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Dato fra ny til gammel

PES-HORISONT-EU-PES Horisont Europa

Clinical validation of a new diagnostic test for Drug SEnsitivity Evaluation in ColoRectal Cancer (DSEE-CRC)

...cancer treatment relies on poorly personalized drug...cancer are treated with chemotherapy, often to no avail, and drug and treatment costs continue...These factors result in low quality of life for patients and high costs for healthcare...

Tildelt: kr 99 999

Prosjektperiode: 2022-2022

Sted: Oslo

FRIPRO-Fri prosjektstøtte

Phenotypic Drug Screening to support personalized medicine for colorectal cancer.

...cancer treatment poses a challenge for physicians...approaches in clinical research investigate how to adopt patient material to grow 3D spheroids and...these approaches provide rapid functional information to guide physicians towards choosing a...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2021-2025

Sted: Trøndelag - Trööndelage

EUROSTARS-EUROSTARS

E!2584: Clinical validation of a new diagnostic test for Drug SEnsitivity Evaluation in ColoRectal Cancer (DSEE-CRC)

...is a new in vitro diagnostic (IVD) platform for selecting the most effective drug...cancer patients. The IVD is based on drug screening of the patient’s own living cancer cells...a unique analysis of the cells’ response to a range of clinically relevant drugs and drug...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2023-2026

Sted: Oslo

FRIPRO-Fri prosjektstøtte

Drug repurposing: new options for prevention and treatment of colorectal and breast cancer

...development of new targeted therapies for cancer has proven difficult, and prices of new...Repurposing the large arsenal of approved non-cancer drugs is an attractive strategy to offer...treatment options. We will seek evidence to support new use of nonsteroidal anti-inflammatory...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2020-2024

Sted: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Computational modelling and functional validation platform for personalised colorectal cancer clinical therapy decision support (ONCOLOGICS)

...Cancer is the second leading cause of death in the...than 150.000 persons within EU-28 die of colorectal cancer (CRC) every year (more than 10% of...and immunotherapies, survival has now increased to roughly three years. Although new targeted...

Tildelt: kr 4,1 mill.

Prosjektperiode: 2021-2024

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Bioinformatics platform for the pharmacogenomic analysis of sequence variation in complex diseases

...studies of complex disease and drug response have utilized a one gene one drug...technology , the future trend of personalized medicine lies in understanding and...their sequence variation and the affected drug response. Novel and innovative bioinformatics...

Tildelt: kr 3,5 mill.

Prosjektperiode: 2008-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Effectiveness of colorectal cancer screening on colorectal cancer incidence and mortality

...Colorectal cancer (CRC) is a leading cause of cancer...the world with the highest incidence of CRC. Screening for fecal occult blood (FOBT) has been...randomized controlled tri als (RCT). Other screening modalities used for CRC screening are...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2011-2014

Sted: Telemark

EUROSTARS-EUROSTARS

E!10126 Precision Cancer Medicine Pipeline and Services

...nearly 3.5 million people are newly diagnosed cancer cases, and more than 1.75 million deaths...years, precision oncology has been driven forward by several key factors, like (1) the...technology; (2) the improved capability of bioinformatics tools; (3) increased patient awareness;...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2016-2018

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

ValidAI Clinical VALIDation and implementation of the AI-based digital biomarker Histotype Px to personalize treatment in colorectal cancer

...is a large need and potential for better and more cost-effective care for cancer...(7%), however most patients (+50%) suffer from toxic overtreatment. Recent breakthroughs in...digital biomarkers to extract and utilize information from tumour tissue not visible to the...

Tildelt: kr 16,0 mill.

Prosjektperiode: 2024-2027

Sted: Oslo

FRIPRO-Fri prosjektstøtte

High-dimensional analysis of AXL-mediated immunotherapy resistance: Clinical translation for personalized medicine

...Cancer is the leading cause of death in Norway and...treatments such as immunotherapy do not afford lasting clinical benefit. Cancer cells...increased mortality. Our research shows that cancer cells use the AXL receptor to resist therapy...

Tildelt: kr 12,0 mill.

Prosjektperiode: 2020-2026

Sted: Vestland

EUROSTARS-EUROSTARS

E! 7820 A novel platform for "Next Generation Kinome Profiling"

...aim of this project is to develop a novel protein kinase assay that...developed using this technology can be used to determine the most optimal combination of...partner (E rasmus Medical Center) will join forces to develop a "Next Generation Kinome...

Tildelt: kr 3,7 mill.

Prosjektperiode: 2013-2016

Sted: Oslo

PES2020-Prosj.etabl.støtte H2020

Feasibility study on validation of DNA cancer biomarkers by IR spectroscopy to guide personalized medical care

...establishment of project proposal is directed towards H2020, to SME's Instrument - Phase 1 2014....business plan, as well a feasibility study to verify technological, practical and economic...of the company work package proposal to analyse bottlenecks and to identify how a Phase...

Tildelt: kr 39 999

Prosjektperiode: 2014-2015

Sted: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

Effect of screening with flexible sigmoidoscopy on colorectal cancer incidence and mortality

...Colorectal cancer (CRC) is a leading cause of cancer...with the highest incidence of CRC. The reason for this is unknown. The Norwegian Colorectal...(NORCCAP) is a randomised controlled trial performed in 1999-2001. 100,210 people aged 50-64...

Tildelt: kr 0,33 mill.

Prosjektperiode: 2013-2014

Sted: Agder

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The Nordic-European Initiative on Colorectal Cancer (NordICC)

...Colorectal cancer (CRC) is a major burden in western...CRC precursor lesions and may thus be effective for CRC prevention. According to European Union...of the target disease is a prerequisite before advocating population-wide cancer screening....

Tildelt: kr 13,8 mill.

Prosjektperiode: 2010-2015

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

Clinical feasibility of in vitro diagnostic drug testing for pancreatic cancer

...cancer has the lowest survival rate among major...and yearly accounts for nearly 500,000 (5% of total) cancer deaths worldwide. Available...rates below 25% creating an urgent need for new therapies and methods that can select...

Tildelt: kr 16,0 mill.

Prosjektperiode: 2024-2028

Sted: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Inno-Indigo: Nanoplatform-based drug delivery system: combinational therapy against breast and colorectal cancer

...aims at using the lipid nanocapsule (LNC) drug delivery system we have recently developed for...on the surface and can load a broad range of drug molecules. Our approach is to develop a novel...issues: (i) A significant portion of the drug molecules end up in normal organs, rather than...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2016-2019

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

GLIXOV: GLIX5 for Ovarian Cancer

...Cancer is the second-leading cause of death...intractable diseases humanity has ever faced. For most cancers, only a small fraction of...from current therapies, which means that most cancer-associated healthcare costs are “wasted” on...

Tildelt: kr 16,0 mill.

Prosjektperiode: 2024-2025

Sted: Oslo

EUROSTARS-EUROSTARS

E!114899: Automated high-throughput oncology drug screening in zebrafish using robotics and AI

...project goal is to develop robots for oncology drug screening in...new cases and 9.6 million deaths in 2018. Drug candidates are assessed in living organisms...process. Consequently, only 9% of oncology drugs entering phase 1 clinical trials, complete...

Tildelt: kr 5,7 mill.

Prosjektperiode: 2021-2024

Sted: Oslo

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Coping with the Burden of Colorectal Cancer Screening - the Surveillance after Adenoma Removal (SAR) trial

...Colorectal cancer is a major health burden with more...than 800 cancer deaths annually in Norway. Screening for colorectal cancer is widespread in the...incidence and mortality. As a result of colorectal cancer screening, more individuals undergo...

Tildelt: kr 9,0 mill.

Prosjektperiode: 2014-2020

Sted: Oslo

NANO2021-Nanoteknologi og nye materiale

Biodegradable Nanoparticles in Cancer Diagnosis and Therapy

...goal of this project is to build the necessary expertise in...and thereby engineer safe and efficient NPs for use in medical imaging and personalized...carriers of both hydrophobic and hydrophilic drugs, thus enabling delivery of unique drug...

Tildelt: kr 30,5 mill.

Prosjektperiode: 2013-2019

Sted: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

LegRegPCM - Legal Regulation of Information Processing relating to Personalized Cancer Medicine (PCM)

...and prevention, in particular in the field of cancer medicine. Instead of a one-size-fits-all...disease groups. This differential approach to specific subsets of tumor mutations is...in determini ng cancer progression and response to therapies. This research strategy is often...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2015-2020

Sted: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

DL: Pipeline for individually tailoring new treatments in hematological cancers (PINpOINT)

...Hematological cancers are well suited to leverage the...tailor drug therapy. Here, we will implement cancer drug sensitivity screening (CDSS) using a...Guided by predictive statistical models we aim to identify tailored treatments for individual...

Tildelt: kr 20,4 mill.

Prosjektperiode: 2019-2023

Sted: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

EPoS European Polyp Surveillance trial

...protocol describes the epos (ancient Greek (?p??) for...unsolved challenges in the prevention of colorectal cancer (one of our major cancer killers);...This project is timely because large scale colorectal cancer screening programmes are currently...

Tildelt: kr 10,2 mill.

Prosjektperiode: 2014-2019

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

MPECS to detect high risk colorectal adenomas

...Colorectal cancer (CRSC) is one of the leading cancers...preceded by a pre-invasive phase, called colorectal adenoma (CRA). About 2-5% of all CRAs pro...of polyps, polyp size, dysplasia grade and histologic type) are inaccurate. The number of...

Tildelt: kr 1,7 mill.

Prosjektperiode: 2005-2008

Sted: Rogaland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

COLOSS - COLOn Screeening and Surveillance: Comparative Effectiveness of Colorectal Cancer Screening and Surveillance

...a remarkable development and is now on the edge to become a world-leading research environment in...Funding from this application will enable to reach this goal within the next 5 years. Formal...involvement); the NORCCAP (NORwegian Colorectal Cancer Prevention) With 100,000 patients,...

Tildelt: kr 10,0 mill.

Prosjektperiode: 2016-2022

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

GenomeMiner: a software tool enabling personalized cancer medicine

...dawn of personalized medicine promises to revolutionize the...only be classified and treated based on anatomical and pathological findings, but will also...software tool named GenomeMiner, to enable personalized cancer medicine. The tool will facilitate...

Tildelt: kr 9,0 mill.

Prosjektperiode: 2012-2015

Sted: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

KSP: CellFit - T cells fit to fight cancer

...outcomes reported for solid tumour adoptive cell therapy have been...require development. Standard, non-optimal, formulae are currently used in manufacture and a...cell response. Large-scale testing is required to identify these factors. By merging automated...

Tildelt: kr 22,5 mill.

Prosjektperiode: 2021-2025

Sted: Oslo

FKB-Forskningssentre for klinisk behandling

Multimodal Approach Targeting treatment Refractory cancers usIng neXt generation technologies and trials

...of on-going large national precision cancer medicine initiatives, the national tumor...care and the unique infrastructure for clinical trials to facilitate development and...methods in molecular profiling (-omics), drug sensitivity screening, immune system...

Tildelt: kr 128,0 mill.

Prosjektperiode: 2022-2030

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Axl regulates stem cell traits in normal and malignant epithelial cells: Basic biology and clinical translation

...of molecularly targeted therapeutics, cancer remains a leading cause of death. A...how a tumor evolves from it's clonal origin to achieve this phenotypic diversity, and how this...cells activate gene programs in response to drug treatment and host immune challenge that...

Tildelt: kr 8,8 mill.

Prosjektperiode: 2015-2018

Sted: Vestland

IS-AUR-Samarb.progr. Norge Frankrike

Nanocarriers for new anti-cancer drugs

...of drug resistance and side-effects necessitate the...drugs, whether by chemical synthesis or by screening of natural products. This project aims to...to ensure maximum therapeutic effect of anti-cancer drugs. We will benefit from two research...

Tildelt: kr 40 000

Prosjektperiode: 2014-2014

Sted: Vestland

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