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Dato fra ny til gammel

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Preventing opioid relapse and - overdose following discharge from detoxification or imprisonment - a multi-centre RCT

Avhengighet av heroin og andre opioider er en tung belastning for pasienten selv, for pårørende, og for samfunnet. Idag består anbefalt behandling av daglig dose med forskrevne opioider som metadon eller buprenorfin (subutex, suboxone), med førstevalg buprenorfin-nalokson (suboxone) som har laves...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2011-2016

Sted: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Life After STroke - The LAST study

LAST studien er en nasjonal randomisert kontrollert multisenter studie som har til hensikt å undersøke effekten av et langtidsoppfølgingsprogram etter hjerneslag. Personer som har vært innlagt ved slagenheten ved St. Olavs Hospital eller ved Bærum sykehus får tilbud om å delta i studien ved den p...

Tildelt: kr 5,7 mill.

Prosjektperiode: 2011-2016

Sted: Trøndelag - Trööndelage

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Caring for adult patients with acute exacerbations of asthma or COPD in general practice

Prosjektet har beskrevet pasienter i allmennpraksis med astma- og kolsforverringer, og hvordan forverringene blir behandlet. I en av studiene ble det samlet inn data fra 100 pasienter innlagt med astma- eller kolsforverring ved to norske sykehus. De som først hadde kontaktet fastlege hadde oftere...

Tildelt: kr 6,5 mill.

Prosjektperiode: 2010-2017

Sted: Troms - Romsa - Tromssa

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Early diagnosis of abdominal cancer in general practice - a cohort study

I prosjektets første fase ble det presentert av prosjektleder og stipendiat i radio og på UiTs informasjonssider. Prosjektleder har omtalt prosjektet på kurs i kreftdiagnostikk for allmennpraktiserende leger i Oslo i 2013, og på et møte i regi av Helsedirektoratet i 2011 som ledet opp mot den sen...

Tildelt: kr 5,1 mill.

Prosjektperiode: 2010-2016

Sted: Troms - Romsa - Tromssa

KLINISK-Klinisk forskning

Computernavigation vs conventional technique in knee arthroplasty. A randomised, clinical and radiostereometric trial

Background: Computer navigation in knee replacement surgery is increasingly being used around the world, but the documentation of its usefulness is lacking. To critically evaluate this new surgical method, we want to perform a prospective, randomised clin ical trial. Goal: We evaluate the need fo...

Tildelt: kr 5,6 mill.

Prosjektperiode: 2009-2012

Sted: Vestland

KLINISK-Klinisk forskning

Randomized controlled trial of postpartum pelvic floor muscle training in women with injured and non-injured pelvic floor muscles.

175 førstegangsfødende kvinner med fødeplass Ahus har blitt tilfeldig inndelt i to gruppe: en som har trent bekkenbunnsmusklene 1 gang i uken i gruppe hos fysioterapeut + hjemmetrening hver dag og en gruppe som ikke har fått noe ekstra tilbud ut over å læ re riktig sammentrekning av bekkenbunnsmu...

Tildelt: kr 6,1 mill.

Prosjektperiode: 2009-2014

Sted: Akershus

KLINISK-Klinisk forskning

Nutrition, growth and cogntive developement among very preterm infants

Basert på våre og andres tidligere studier er det mye som tyder på at svært premature barn får for liten tilførsel av mange viktige næringsstoffer rett etter fødselen. Til tross for at anbefalingene om næringsstofftilførsel har vært meget høye, er det ikke publisert studier som viser effekt av hø...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2009-2014

Sted: Oslo

KLINISK-Klinisk forskning

Diskusjonsmøte NAKKOF (Nasjonalt kompetansesenter for klinisk odontologisk forskning)

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Tildelt: kr 7 714

Prosjektperiode: 2008-2008

Sted: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Randomized trial for evaluation of mortality and morbidity of coronary revascularization with drug-eluting stent versus bare metal stent

NorStent er forskerinitiert, industriuavhengig, randomisert, norsk multisenterstudie som inkluderer 9013 pasienter med hjertesykdom. Hensikten er å sammenlikne langtidsresultat etter utblokking av hjertets kranspulsårer med to forskjellige metoder. Avleiringer i hjertets kranspulsårer fører ti...

Tildelt: kr 18,5 mill.

Prosjektperiode: 2008-2016

Sted: Troms - Romsa - Tromssa

KLINISK-Klinisk forskning

Thalidomide versus Velcade in melphalan refractory multiple myeloma

Standard treatment of patients under the age of 65 with multiple myeloma is high dose melphalan followed by infusion of autologous blood stem cells (ASCT). Standard treatment of patients over the age of 65 is low dose melphalan and prednisolon. Most patie nts respond to this treatment, but patien...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Trøndelag - Trööndelage

KLINISK-Klinisk forskning

Prevention of type 2 diabetes with vitamin D supplementation in subjects with reduced glucose tolerance detected in the Tromsø study

The prevalence of type 2 diabetes is increasing, which for most societies has considerable consequences not only regarding health but also economy. Type 2 diabetes develops through a prediabetic stage with impaired glucose tolerance. Intervention at this stage with change in lifestyle or with med...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2010

Sted: Troms - Romsa - Tromssa

KLINISK-Klinisk forskning

Understanding early events in Alzheimer disease (AD) pathogenesis: Integration of molecular, functional and structural imaging

This project will develop and employ integrated imaging techniques in the longitudinal study of patients with mild cognitive impairment (MCI). We aim to study mechanisms for Alzheimer disease induction, and to determine factors predictive for cognitive de cline and conversion to dementia. Fracti...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2008-2011

Sted: Akershus

KLINISK-Klinisk forskning

The treatment of periodontal diseases, A randomized, blinded, four-arm, placebo controlled clinical intervention trial

Periodontal disease is a family of bacterial infections characterized by the destruction of periodontal supporting tissues. The bacterial flora at the diseased sites is complex, counting more than 500 different species in the subgingival dental plaque. Th ree main hypotheses exist for the infecti...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

KLINISK-Klinisk forskning

The Prescription Peer Academic Detailing (Rx-PAD) study. A cluster-randomized educational intervention to improve GPs' prescription practice

The study will be employed as a cluster randomized study targeting 80 general practice (GP) continuous medical education (CME) groups (about 500 GPs) which will be randomized to recieve one out of two interventions - being controls for the other. Furtherm ore, an extended control group comprised ...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2008-2013

Sted: Oslo

KLINISK-Klinisk forskning

Rehabilitation after severe traumatic brain injury. A national multicentre study

In Norway, the annual rate of hospital admission caused by head trauma is around 200 per 100 000 inhabitants. About 15 % of the patients admitted to a neurosurgical department with traumatic brain injury, are in the severe group according to the Glasgow C oma Scale score. These patients demand in...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

KLINISK-Klinisk forskning

Is beta cell rest by insulin treatment beneficial in preserving beta cell function in latent autoimmune diabetes of the adult ( LADA)?

Latent Autoimmune Diabetes LADA) er en hyppig form av diabetes. Det er vist at mellom 5 og 10 % av alle pasienter med diabetes har LADA. Selv om denne formen av diabetes altså er hyppig er mye mindre kjent om hva som er beste behandling enn hva som er kjent for type2 diabetes (aldersdiabetes) ell...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2008-2015

Sted: Trøndelag - Trööndelage

KLINISK-Klinisk forskning

Workshop med vekt på metodekompetanse innen uspesifikke rygg- og muskel/skjelettplager

Rygg, og andre muskel- og skjelettlidelser er de hyppigste årsakene til langvarig sykemelding og uføretrygd i Norge. Ryggplager forekommer i høy grad sammen med andre plager, f.eks andre muskelplager, tretthets- og utmattelsestilstander, plager fra mage- tarmsytemet og lettere tilstander med angs...

Tildelt: kr 0,10 mill.

Prosjektperiode: 2007-2007

Sted: Vestland

KLINISK-Klinisk forskning

International workshop to determine standard questionnaire when investigating population use of CAM. An international survey.

Background: There are no international consensus-based guidelines for how to monitor use of CAM. Wide discrepancies exist between culturally similar countries and regions. Objective: The aim of the present workshop is to discuss challenges in registering population CAM use, and develop a set of...

Tildelt: kr 0,10 mill.

Prosjektperiode: 2007-2007

Sted: Troms - Romsa - Tromssa

KLINISK-Klinisk forskning

Functioning disturbance in chronic back pain: Altered muscle activation pattern, muscle metabolism and pain-cognitions.

There is evidence that individuals with chronic non-specific back pain (CNSBP) show altered muscle activation patterns. It is unknown why these alterations in activation pattern occur, which consequences this may have for muscle metabolism and how they ar e linked to pain experience and developme...

Tildelt: kr 2,0 mill.

Prosjektperiode: 2007-2015

Sted: Vestfold

KLINISK-Klinisk forskning

Patient education in patients with chronic obstructive pulmonary disease (COPD) and rheumatic disease: effect, experiences and costs

This is (hopefully) an improved version of an earlier application to NFR that was reviewed as both "a high quality research program" and "poorly written and non-competitive". The comments from the reviewers have been used to revise the project. Patient e ducation has become a task that is dictat...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

KLINISK-Klinisk forskning

Spontaneous firing activity in motoneurones of cervical paraspinal musculature in healthy subjects and in patients with neck pain

I prosjektet "Spontan elektrisk aktivitet i nerveceller til nakkemuskler hos friske frivillige og nakkesmertepasienter" forsøker vi å forstå mer av årsakene til nakkesmerter, ved å studere hvordan nerveceller i ryggmargen styrer nakkemusklene i ro og ved bevegelser. Vi ønsker å finne ut om disse...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2007-2014

Sted: Oslo

KLINISK-Klinisk forskning

Genetic susceptibility and development of chronic sciatic pain - possible implications for future treatment

Previous findings suggest that development of chronic sciatic pain results from multiple functional changes in the peripheral and central nervous system. As described in this grant proposal, several recently described human genetic variants may affect suc h processes. Hence, individual genetic su...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

KLINISK-Klinisk forskning

Does fusion lead to increased adjacent level disc degeneration in patients with chronic low back pain. An international collaborate project.

There is controversy as to whether fusion of one or more motion segments of the spine results in accelerated degeneration of the adjacent segment over time. Some argue that adjacent segment is exposed to increased mechanical stress, which accelerates disc degeneration, whilst others maintain tha...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

KLINISK-Klinisk forskning

Stimulating self-management in patients with fibromyalgia syndrome through web-based situational feedback

Self-management of chronic pain is increasingly seen as an important tool in providing adequate care to patients with Fibromyalgia Syndrome (FMS) and other types of Chronic Non-malignant Pain. Enhancing the patient's self-management of his condition is th ought to be effective in reducing pain an...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

KLINISK-Klinisk forskning

Effect of Intravenous immunoglobulin (IVIG) on left ventricular remodeling after acute myocardial infarction

The current project attempts to study inflammatory and immunologic mechanisms in heart failure (HF). We hypothesize that intravenous immunoglobulin, given in the acute phase following myocardial infarction in patients at risk for developing heart failure HF, will improve cardiac performance, and ...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

KLINISK-Klinisk forskning

A multicentre RCT of brief intervention(BI) vs BI+CBT vs nutritional supplementation for pateints with long-lasting muscle and back pain

National and international research have shown "Brief Intervention" (BI: examination, advice, encouragement to resume normal activities) to be a cost effective clinical treatment for low back pain. Research from participants in the Norwegian Back Pain Res earch Network has shown that BI followed ...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2006-2011

Sted: Vestland

KLINISK-Klinisk forskning

Catheter directed thrombolysis in the treatment of acute deep vein thrombosis - a randomized clinical trial

Rationale: Deep vein thrombosis (DVT) is a severe disease which may cause severe disability and which is sometimes fatal. Conventional treatment with low molecular weight heparin (LMWH) and oral antiocoagulants is associated with some degree of long-term sequalae, i.e., post-thrombotic syndrome (...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2012

Sted: Oslo

KLINISK-Klinisk forskning

Autoimmune polyendokrine syndrome type I- model disease for autoimmunity

Autoimmune polyendocrine syndrome type I (APS-I) (OMIM 240300), is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene. The disorder typically begins in early childhood and the patients gradually develop autoimm une destruction of different endocrine an...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

KLINISK-Klinisk forskning

Stimulated differentiation of native human acute myeloid leukemia (AML) blasts as a potential cancer-cell specific therapeutic target

Acute myeloid leukemia (AML) is an aggressive disorder characterized by accumulation in the bone marrow of large numbers of abnormal blood cells that fail to develop into normal functional blood cells. This is a life-threatening condition if not treated. Patients under the age of 60 are given int...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2010

Sted: Vestland

KLINISK-Klinisk forskning

MOLECULAR MR IMAGING OF BREAST CANCER Treatment monitoring and prognostic evaluation

Successful cancer treatment and recovery depends upon early diagnosis, but also important is the decision on which type of treatment each cancer patient should receive. Through a combination of new contrast agents and improved technology, MR is making adv ances in identifying the functional and m...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2006-2010

Sted: Trøndelag - Trööndelage

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