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Dato fra ny til gammel

IS-BILAT-Mobilitet Norge-USA /Canada

Regulation of a11 integrin: a promoter and focal adhesion study

Cells interact with the extracellular matrix via cell surface receptors called integrins. During the 10 past years we have systematically worked on one particular integrin that we have identified and characterized, the alpha11beta1 integrin. In 2007 we pu blished a paper describing a tooth erupti...

Tildelt: kr 51 000

Prosjektperiode: 2012-2012

Sted: Vestland

IS-BILAT-Mobilitet Norge-USA /Canada

Viral mediated manipulations of beta-adrenergic receptor subtypes modulate fear conditioning.

Memories are formed through changes in synaptic transmission in specific brain circuits. Evidence points to amygdala, and specifically its lateral nucleus (LA), as a key site of synaptic plasticity underlying fear conditioning, a leading model for studyin g neurobiology of emotional memory. In fe...

Tildelt: kr 0,34 mill.

Prosjektperiode: 2012-2012

Sted: Oslo

KLIMAFORSK-Stort program klima

Forest in south China: An important sink for reactive nitrogen and a regional hotspot for N2O?

Lystgass (N2O), en viktig klimagass, har vist økende konsentrasjoner i atmosfæren siden den industrielle revolusjonen. Lystgass dannes i jorda som et bi-produkt ved ulike nitrogen omsetninger. Det er først og fremst den globale intensiveringen av nitrogen omsetninger i jorda, både pga utstrakt br...

Tildelt: kr 8,5 mill.

Prosjektperiode: 2012-2015

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanistic, structural and regulatory investigations of unusual and artificial variants of chorismate mutases

Chorismate mutases (CMs) are enzymes that catalyze an essential reaction at the branching point of the metabolic shikimate pathway for the production of aromatic amino acids. As this pathway is confined to bacteria, fungi and plants, CMs therefore represent potential targets for highly specific a...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2012-2014

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Role of phosphatases in the regulation of mitotic exit

-I dette prosjektet skal vi undersøke hvordan celler deler seg. Streng kontroll med celledelingsprosessen er avgjørende for å unngå utvikling av kreft. I mange år har fokus vært på en gruppe av proteiner kjent som cyklin-avhengige kinaser, som fungerer som en motor for å drive celledeling. Disse ...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2012-2015

Sted: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Norwegian-Spanish cooperation to study human disturbance on brown bears. Applications for the conservation and management of bears in Europe

Understanding the effects of human activities on wildlife is challenging for large carnivores. During my PhD I studied effects of human activities on the behavior of brown bears, which showed fine-scale behavioral responses to human activities. Now I am l eading a project to compare bear behavior...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-BILAT-Mobilitet Norge-USA /Canada

Characterization of dSH3PX1 in Drosophila melanogaster

The aim of my exchange in Tom Neufelds lab is to study the role of the SNX18 fly homolog dSH3PX1 in vivo as part of my PhD thesis. The exchange period is scheduled from August 1st 2011 to December 31st 2011 (5 months). The main goal of my PhD thesis is to identify novel PI3P binding proteins req...

Tildelt: kr 92 000

Prosjektperiode: 2011-2011

Sted: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

The molecular basis for protein degradation and hydrogen production capabilities of Fervidicoccus fontis, a thermophilic crenarchaeon

The main goal of this project is to study the metabolism of thermophilic archaea by the analysis of its complete genome. The main object of the research will be a thermophilic archaea Fervidicoccus fontis isolated by Dr. Perevalova from hot spring of Kamc hatka (Perevalova et al., 2010). F. fonti...

Tildelt: kr 51 999

Prosjektperiode: 2011-2011

Sted: Ukjent Fylke

IS-TOPP-Toppfinans. av M.Curie-stipend

toppfinansiering til Fp7 People Marie Curie Action IEF grant Dr. Giorgio Zoppellaro

Marie Curie Action IEF grant Dr. Giorgio Zoppellaro need extra money to at least get Lønnstrinn 57 and 58. Dr. Giorgio Zoppellaro was earlier 2007-2008 at Lønnstrinn 57 at Univ of Oslo, but was forced down to Lønnstrinn 54 as an IEF, as founding is to low from a IEF MCA grant. The aim of the...

Tildelt: kr 0,11 mill.

Prosjektperiode: 2011-2011

Sted: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Chemometric approaches for the analysis of LC-MS based metabolomics data

The main objective of the project is to establish chemometric approaches for the analysis of LS-MS based metabolomics data. The project will include work to provide a pipeline for robust data processing of LC-MS based metabolomics data, to facilitate mea ns for biological interpretation of LC-MS...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Influence of anoxia on the marine acidification development: case study for the Inner Oslo Fjord (ANACID)

There is a gap of knowledge in estimating of the interconnection between the marine acidification and oxygen depletion developments.These oxygen depletion conditions depend on a combined effect of eutrophication (increase in nutrient load) and climate (in tensity of mixing and water renewal). Cli...

Tildelt: kr 38 999

Prosjektperiode: 2011-2011

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Understanding the role of nematode parasites in regulating the pestiferous Iberian slug, Arion lusitanicus, in Norway

The primary objective of this project is to understand the role of nematode parasites in regulating the pestiferous slug Arion lusitanicus in Norway. The invasive form of A. lusitanicus is believed to have originated from Portugal/Iberian Peninsula hence the common name Iberian slug. The specie...

Tildelt: kr 38 999

Prosjektperiode: 2011-2011

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Assess the role of the mitochondrial-nuclear connection in modulating neuronal autophagy

Backround and R&D challenge: Friedreichs ataxia (FRDA), the most frequent inherited recessive ataxia, causes nervous system damage and movement problems, it is ascribed to severely defective expression of frataxin, a nuclear-encoded mitochondrial protein . Autophagy is not only the major pathway...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Analysis of genetic diversity and population subdivision of Halys pit-viper (Gloydius halys) at the different spatial levels

Genetic diversity is one of the most important factors affecting viability of populations. Loss of genetic diversity can lead to inbreeding depression, reduction of the adaptive potential and weak tolerance of population to diseases, parasites and other s tressors. Thus, the understanding of how ...

Tildelt: kr 90 999

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Assesment of cardioprotection provided by intramyocardial or subcutaneous transplantation of human adipose stem cells overexpressing HMOX-1

Stem cells are currently explored as therapy against heart failure. However, several unsolved issues still remain, namely the survival of cells post-transplantation, the role of local environmental conditions on the fate of transplanted cells, or mechanis ms by which stem cells improve cardiac fu...

Tildelt: kr 0,12 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Role and regulation of Ca2+ flux during the cell-cell fusion occurring in the human placenta

The cell-cell fusion processes are complex biological phenomena. A limited number of human cell types can fuse to form a multinucleated syncytium. In the differentiation of human placenta, mononuclear cytotrophoblasts aggregate and fuse to form an endocri nologically active, non-proliferative, mu...

Tildelt: kr 90 999

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Community dynamics of methanogenic archaea in a rapidly changing peatland ecosystem in the zone of discontinuous permafrost in North-Norway

Northern palsa peatlands and permafrost landscapes are already subjected to distinct geomorphological and biogeochemical changes due to the atmospheric warming as it is predicted to occur faster and stronger especially in the northern latitudes. It is als o known that these environments harbor a ...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Socially and corticosterone mediated differences in individual helping behaviour in a cooperatively breeding bird

In cooperative breeding, helpers contribute to raising offspring that are not their own. Despite the success of theories such as kin selection in explaining broad patterns of helping, large amounts of within- and between-individual variation in helping ef fort remains unexplained. Much of this pr...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Systematics and biogeography of Labrundinia Fittkau, 1962 (Diptera: Chironomidae: Tanypodinae): a morphological and molecular approach

The basis of this study rests on the examination of the type material of all previously described Labrundinia species (Insecta: Diptera: Chironomidae: Tanypodinae), including species deposited in national and foreign museums. Field work has been carried o ut in Brazil to collect more specimens an...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

New parasites from old fish

Natural history collections preserve a record of biodiversity in time and space within their archives of carefully described and catalogued reference specimens. However, they also contain a further resource; the numerous poorly-known parasitic and symbiot ic taxa collected unwittingly and preserv...

Tildelt: kr 90 999

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EVOLUTION, MAINTENANCE, AND POPULATION DYNAMICS OF NATURAL COMPETENCE, CANNIBALISM, AND MARTYRDOM IN BACTERIA

In this proposal we set out to test alternative hypotheses for the evolution and maintenance of natural competence for transformation, as well as cannibalism and martyrdom in bacteria. These two processes are fascinating strategies for bacterial adaptatio n and survival. An increased understandin...

Tildelt: kr 6,3 mill.

Prosjektperiode: 2011-2015

Sted: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cell-to-cell communication: Mechanism of tunneling nanotube formation and function

1)Vi undersøkte hvordan filopodier utvikler seg til nanorør. Myosin X, et motorprotein, ble vist å være en integral del av nanorør. Myosin X induserte filopodier og samlet adhesjons molekyler på tippen av filopodier og berøringsstedet mellom nanorør og celle. Myosin X knockdown og ekspresjon av d...

Tildelt: kr 7,8 mill.

Prosjektperiode: 2011-2015

Sted: Vestland

IS-BILAT-Mobilitet Norge-USA /Canada

Safety Issues Associated with Antibiotic Resistance Hazards and Discovery of Safer Antibiotics Targeting Bacterial Purine Biosynthetic pathw

The rapid increase in resistance to current antibiotics strongly motivates the development of new antimicrobials with alternate modes of action. In eukaryotic systems, PurK and Class I PurE are substituted by a Class II PurE, which directly converts AIR i nto CAIR. Bacterial PurE and PurC also di...

Tildelt: kr 0,21 mill.

Prosjektperiode: 2011-2011

Sted: Troms - Romsa - Tromssa

IS-DAAD-Forskerutveksl. Norge-Tyskland

Modelling NAD metabolism and its connection to the circadian clock

Most biological processes require energy and are tightly regulated. Energy is extracted from food supplies and eventually transformed into ATP, the universal energy carrier of the cell. These pathways consist of many reactions which involve NAD or NADP, s mall molecules which serve as intermediat...

Tildelt: kr 35 141

Prosjektperiode: 2011-2013

Sted: Vestland

IS-DAAD-Forskerutveksl. Norge-Tyskland

Molecular signatures of long non-coding RNAs in breast cancer patients

Of the ~3.3 billion bases of the human genome, only about 2% code for proteins and until very recently, the remaining 98% have been considered to be 'junk'. However, large transcriptomic studies have shown that around 90% of the genome is actively transcr ibed of which a significant fraction may ...

Tildelt: kr 37 386

Prosjektperiode: 2011-2013

Sted: Oslo

IS-DAAD-Forskerutveksl. Norge-Tyskland

Molecular Identification of Porin Channels in Plant Peroxisomes by Electrophysiological Analyses

Plant biomass production needs to increase world-wide to feed the growing world population and to meet the demands for cellulose-based biofuels. However, plant photosynthesis is inefficient because it is accompanied by photorespiration, which releases up to 30% of fixed carbon as CO2 in higher p...

Tildelt: kr 13 257

Prosjektperiode: 2011-2012

Sted: Rogaland

IS-AUR-Samarb.progr. Norge Frankrike

Genomic dissection of seed development

Parent of origin dependent expression plays an important role in seed development of flowering plants, and disruption of imprinted genes typically leads to developmental abnormalities often resulting in abortion of the seed. We have used a mutant in the A rabidopsis Cdc2/CDC28 homologue, CDKA;1 a...

Tildelt: kr 97 853

Prosjektperiode: 2011-2013

Sted: Oslo

IS-TOPP-Toppfinans. av M.Curie-stipend

FP7 TNT-Function

Søknad om toppfinansiering av Marie Curie postdoc for å kompensere for differansen mellom Marie Curie ordningens Living Allowance og norsk tarifflønn.

Tildelt: kr 0,17 mill.

Prosjektperiode: 2010-2012

Sted: Vestland

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Secretion and anchoring of inhalant allergens in Lactobacilli.

The present project concerns a research visit of a young researcher working at Belgrade University to the Norwegian University of Life Sciences in Ås. The visiting researcher is working in an allergology centered laboratory, and is working on recombinant allergens. The host lab in Norway has ext...

Tildelt: kr 84 999

Prosjektperiode: 2010-2011

Sted: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Proteomics analysis of peroxisomes from pepper fruits: Functional analysis of antioxidant peroxisomal enzymes

Pepper (Capsicum annuum L.) is the second worldwide consumed vegetable and is characterized by its high levels of vitamin C (ascorbic acid), vitamin A (pro-carotene) and calcium. Mature pepper fruits are also rich in carotenoids, which are compounds with antioxidant and anticancinogenic capacity...

Tildelt: kr 33 999

Prosjektperiode: 2010-2010

Sted: Ukjent Fylke

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