0 antall prosjekter

Dato fra ny til gammel

FUGE-Funksjonell genomforskn.i Norg

Bacterial flagellin: a novel adjuvant for vaccine strategies

The focus will be on development of strongly protective vaccines aimed primarily to fish, but the knowledge generated will be highly relevant within vaccine development to mammalian species - as fish possess very similar immune defence mechanisms compared to mammalian species. This will be achie...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Troms - Romsa - Tromssa

SFF-Sentre for fremragende forskn

Centre for Immune Regulation, CIR

Senter for immunregulering har hatt som mål å identifisere og karakterisere årsaker til feilregulering av immunsystemet. En slik feilregulering kan gi autoimmunitet og allergi. Forskerne i senteret har studert hva som går galt i samspillet mellom immuncellene både på cellulært og molekylært nivå...

Tildelt: kr 109,3 mill.

Prosjektperiode: 2007-2018

Sted: Oslo

NANOMAT-Nanoteknologi og nye materialer

Pure and ultra-fine grained Titanium for biomedical applications

A high strength to weight ratio, corrosion resistance and biocompatibility are properties which have made Ti-alloys the preferred metallic material for medical implants/prostheses. Depending on the type of implant, these alloys range from highly ductile a nd commercially pure variants, where a hi...

Tildelt: kr 5,6 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

zEPISTEM: DEFINING STEMNESS BY ASSESSING THE EPIGENETIC BASIS OF PLURIPOTENCY IN EMBRYONIC STEM CELLS OF ZEBRAFISH

Chromatin organization around active or repressed genes starts to be elucidated, but the packaging of a gene into a chromatin structure compatible with potential for transcription, such as in a pluripotent cell, is largely unknown. The zEPISTEM research p rogram aims at identifying novel gene mar...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Targeting of a PKA-AKAP18d-phospholamban signalling complex in the heart as therapy for chronic heart failure

The adrenalin-beta-adrenergic receptor-cAMP-protein kinase A signalling pathway regulates heart rate and contractility. Although changes in cardiac myocyte contractility either cause or are associated with cardiovascular disease, surprisingly few drugs ar e available that modulate the cardiac myo...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Single Cell Profiling of Phospho-Protein Networks in Health and Disease - From Signalling Profiles to Future Biomarkers

This proposal describes plans for a research project to be undertaken by a strong concortium of PI's (Gjertsen, Lorens, UoB; Torgersen, Aandahl, Tasken, UoO) and aiming to characterize key events in intracellular signalling networks that regulate cellular properties and behaviour in health and d...

Tildelt: kr 10,0 mill.

Prosjektperiode: 2007-2012

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Secretomes of lactobacilli and enterococci and their impact on bacterial adaptation and human health

Lactic acid bacteria belonging to the genera Lactobacillus and Enterococcus are normal inhabitants of fermented food products and of the human gastrointestinal tract. The impact of these bacteria on human health varies from beneficial to harmful. We will conduct genome-wide studies of surface-loc...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2014

Sted: Akershus

BIA-Brukerstyrt innovasjonsarena

A Combinatorial Mutagenesis Approach to Improve Microbial Expression Systems

Proteins have a broad range of medical and industrial applications, and today the majority of all commercial proteins are produced recombinantly, most often by using bacteria and yeast as production hosts. The scientific literature on microbial recombinan t protein production is comprehensive, bu...

Tildelt: kr 13,0 mill.

Prosjektperiode: 2007-2012

Sted: Trøndelag - Trööndelage

NANOMAT-Nanoteknologi og nye materialer

Nanoscale Control of Mineral Deposition within Polysaccharide Gel Networks

Controlled deposition of minerals within polysaccharide gels offers a new route to improve properties of gel based materials as well as to make new composites. By deposition of the mineral component within soft and compliant gel matrix, we will create new composite materials with controlled mech...

Tildelt: kr 4,6 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Structure based rules for protein kinase inhibitor selectivity

Protein kinase inhibitors are now emerging as a major class of new targeted drugs. Many diseases, especially cancers, are associated with disregulation of signalling pathways, and modulation of protein kinase activity is now a clearly validated approach f or therapy. Because there are over 500 pr...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2013

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Mechanisms mediating transfer and persistence of antibiotic resistance, and dissemination of virulence genes in streptococci and enterococci

The present project will study mechanisms for genome variation and maintenance in two closely related groups of bacteria Streptocococcus pneumonia and Enterococcus (E. faecalis and E. faecium). While S. pneumonia is considered as a sole pathogen, though 4 0% of humans carry this species, the two ...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2013

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

IMAGING GENETICS OF SCHIZOPHRENIA. A WHOLE GENOME - BRAIN MRI STUDY

Schizophrenia is a severe psychiatric disorder characterized by psychotic symptoms, cognitive dysfunction and poor outcome, and is a major public health problem with a high cost for society. Brain imaging studies have shown structural abnormalities and dy sfunction in specific brain regions. The ...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Exploring the T cell receptor genome - the next generation cancer immunotherapeutics

We will generate recombinant T cell receptors (TCRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cells that recognize telomerase have been isolated ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

New strategies for efficient development of microbial bioprocesses

This project is a collaboration between SINTEF Materials and Chemistry, Department of Biotechnology, the Department of Biotechnology at NTNU and Alpharma AS. The project builds on the existing competence among the project partners in developing industrial bioprocesses and will make use of state ...

Tildelt: kr 6,4 mill.

Prosjektperiode: 2007-2012

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Functional genomics in ascidians through insertional mutagenesis and homologous recombination

Ascidians, or sea squirts, are marine invertebrate chordates. Their critical evolutionary position as basal chordates and the simplicity of their embryogenesis have attracted great attention from developmental and evolutionary biologists. Recently, ascid ians have become one of the most promisin...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

From comparative genomics to systems biology - unravelling novel principle virulence mechanisms in pathogenic spore-forming bacteria

In the past decade, our research group has been involved in the characterization of virulence mechanisms in Bacillus cereus group bacteria. Here we propose to study two processes connected to development of resistance to antimicrobial compounds - the func tion and cellular response of multidrug r...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FRIBIO-Biologi og biomedisin

Oil induced autoimmune arthritis

We here present evidence that a novel class of genes encoding regulatory leukocytereceptors may be of clinical importance in autoimmune diseases elicited by environmental exposure to immunoadjuvants, in particular mineral oils. The evidence is based on th e structural identification of the rat Oi...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

The roles of microRNAs and transcription factors in gene regulation and tissue specific expression

MicroRNAs (miRNAs) were identified as a large group of regulatory genes in 2001, and increasing research has revealed these genes to be important in development, including differentiation, proliferation, and apoptosis. Many miRNAs seem to have tissue-spec ific expression patterns, which suggest t...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Interactomics of DNA Repair

The single most important factor for the correct functioning of genomes is that their coding information is maintained intact and transferred unperturbed to future generations. DNA repair is highly coordinated- and integrated with other fundamental cellul ar processes such as transcription, repli...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

SYSTEMS BIOLOGY IN THE MARINE TUNICATE OIKOPLEURA DIOICA

Gene regulatory modules are central to the coordination of an organism's developmental program and responses to its environment and understanding of them is a key objective of modern molecular biology and medicine. The sophisticated cis-regulation of gene expression in higher metazoans often ext...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Alkaline shock and excitotoxicity in epilepsy: RNAi in vivo - tools for investigation and prospects for therapy

Epilepsy is one of the most common forms of brain disorders, affecting about 1 % of the population. Alkaline shock, the rise of intracellular pH, is one of the few basic explanations of seizures that are now gaining a clear mechanistic description. Very r ecently a direct link between seizures, C...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

SFF-Sentre for fremragende forskn

Centre for Cancer Biomedicine, CCB

Grunntanken bak dannelsen av CCB var å forene basalbiologisk forskning på mekanismer i kreftutvikling med pasientnær kreftforskning som tar sikte på å identifisere nye kjennetegn på kreft som kan brukes i diagnose, prognose og terapi. Dette har vist seg som en vellykket forskningsstrategi, og CCB...

Tildelt: kr 120,6 mill.

Prosjektperiode: 2007-2018

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Contextual Regulation of Cell Proliferation & Differentiation in Angiogenesis: Integrated Functional Genomic Discovery &Validation Approach

Angiogenesis, the formation of new blood vessels from extant vasculature, is a fundamental homeostatic process and a key factor in the progression of many pathological conditions. Angiogenesis is defined by the growth and differentiation of endothelial ce lls. We conceptualize angiogenesis as a c...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

O-LINKED PROTEIN GLYCOSYLATION IN BACTERIA

Protein glycosylation is a pivotal element of biological systems not only because it is one of the major post-translational modifications but also because it has significant effects on protein properties and functions. We have recently discovered, and par tially characterized, the first general O...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Regulation of Nuclear Receptor Function by Posttranslational Modifications

Nuclear receptors (NRs), together with coregulatory proteins, coordinate the transcription of gene networks in response to ligand binding and cellular signaling in such diverse biological programs as reproduction, development, nutritent uptake, metabolism and excretion. PMTs have proven to be es...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Understanding the System of Neurotransporters

The proposed project is a system-biology approach to transport across brain plasma membranes focusing on neurotransmitter inactivation and water transport. The primary aim is to prepare the ground for a large scale approach to understand what all the hund reds of transporter and ion channels do t...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

NANOMAT-Nanoteknologi og nye materialer

Nanostructured biomaterials for improved vascularization in tissue engineering

Understanding the interactions between cells and materials is of fundamental importance for tissue engineering and regenerative medicine. An ideal scaffold should mimic the natural tissue microenvironment, directing cells to organize into a functional mul ticellular architecture by presenting the...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

NANOMAT-Nanoteknologi og nye materialer

Uptake and toxicity of quantum dots in cancer cells

Most of the work on quantum dots has so far been focused on their production and fluorescence imaging. The possibility to use quantum dots as photosensitizers remains unexplored: Can these nanoparticles generate reactive oxygen species in biological envir onments? Such a potential of quantum dots...

Tildelt: kr 5,6 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

BIA-Brukerstyrt innovasjonsarena

Drug targeting of protein-protein and ligand-protein interactions

Chemical biology (CB) involves use of small molecules to perturb and study biological function. Small molecular compounds (SMC) with molecular weight below 500 Da have proven extremely important to explore function at the molecular, cellular, and in vivo level and for treating diseases. Most medi...

Tildelt: kr 7,2 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Tumor Targeting Antibodies in Colorectal Cancer

Objective: The main purpose is to identify and characterize novel antibodies recognizing specific antigens on colorectal cancer cells. Interesting candidates will be thoroughly examined for their specificity and their ability to be used as diagnostic and/ or prognostic markers. Their potential as...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

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