfosforylering på aminosyrene 139 og 350. EGF-stimulering fører derimot til threoninfosforylering, som hittil ennå ikke er karakterisert. Vi har vist at Erk2 (som blir aktivert av EGF) fosfory lerer NGFI-B-proteinet <i>in vitro</i> på threonin 142. Målet for dette prosjektet er å studere de molekylære og cellulære konsekvensene av denne fosforyleringen. Prosjektet vil undersøke regulering av NGFI-Bs lokalisering til kjerne eller mitokondrier, t ranskripsjonell aktivitet og halveringstid, samt NGFI-Bs-potensielle rolle ved proliferasjon, differensiering og celledød ved apoptose i PC12-celler.

Farmakologisk karakterisering av vekstfaktoreffekter på transkripsjonsfaktor og apoptoseinitiator NGFI-B

I prosjektet har vi studert flere klasser av ikkelineære partielle differensialligninger, både lokale og ikke-lokale, samt både deterministiske og stokastiske. Disse ligningene kan brukes til å modellere mange ulike fenomener i naturen. Vi har vist at flere matematiske modeller for vannbølger som naturlig domineres av gravitasjonskraften, oppviser symmetri, lokalisering når de er små, men eksepsjonelle topper når de er store. Dette er gjort i en rekke modeller, og gjennom forskjellige metoder, ikke minst konstruksjon av slike løsninger til ikke-lineære og ikke-lokale ligninger som bestemmes av eksakte såkalte dispersjonsrelasjoner.   Videre har vi introdusert en ny klasse av modeller for tett trafikk på en flerfelts motorvei.  I tillegg har vi studert en klasse ikke-lineære transport-diffusjonsmodeller med veldig irregulære løsninger.  Her er både stokastiske og deterministiske ligninger studert. Vi har også studert utvikling av singulariteter for en klasse av ligninger.

WaNP is a  5-year FRIPRO Toppforsk project in mathematics at the Norwegian University of Science and Technology (NTNU). Its focus is basic research in nonlinear and nonlocal partial differential equations. The applicants are  H. Holden (principal investigator), M. Ehrnström, U. Skre Fjordholm, K. Grunert, E. R. Jakobsen, and P. Lindqvist. Funding is sought for 4 PhD students, 2 postdoctoral fellows, and operating expenses. Collaboration with world-leading international experts are included in the project.

Partial differential equations constitute the main tool to describe the physical nature. The main goal of  WaNP is  to analyze the interplay of singularities and nonlocal effects in a class of carefully selected wave equations. As singulairties appear, our tools to understand their behavior break down; and as nonlocal effects come into play, the study of essentially local singularities requires a global understanding of the problem. As part of our program we shall furthermore study both deterministic equations and equations with uncertainties.

The key question that we ask, is
 How do nonlocalities affect the appearance of singularities in wave equations?

Waves and Nonlinear Phenomena

The project is concerted effort between research groups at NTNU, UiO, and UiB working in nonlinear partial differential equations. The aim is to use recent progress in the theory of partial differential equations to gain a better understanding of existing  numerical methods as well as developing new methods.  The work will be focused on waves in fluids, nonlinear wave equations of variational form, and high-precision time integration schemes. Concerning waves in fluids, a new aspect is that the project wil l take into account compressibility effects. Another issue to be treated is the effect of a free surface, giving special consideration to the interplay of surface tension and viscosity. 
For the numerical treatment of certain nonlinear wave equations, the  variational structure of the problem will be exploited. In some cases the variational formulation can be used to formulate conservative numerical schemes. In other cases the problem contains a variational inequality that can be treated using special nume rical techniques, such as discontinuous Galerkin methods.
For some tasks it is imperative to have numerical schemes able to perform long term integration. In particular, this applies to partial differential equations of Hamiltonian form, where symplectic schemes can be used. Here the focus will be on further development of such methods, building on recent advances in the theory of multi-symplectic schemes.

The project will graduate 2 PhD candidates and will hire 2 postdoctoral fellows (one for one year a nd one for two years), and organize a workshop. The project will establish close colloboration with groups with similar aims at KTH, Uppsala and Chalmers in Sweden.

Waves in fluids and solids

The key idea of this proposal is to combine the modern theory of nonlinear partial differential equations with constructive numerical techniques to study rigorously important wave phenomena, many in the context of water waves. For several important nonlin ear partial differential equations of this type a numerical theory is lacking or incomplete. 
The project is built around two pillars: 1. Nonlinear convection-diffusion equations with discontinuous coeffi- cients. 2. Nonlinear wave-current interactions. T his pillar includes a variety of problems describing carefully selected water wave phenomena and extensions thereof.


Analysis and numerics for Nonlinear Waves (NonWave)

This programme aims to stimulate the theoretical study of spectral properties of partial differential operators which is a subject with many practical applications. Among them are problems appearing in solid state physics, superconductivity, problems cons erning stability of matter, telecommunication, etc. Stimulated by these and others applications this area of mathematical physics contains many outstanding difficult problems which mathematicians have been trying to solve during many decades. Recent progr ess in solving some of these problems is a major motivation for joining forces with different European research groups.

ESF - nettverksprogram: Spectral Theory and PDE (SPECT)

Prosjektet går ut på å studere algebro-geometriske løsninger av visse klasser av ikke-lineære differensialligninger som er fullstendig integrerbare. Spesielt ønskes å studere Camassa-Holm hierarkiet, et nytt system som er kalt Szego-Baxter systemet, samt Kadomtsev-Patviashivili-ligningen.

0 antall prosjekter

FRINATEK-Fri prosj.st. mat.,naturv.,tek

Waves and Nonlinear Phenomena

Tildelt: kr 12,7 mill.

Prosjektperiode: 2016-2022

Sted: Trøndelag - Trööndelage

FRINAT-Matematikk og naturvitenskap

Waves in fluids and solids

Tildelt: kr 7,3 mill.

Prosjektperiode: 2006-2010

Sted: Trøndelag - Trööndelage

BEMATA-Beregningsorientert matematikk i anv.

Analysis and numerics for Nonlinear Waves (NonWave)

Tildelt: kr 1,4 mill.

Prosjektperiode: 2004-2006

Sted: Trøndelag - Trööndelage

F-MAT-Naturvitenskap, matematikk

ESF - nettverksprogram: Spectral Theory and PDE (SPECT)

Tildelt: kr 0,17 mill.

Prosjektperiode: 2002-2006

Sted: Trøndelag - Trööndelage

F-MAT-Naturvitenskap, matematikk

Fullstendig integrerbare systemer

Tildelt: kr 0,20 mill.

Prosjektperiode: 2002-2005

Sted: Trøndelag - Trööndelage