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Algebraic Theory of Information Quantities

Information theory is a discipline at the intersection of statistics, engineering and computer science. As the study of information quantities, such as compression or communication capacities, information content or measures of statistical dependency, it is one of the theoretical underpinnings of data science.

Computational problems in information theory are highly non-linear. The goal of this project is to transfer state-of-the-art methods of computational non-linear algebra to information theory, to study the inherent algebraic complexity of information-theoretical problems and to provide tools for solving them in practice. The algebraic point of view has proven to be fruitful in seemingly unrelated areas, as witnessed by a surge of recent work in algebraic statistics, in particular on likelihood geometry. However, maximizing the likelihood function is the same as minimizing relative entropy — a specific information quantity. Hence, this project also aims at generalizing the techniques developed in likelihood geometry.

One focus is on the practical computation of information quantities using numerical and differential algebraic geometry. Such quantities are defined via non-linear optimization problems and we aim to pinpoint the algebraic complexity of these problems in instances of general interest, such as common information measures. The final objective is finding fundamental laws and limits of data science imposed by non-linear inequalities constraining the entropic region. These inequalities provide, by duality, universal bounds for many of the optimization problems studied in information theory.

WHeelchair Activity Monitoring project (WHAM)

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

EOSC Beyond: advancing innovation and collaboration for research

EOSC Beyond overall objective is to advance Open Science and innovation in research in the context of the European Open Science Cloud (EOSC) by providing new EOSC Core capabilities allowing scientific applications to find, compose and access multiple Open Science resources and offer them as integrated capabilities to researchers. To do so, EOSC Beyond supports a new concept of EOSC: a federated and integrated network of Nodes operated at different levels, national, regional, international and thematic, to serve the specific scientific missions of their stakeholders. Further specific objectives of the project are to accelerate ‘time to product’ of new scientific applications with software adapters, enable Open Science with machine composability and dynamic deployment of shared resources, support innovation in EOSC with a testing and integration environment, and align the EOSC Core architecture and specifications to integrate with European dataspaces. The project extends the state of the art of the EOSC Core and adopts a co-design methodology, including requirements elicitation, software development and validation in collaboration with different use cases from EOSC national and regional initiatives (e-Infra CZ, Czechia, NFDI, Germany, and NI4OS, South East Europe region), thematic research infrastructures from Social Sciences and Humanities (CESSDA), Life Sciences (CNB-CSIC and Instruct-ERIC), Environmental Science (ENES and LifeWatch), and Health and Food (METROFood-RI). EOSC Beyond builds on the capacities of prospective EOSC Nodes and partners with multi-annual experience in developing solutions for large-scale federated digital infrastructures and aligns with the technical architecture and requirements of data spaces from different business sectors. Ultimately, EOSC Beyond supports Open Science in modern, data-intensive, and multidisciplinary research, facilitating resource discovery, access, and reuse across scientific communities, organisations, and countries.


Harmonization of Advanced Materials Ecosystems serving strategic Innovation Markets to pave the way to a Digital Materials & Product Passport

The overarching objective of DigiPass is to enhance the digital maturity of the European communities that develop materials and intermediate products. The project will develop recommendations and clear routes toward digitalized circular business models. The overarching key result of DigiPass is to create a sustainable platform which includes support for Digital Materials & Product Passport and for collaborative innovation-by-design processes in a circular economy served by advanced materials. A business model for operating such a platform completes the overarching objective.
DigiPass is harmonizing and synergizing collected materials data sources and digital infrastructures. This will enable interoperability of data exchange, and standardization of advanced materials knowledge representation at all maturity levels. Accelerating the design, development, and production of advanced, safe, and sustainable chemicals and materials, as they are necessary for innovative products, calls for a collaborative approach involving different stakeholders to support durability, repair and overhaul, reuse, and recyclability of products. DigiPass project impacts all materials development communities over the whole circular value chain. 


Enhanced X(cross)-disciplinary Community-driven Imaging Technologies for Earth and Environmental material research

The EXCITE² Network is revolutionizing Earth and environmental material science research by consolidating a critical mass of 18 research facilities in 12 European and associated partner countries into a unified infrastructure and providing transnational access to advanced imaging technologies. This enables scientists to decipher complex processes within Earth materials at scales from nanometres to hundreds of centimetres, gaining unparalleled insight into the chemical and physical processes that govern, among others, environmental toxicity and its impact on human health, critical metal extraction for renewable energies, and the utilisation of Earth materials as long-term storage for climate-altering gases. The consortium fosters knowledge-sharing and talent attraction, bolstering the problem-solving capacity of the European Research Area. Moreover, EXCITE² is driving interdisciplinary collaboration and cross-fertilisation across academic institutions, scientific disciplines, and industry, propelling Europe towards a sustainable future. The initiative offers dedicated training programmes to a new generation of researchers within the European open science landscape, paired with access to world-class imaging facilities and expertise for problem-solving research and innovation. EXCITE² is introducing innovative service developments, such as artificial intelligence and leading-edge imaging experiments, to increase the user's problem-solving capacity. In addition, the consortium is implementing customised project valorisation strategies to maximize the impact of research outcomes in academia, society, and the economy. Citizen science projects allow the public to participate directly within the EXCITE² Network, contributing to solving EU challenges. As such, EXCITE² is paving the way towards a sustainable future, driving scientific excellence, and creating positive societal impact.

Engineering carbon quantum dots for zinc ion hybrid capacitors

Zinc ion hybrid capacitors (ZIHCs) integrate two energy storage mechanisms of battery-type electrode and capacitive electrode, bearing the advantages in energy density, power density, and safety. Until now, the cycle retention rate of ZIHC's capacity reported is still not more than 80%, restricting its development and commercial application severely. Focusing on the issue, the project aims at overcoming the limitation of traditional electrode materials and re-defining the designing concept to construct Carbon Quantum Dots (C-QDs) for ZIHCs. Advanced methods will be used to harvest carbon quantum dots from coal tar pitch (a sort of industrial solid castoff). The bulk sp2-carbon network, innumerable edge sites, profuse surface functional groups, and regular size ensures that as-synthesis C-QDs have high electrical conductivity, sufficient ion transport channels and rich adsorption sites. Moreover, the new concept of dynamic evolution is introduced for insight into the structure and interface failure of ZIHC's electrode. The interface-reconstruction mechanism and the attenuation model of capacity will be established for the first time. Further, the methods to strengthen structures of C-QD electrode will be developed based on a trade-off strategy. The ultimate goal is to improve the energy storage efficiency of ZIHCs by 20% and to increase their cycle performance more than 95% unprecedentedly. This research will develop long-running high performance ZIHCs, for contributing European energy storage industry. The ER will achieve abundant research experience and scientific skills from the project and the capability to launch her own research group in future.

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Aqua Research Infrastructure Services for the health and protection of our unique, oceans, seas and freshwater ecosystems

AQUARIUS will provide a highly comprehensive suite of integrated research infrastructures appropriate to addressing significant challenges for the long-term sustainability of our unique oceans, seas and freshwater ecosystems. For the first time, diverse research infrastructures will be combined to facilitate the work of researchers and key stakeholders focused on challenges and opportunities for both marine and freshwater systems. An impressive range of 57 research infrastructure services will be made available to include research vessels, mobile marine observation platforms, aircraft,  drones, satellite, sensors, fixed freshwater and marine observatories and test sites, experimental facilities, and sophisticated data infrastructures. AQUARIUS will support the development phase of the EU Mission to Restore our Ocean and waters by 2030, the Sustainable Blue Economy Partnership, the European Green Deal, and international climate initiatives. It will also be an essential component in achieving the European Digital Twin of the Ocean and the UN Decade for Ocean Sciences. The needs of researchers will be met through a robust and transparent system of transnational access funding Calls, facilitated by centralised user-friendly access portal. The Call programme will be informed through stakeholder engagement and brokerage events. Projects to be selected for Access must convincingly integrate multiple infrastructures and contribute to the core policy objectives of Mission Ocean, that is, to protect and restore marine and freshwater ecosystems and biodiversity; to prevent and eliminate pollution of our oceans, seas and waters; and to ensure a sustainable, carbon-neutral and circular blue economy. A thematic and geographic focus will be the hallmark of the proposed transnational Calls, aligning with the Lighthouse Regions, that is, the Baltic and the North Sea Basins, Black Sea, Atlantic/Arctic, and Mediterranean Sea along with their associated rivers.

EOSC-ENTRUST: A European Network of TRUSTed research environments

The mission of EOSC-ENTRUST is to create a European network of trusted research environments for sensitive data and to drive European interoperability by joint development of a common blueprint for federated data access and analysis. 
Countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policy-driven analysis of sensitive datasets such as people's health and socio-economic status, the habitats of vulnerable species and geo-spatial locations of protected sites. There are now a large number of such secure environments in operation - linked to national centres, individual organisations or specific research communities. This fragmented landscape poses challenges for both users and providers: researchers are faced with a large number of different systems and access procedures; providers need to manage federated access across multiple, potentially incompatible, technology and governance frameworks.
EOSC-ENTRUST brings together providers of operational Trusted Research Environments from 15 European countries with a shared goal to implement, validate and promote their capabilities through a common European framework using shared standards and common legal, operational and technical language. This blueprint for interoperability is anchored in the EOSC Interoperability Framework spanning the four dimensions of Legal, Organisational, Technical and Semantic interoperability. EOSC-ENTRUST has identified four driver projects covering Genomics, Clinical trials, Social science, and public-private partnerships to benchmark capabilities, inform blueprint design and demonstrate secure  data analysis using federated workflows.
Targeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a long-term operational TRE framework within the European Open Science Cloud.


Providing research infrastructure services to support Next Generation EU

This four-year project will harness outputs from key social science RIs in Europe and other reliable sources to support the aims of the ‘Next Generation EU’ programme and to inform EU youth policy. Virtual access will be provided to the outputs through special installations (portals) developed during the project. The core of the proposal is a set of existing research ‘services’, which will be re-purposed and customised to focus directly on the five themes: Make it Green; Make it Digital; Make it Healthy; Make it Strong; and Make it Equal. 

For each area, the consortium will work collaboratively to produce seven sets of resources:

i)	A searchable inventory of relevant variables drawn from multiple cross-national datasets; 

ii)	Analytical summaries, suitable for policy makers and analysts new to the field, as well as interactive resources available through the project portal;

iii)	Harmonised and merged extracts from these datasets that reduce the burden on analysts and increase sample sizes;

iv)	New data collected through the ESS’s established CRONOS web panel infrastructure. Eleven countries will field five waves of the panel, each one dedicated to a NextGenEU theme. Free and rapid access to the data will be available through the CRONOS portal alongside analytical summaries;

v)	In-person and virtual deliberative forums with young people (aged 18-34) in four countries covering the five Next Generation EU’ themes;

vi)	An educational tool (E-NextGen) channelling our data for use in classrooms and by the general public;

vii)	Comprehensive training materials related to all project outputs.


Midlene fra MATPROG-Matprogrammet: Norsk mat fra sjø og land fordelt på år

Midlene fra MATPROG-Matprogrammet: Norsk mat fra sjø og land fordelt på fylker

Midlene fra MATPROG-Matprogrammet: Norsk mat fra sjø og land fordelt på fagområde

Senior Research Scientist

This project aims to evaluate the extent to which water is a potential source of foodborne pathogens on Norwegian vegetables, particularly lettuce, that are eaten raw. The goal is to suggest practical means to reduce the risk. This is because water is use d in all steps in the production of lettuce, from irrigation to washing of the ready-to-eat product, and its contribution to the total microbial load is only partly investigated. In Norway, the irrigation water is usually surface derived with a variable b acteriological quality. The aim of WP1 is to investigate the influence of water on the bacteriological quality of lettuce from the field to the table. This will be achieved by studying in detail the irrigation water, including the contribution of biofilm from the pipes, and lettuce after irrigation. It is also vital to study the survival of faecal indicators on lettuce grown under natural conditions. During the survival trial, the effect of simple pre-filters and UV-treatment of the irrigation water will also be tested. The results from WP1 together with data from the literature will be included in the construction of a probabilistic quantitative model for contamination of lettuce with the pathogens carried by the irrigation water. The model constructed i n WP2 may be used to estimate the effect of preventive measures that are suggested in WP3. WP3 will also include assessment of water source protection, irrigation treatment and disinfection during washing of pre-cut lettuce, and also practical testing of different potential disinfectants. The expected outcomes of this project are that the producers, industry and authorities are provided with guidelines for irrigation water, that potential preventive measures are evaluated both in a quantitative model and also in practice. The results from this project will also contribute internationally to increased knowledge about the contamination routes of vegetables.

Irrigation water as a potential source of foodborne pathogens in vegetables consumed raw with special focus on lettuce

Atrieflimmer er en viktig risikofaktor for hjerneslag. Behandling med antikoagulasjon (’blodfortynnende legemidler’) reduserer risikoen betydelig, men kan også føre til blødningskomplikasjoner. Kliniske retningslinjer anbefaler å balansere risikoen for hjerneslag mot risikoen for blødning ved valg av blodfortynnende behandling eller ikke. Det er en utfordring for leger å holde oversikt over hvordan hjerneslagrisiko endres over tid. 
Prosjektet har som mål å identifisere angrepspunkter og bedre verktøy for mer effektiv, presis og persontilpasset forebygging av hjerneslag hos pasienter med atrieflimmer. Prosjektet vil benytte anonymt sammenstilte helsedata fra en rekke ulike nasjonale registre. Her vil vi beregne individuell risiko for hjerneslag hos pasienter med atrieflimmer, samt hvordan denne endres dynamisk over tid. Prosjektet vil studere om det er særlige særtrekk ved enkelte pasientforløp som ender i sykehusinnleggelser for hjerneslag hos atrieflimmerpasienter. På denne måten håper vi å identifisere forløp med potensiale for bedre forebygging. Vi vil videre undersøke ulikhet i bruk av helsetjenester blant atrieflimmerpasienter, for å identifisere grupper som kan ha behov for mer målrettede forebyggende tiltak. Og til slutt vil vi undersøke om et registerbasert verktøy for hjerneslagrisiko kan ha potensiale for å veilede og forbedre kliniske beslutninger for slagforebygging hos pasienter med atrieflimmer. 
Prosjektet er et samarbeid mellom forskere innen epidemiologi, statistikk og helseøkonomi og samarbeidsaktører som skal bruke kunnskapen, fra pasientorganisasjoner til allmennpraktikere. Et langsiktig mål for prosjektet er å kunne bidra til innovative registerbaserte verktøy som kan brukes som beslutningsstøtte av allmennpraktikere innenfor rammene av eksisterende elektronisk pasientjournal. Det vil også utforskes hvorvidt pasienter selv kan ha nytte av tilgang til slik informasjon.

Atrial fibrillation (AF) is an important risk factor for stroke. Anticoagulant treatment reduces the risk substantially but may also lead to haemorrhagic complications. The recommended approach is to balance the risk of stroke against the risk of bleeding. It remains a clinical challenge to keep track of temporal changes in stroke risk in AF patients and decide for anticoagulant treatment or not. Recent registry data have indicated stable rates of ischemic stroke in atrial fibrillation patients, while rates of haemorrhagic strokes are increasing. There is an urgent need to establish more targeted and tailored preventive measures within the primary and secondary healthcare services.
Based on a novel clinical application of data-driven methods from real-life registry data, the project has the ambition identify targets and tools for more efficient, precise and personalized stroke prevention in AF patients. The current project will study clinical patterns of risk factors and treatment preceding hospitalizations for acute stroke in AF patients to identify potential action points to improve decision-making for stroke prevention.  We will further explore any disparity in health care follow up of AF patients to identify groups in need of more targeted preventive measures. Finally, the project will investigate whether a dynamic, personalized register-based stroke risk scoring tool can guide and improve clinical decision-making for stroke prevention in atrial fibrillation patients. 
Using an interdisciplinary approach, the project combines research traditions from epidemiology, biostatistics, health economics, and social medicine, and include user expertise from clinical specialist medicine, clinical general practice, interaction across sectors of care, quality tool development in general practice, in addition to technological solutions for innovation and development of primary care electronic medical records.

Registry tool for stroke prevention in atrial fibrillation in Norway – RegTool AFNOR

Prosjektet har som formål å belyse utviklingen av ikke-smittsomme sykdommer (NCD) inkludert mental helse, muskel-skjelettsykdommer (her: hoftebrudd) og omfanget av det å ha mer enn en NCD (multimorbiditet), inkludert medisinbruk (polyfarmasi). Vi vil identifisere mulige underliggende årsaksforhold og ulike risikofaktorers betydning for utviklingen. Vi vil belyse betydningen av ulike livsforhold som sosioøkonomisk posisjon, familiesituasjon og bosted for å etablere ny kunnskap om hvordan psykisk helse, helseatferd og biologiske markører ("sårbarhet") påvirker risikoen for utviklingen av ikke-smittsomme sykdommer i et livsløpsperspektiv

Så langt har prosjektet brukt tid på å kvalitetssikre datakildene, bygge opp infrastruktur for behandling av data og samordnet forskergruppen inkludert alle partnerne og aktiv brukermedvirkning. I tillegg har vi involvert kliniske miljøer for å definere sykdomsutfallene. I foreløpige analyser har vi studert hvordan ulike helseregistre fanger opp personer registrert med en NCD i perioden 2008-2020. I tillegg har vi belyst andelen som er registrert med en, to, tre eller flere NCD?er i befolkningen. 

Forskningen vil gi ny kunnskap på NCD-området som vil identifisere arenaer for strukturelle og mer målrettete tiltak og effekter av tiltak på lokalt og nasjonalt nivå. Dette vil styrke det norske folkehelsearbeidet på sentrale områder beskrevet i Helse ? og omsorgsdepartementets Folkehelsemeldingen (2019).

The preventive potential of NCDs is traditionally estimated separately for each NCD, but the lifetime risk of NCDs, and how these diseases co-occur are uncertain, as are the role of clustering of life conditions, common risk factors, biomarkers and mental health throughout the life course. Thus, we need a novel approach to achieve new knowledge in the promotion and prevention of NCDs. Our concept include consolidation of NCD endpoints across somatic disciplines, examining joint and interacting effects of socioeconomic circumstances, life conditions, health behaviours, biological markers and mental health throughout the life-course. We will utilize the largest and most comprehensive population based long-term prospective cohorts and mandatory national registers, biobanks, and do comparable analyses to test similar hypotheses in independent datasets with individual data to elucidate plausible underlying causal mechanisms - to identify targets for prevention. Our approach, first using regional population based cohorts linked to national registers and then statistical methods will for the first time provide adjusted analyses applicable for the complete Norwegian population. 
Main objective: WP 1 To identify patterns of NCD occurrence, multimorbidity and polypharmacy of NCDs to recognise underlying potential causal mechanisms by integrating social contexts and biomarkers and do cost-effectiveness analysis. WP2 To contribute to a better understanding on how socioeconomic position (SEP) ultimately translates into inequalities in health. 
Our project will be among the first with this wider perspective taking shared risk factors among NCDs into account and make the results applicable for the complete Norwegian population.

0 antall prosjekter

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Registry tool for stroke prevention in atrial fibrillation in Norway – RegTool AFNOR

Tildelt: kr 12,5 mill.

Prosjektperiode: 2023-2026

Sted: Oslo

BEDREHELSE-Bedre helse og livskvalitet

A life-course approach to prevent noncommunicable diseases in an ageing population - NCDNOR

Tildelt: kr 16,0 mill.

Prosjektperiode: 2021-2026

Sted: Oslo