0 antall prosjekter

Dato fra ny til gammel

JPND-EU Joint Programme - Neurodege

Synaptic circuit protection in AD and HD: BDNF/TrkB and Arc signaling as rescue factors

Prosjektet sikter på å belyse årsaker til hjernesvinn, ved Alzheimers demens og Huntingtons sykdom. Spesifikt vil vi forstå hva som går galt med hjernens kontroll mekanismer for plastisitet. Det er kjent fra før at svikt i funksjonen av vekstfaktoren BDNF er et fellestrekk ved flere ulike hj...

Tildelt: kr 4,4 mill.

Prosjektperiode: 2016-2020

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular control of Arc protein: Decoding a master regulator of synaptic plasticity and cognition

Prosjektet har som overordnet mål å belyse hvordan minner kan dannes gjennom påvirking av nervecellenes signaler. Nerveceller snakker med hverandre ved små kontakpunkter, såkalte synapser. En nervecelle frisetter et kjemiskstoff (transmitter) som stimulerer neste nervecelle. Denne prosessen er kr...

Tildelt: kr 12,6 mill.

Prosjektperiode: 2016-2021

Sted: Vestland

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Decoding Synaptic Memory with TimeSTAMP

Prosjektet belyser grunnleggende mekanismer for endringer i nervecelle kommunikasjon som ligger til grunn for hukommelse. Endinger i nervecelle signaloverføring ved synapser er nødvendig for hukommelse og langvarige endringer i atferd. Denne evnen er svekket eller forstyrret ved en rekke psykia...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2013-2017

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Arc and the molecular control of LTP consolidation in vivo

The brain extracts information about the world that shapes our behavior and ultimately influences who we are as individuals. The immense capacity and specificity of memory storage in the mammalian central nervous system is thought to depend on the plastic ity of synaptic connections. Recent break...

Tildelt: kr 8,0 mill.

Prosjektperiode: 2011-2015

Sted: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

A systems biological approach to elucidate local protein synthesis code in synaptic plasticity and memory

This project is a systems biological approach to understanding how regulation of protein synthesis in neuronal subcompartments mediates long-lasting changes in synaptic communication and memory. The project consists of four interactive modules and 8 work packages (WPs). The experimental strateg...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2010-2013

Sted: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

ESF - Stress and Mental Health (EuroSTRESS) - støttes av NevroNor

Repetitive and uncontrollable stress is known to be a powerful risk factor for mental disorders. Whether an individual will respond adaptively or maladaptively to a stressor is de?ned by his/her genetics, developmental history and the environment in adult hood. In particular traumatic experiences...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2008-2013

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular mechanisms of LTP consolidation in vivo

The ability of the brain to store information stems from the fundamental plasticity of neuron-to-neuron communication at synapses. Rather than being static entities, synapses can undergo lasting increases or decreases in strength in response to specific i nput patterns. Synaptic plasticity is tho...

Tildelt: kr 5,5 mill.

Prosjektperiode: 2008-2012

Sted: Vestland

TU-Tungt utstyr

Multiphoton laser-scanning microscopy facility for in vivo subcellular imaging

We propose the establishment of a common facility for advanced multiphoton laser-scanning microscopy (MPLSM). The first of its kind, this facility integrating MPLSM with gradient refractive index (GRIN) microendoscopy and electrophysiological capability will be a critical instrument for leading ...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2008

Sted: Vestland

PSYKISK-Psykisk helse

The BDNF hypothesis of depression: a new framework for understanding depression and the actions of antidepressant drugs

Despite decades of research, the biological basis of major depression remains to be fully elucidated. Although antidepressants, such as serotonin reuptake inhibitors, rapidly increase serotonin levels in the extracellular space, the therapeutic effects of the drug are delayed by several weeks...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2005-2008

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Functional genomics of synaptic communication and memory storage

Memory is thought to be arise from enduring, plastic changes in the strength of synaptic communication. The core cellular event in this process is the synthesis of new mRNA and protein. The scientific aim of this project is to provide original insight int o the regulation of gene networks and pro...

Tildelt: kr 1,3 mill.

Prosjektperiode: 2003-2009

Sted: Vestland

BIOFYS-Fysiologiske og anatomiske fag

Molecular mechanisms of synaptic plasticity and memory consolidation

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Tildelt: kr 0,75 mill.

Prosjektperiode: 2003-2006

Sted: Vestland

PSYKISK-Psykisk helse

The neurotrophin hypotesis of depression: a new framework for understanding depression and the acion of antidepressant drugs.

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Tildelt: kr 2,0 mill.

Prosjektperiode: 2003-2006

Sted: Vestland