ISPNATTEK-ISP - naturvit. og teknologi

Advanced synthetic organic chemistry directed towards bioactive natural products

Naturen inklusive havet, er en rik kilde til bioaktive molekyler og mulige legemidler. De fleste bioaktive marine naturprodukter kan bare isoleres i svært små mengder og bioprospektering må kombineres med avansert organisk syntese hvis det sanne potensiale til disse kjemisk komplekse stoffene ska...

Tildelt: kr 6,9 mill.

Prosjektperiode: 2011-2017

Sted: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Design, synthesis and biological evaluation of selective antagonists for the various adenosine receptors

Adenosine is a signaling substance, which mediate its effects by activation of fours different G-protein-coupled receptors (GPCR) (A1, A2A, A2B and A3). The receptors differs in their affinity for adenosine as well as their downstream signaling pathways a ctivated in the target cells. The ARs are...

Tildelt: kr 1,9 mill.

Prosjektperiode: 2009-2011

Sted: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Synthetic studies directed towards asmarines and other purines with fused heterocyclic systems

Nature is a rich source of bioactive compounds and potential drugs. The so-called secondary metabolites are structures involved in interaction between organisms, for instance chemical defense. Studies of such metabolites have led to the discovery of many life-saving drugs, including antibiotics, ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2008-2012

Sted: Oslo

KOSK-II-Katalyse og org.synt.kjemi II

Synthesis Directed towards Development of Potential Antituberculosis Drugs with Novel Mechanism of Action

Tuberculosis (TB) is the major cause of death from a single infectious agent among adults in developing countries. Human immunodeficiency virus (HIV) infections have further increased TB morbidity and mortality. It has been estimated that ca. 30 million p eople will die from tuberculosiswithin th...

Tildelt: kr 3,7 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRINAT-Matematikk og naturvitenskap

Synthesis of Agelasines, Asmarines and Analogs, and Evaluation of Their Bioactivities

Project summary Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) and asmarines are neutral purine derivatives isolated from Raspaila sp. sponges. These two classes of purine natural products are structurally related; they both contain terpenoid side chains. Up t...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

KOSK-Katalyse og organisk syntetisk kjemi

Synthesis of Agelasines and Analogs, and Evaluation of Their Bioactivities

Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) and asmarines are neutral purine derivatives isolated from Raspaila sp. sponges. These two classes of natural products are structurally related; they both contain terpenoid side chains. Up till now only a few agel...

Tildelt: kr 0,72 mill.

Prosjektperiode: 2005-2006

Sted: Oslo

KOSK-Katalyse og organisk syntetisk kjemi

Synthesis of agelasines and evaluation of their antimycobacterial activity

Tuberculosis (TB) is the major cause of death from a single infectious agent among adults in developing countries and there has been a revival of TB in the industrialized world. Multidrug-resistant tuberculosis defined as resistance to the two most import ant drugs, isoniazid and rifampicin, is a...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2002-2007

Sted: Oslo

KOSK-Katalyse og organisk syntetisk kjemi

Synthesis of Plant Hormones with Growth Stimulating Effects

This project includes studies directed towarad synthesis of plant growth stimulators, concentrating on two classes; brassinosteroids and cytokinins. The high interest for brassinosteroids in the scientific community comes from the possibility that they can improve crop yields, overcome environmen...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2000-2005

Sted: Oslo