0 antall prosjekter

FRIBIO-Biologi og biomedisin

The dynamic interstitial matrix and transcapillary exchange: Normal function and pathophysiology

The focus of this application is how the extracellular matrix can influence transcapillary transport of water and protein. The separate projects are closely related and cover studies from the level of single cells and organs to the organism. The unifying concept is the hypothesis that extracellu...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Molecular characterization of embryonic microenvironment that stimulates adult human hematopoietic stem cells to differentiate into neurons

Recent research from the applicant and colleagues has shown that adult human hematopoietic stem cells, derived from bone marrow biopsies, can be stimulated to differentiate into nerve cells by placing them into the injured spinal cord of a chicken embryo. The injured embryonic spinal cord regen...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

The role of Natural Killer cells in defense against pathogens.

Natural Killer (NK) cells represent an efficient first line defense mechanism against infected cells and certain cancer cells. For this purpose each NK cell is equipped with an array of activating and inhibitory receptors recognizing MHC class I and other molecules on their target cells. Althoug...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

The Biosynthesis of NAD in Humans: Isozymes and Subcellular Compartmentation

NAD is essential for energy transduction. It is also a key molecule in a variety of central signaling pathways. Nevertheless, surprisingly little is not known about its biosynthesis. Our recent research has established that NAD biosynthesis is absent from the cytosol: the three human isoforms of...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Studies of mesenchymal cell function during development and disease using transgenic techniques.

Cells interact with collagens using specific cell surface protein receptors belonging to a family called integrins. We have identified one collagen-binding integrin (alpha11beta1), characterized its structure and are studying its function using genetical ly modified mice lacking alpha 11 integri...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

BIA-Brukerstyrt innovasjonsarena

A novel antimicrobial agent for topical treatment of challenging infections caused by drug-resistant bacteria.

"Once life-saving medicines are increasingly having as little effect as a sugar pill. Since 1970, no new classes of antibacterials have been developed to combat infectious diseases. Microbial resistance to treatment could bring the world back to a pre-an tibiotic age." WHO Report 2000: Overcomi...

Tildelt: kr 8,8 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Overvekt, insulinresistens og inflammasjon i relasjon til fettinntak og fettkvalitet

Det er en stadig økende forekomst av overvekt og type 2 diabetes mellitus i Norge og verden forøvrig. Som produsent av næringsmidler med høyt innhold av fett ønsker Mills å få økt kunnskap om fettets betydning for disse sykdommene med det formål å kunne u tvikle produkter som har forebyggende eff...

Tildelt: kr 1,7 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Entry of Nanoparticles into cells: Characterization of Nanoparticles as tools to study endocytic pathways..

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Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2010

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

The importance of post-translational glycosylation in the secretory pathway for expansion of the functional repertoire of gene products

Most proteins in animal and plant cells are glycosylated, a fact that must be taken into account for all aspects of protein studies, because the glycan portion often influences protein activity and cellular targeting, and more practically, protein purific ation, crystallization and structural det...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Biological Role of Regulatory Catalytic RNA in Eukaryotic Protein Gene Expression

A new main category of catalytic RNA (the GIR1 ribozyme) has been discovered and is under investigation in our laboratory. The group I-like ribozyme (GIR1; approx. 200 nt) is a unique example of a naturally occurring ribozyme with an evolved biological fu nction. GIR1 generates the 5'-end of a nu...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2011

Sted: Troms - Romsa - Tromssa

BIA-Brukerstyrt innovasjonsarena

Development of mechanism based, novel anti-inflammatory compounds

Avexxin AS (founded in Trondheim march 2005) introduces a novel therapeutic approach for the treatment of chronic diseases including psoriasis based on more than a decade of research at Prof. Berit Johansen?s group at the Norwegian University of Science a nd Technology. The new compound interfere...

Tildelt: kr 7,8 mill.

Prosjektperiode: 2006-2009

Sted: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

Høysensitiv nanopartikkelbasert homogen assayteknologi for analytter med høy molekylvekt

Det skal utvikles en høysensitiv nanopartikkelbasert homogen assayteknologi for konsentrasjonsbestemmelse av analyttermed høy molekylvekt. Slike immunoassays er raskere, og har mye større markedsvekst enn langsomme, kostbare separasjonsbaserte assays. De har tidligere blitt utviklet for analytter...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Østfold

BIA-Brukerstyrt innovasjonsarena

Utvikling og klinisk uttesting av et implantat til bruk på pasienter med ileostomi (utlagt tynntarm)

I FoU-prosjektet skal det utvikles og klinisk uttestes et implantat som skal gi pasienter med ileostomi forbedringer hva gjelder både medisinske komplikasjoner og livskvalitet. Et velfungerende stomiimplantat med et tømmesystem som også kan tillate posef rie perioder, vil representere en betydel...

Tildelt: kr 6,5 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FRIBIO-Biologi og biomedisin

Coeliac disease (CD) and rheumatoid arthritis (RA); mapping the shared features in order to understand autoimmunity

There has been a huge advance in the understanding of coeliac disease (CD) in recent years. Our group has made several important contributions to this improved understanding. Research done by other groups has started to unravel aspects of the pathogenesis of rheumatoid arthritis (RA) that at sev...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Quorum sensing and transcriptional regulation in Gram-positive bacteria.

The bacteriocin production in Lactobacillus plantarum is regulated by the pln regulatory unit which is a quorum-sensing based signal transducing pathway. Such quorum-sensing based regulatory systems are of crucial importance in regulating gene expression in bacteria in response to environmental c...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapeutic approaches for the correction of misfolding mutations in pterin-dependent enzymes

Many inherited diseases are caused by the enhanced tendency of the mutant variant proteins to misfold and to either undergo proteasomal degradation or deleterious aggregation with plaque formation. For several of these diseases evidence has been accumulat ed that chemical or pharmacologic chapero...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2006-2012

Sted: Vestland

FRIBIO-Biologi og biomedisin

Glutamate and lactate: Jason-faced actors in neurology

Excitatory amino acids play dual roles in the brain: they are physiological transmitters but have the potential to damage brain tissue. The same may be true for lactate, an important intermediate in cell metabolism. The project will study the roles of exc itatory amino acids and lactate transport...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Dynamic 3-D modelling of the synaptic environment: The roles of transporters in controlling receptor activation and water transport

Prevention and cure of neurological diseases are hampered by a lack of knowledge of the underlying pathogenetic mechanisms which involve a complex system of transporter proteins. The primary objective of this proposal is to uncover how transporters limit activation of brain neurotransmitter recep...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

PPAR activation and mitochondrial function in obesity related diseases.

Disorders of lipid metabolism are intimately connected to many common, life-style related diseases. Obesity and obesity-related disorders, often referred to as the metabolic syndrome, is a serious condition with the presence of a number of risk factors li ke overweight, dyslipidaemia, hypertensio...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2010

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cell cycle regulation: the role of replication clamps and interacting proteins

DNA replication is executed by enzymes called polymerases. The polymerases are tethered to the DNA template by binding to so-called clamps, which are doughtnut-shaped protein complexes encircling the DNA. The clamps are being loaded onto the DNA by clamp loaders, another protein complex. All orga...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2006-2013

Sted: Oslo

GLOBHELS-Global helse

Alternative Treatment Strategies in HIV Infection - research platform with integrated biological and clinical objectives

By combining complementary expertise held by our groups and collaborators both nationally and internationally, we will coordinate development of a HIV clinical platform for translational research which is particularly important in HIV infection: Relevant animal models are unavailable, studies of ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2010

Sted: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Mechanisms of hyperglycemia-induced foam cell formation and atherosclerosis in type-2 diabetes. Role of the hexosamine biosynthetic pathway

Vascular disease is the most common cause of death in people suffering from type 2 diabetes. The high risk of atherosclerotic disease in type 2 diabetes can in part be accounted for by the diabetic state per se, such as hyperglycemia. Uptake of oxidised LDL and accumulation of cholesterol esters...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

GLOBHELS-Global helse

Development of a subunit vaccine for prevention of reactivation of tuberculosis

Mycobacterium tuberculosis causes tuberculosis and is one of the main killers among infectious pathogens in the world, and an important factor that sustain poverty in developing countries. Applied research for development of new vaccines is therefore need ed. Transmission of tuberculosis (TB) is ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Mechanisms behind pathogen activation and evasion of Toll-like receptor signaling

Toll-like receptors (TLRs) are signaling receptors of the innate immune system, sensing a variety of bacterial and viral components. Our central hypothesis is that immune cell recognition of invading pathogens starts with an interaction between microbial structures and TLRs. The following immune ...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2005-2011

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Endothelial cell differentiation - a key to future therapy of chronic inflammation and cancer

Much attention is focused on understanding the role of vascular endothelial cells in disease. In several fields of medicine, there is great interest in understanding the mechanisms that regulate the generation of new vessels and endothelial cell different iation, because the future ability to man...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2005-2009

Sted: Oslo

NANOMAT-Nanoteknologi og nye materialer

Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces

Project: Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces Recently we have discovered that mammalian cells are connected by thin membrane tubes. These tubes with a diameter of 50 to 200 nm are referred to as tu nneling nanotubes (TNTs). They are a cont...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2005-2010

Sted: Vestland

PSYKISK-Psykisk helse

ADHD in Norway: Basic and translational studies

Attention deficit hyperactivity disorder (ADHD) is a common condition among school age children world-wide. In addition, most affected individuals will continue to show symptoms as adults. Still, it has long been considered a controversial diagnosis in th e general population, as well as in the p...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2005-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Functional sites in proteins: A combined proteomic and bioinformatical approach for improvement of a prediction system for linear motifs.

Functional sites in proteins are short stretches of amino acids that serve as binding sites, post-translational modification sites or proteolytic cleavage sites. Most functional features of proteins can be related to functional sites and/or globular domai ns. While there are several efficient met...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2005-2009

Sted: Vestland

STORFORSK-Store forskerinitierte prosjekter

Multilevel analysis of memory formation in the entorhinal-hippocampal circuit

Neuronal networks within the medial temporal lobe are essential for fast encoding and storage of episodic memories in humans and other mammals. A key connection in this system is the perforant path (PP) which projects from the entorhinal cortex to the hip pocampus (including the dentate gyrus). S...

Tildelt: kr 19,6 mill.

Prosjektperiode: 2005-2010

Sted: Oslo

STAMCELLER-Stamcelleforskning

EuroSTELLS Project: Translational Stem Cell Research: From Basic Biology to Regenerative Medicine

This project involves the joined forces of 13 research groups from 6 countries with common interests and complementary competence in developmental biology, stem cell biology and regenerative medicine and cancer biology. The consortium aims at elucidating the mechanisms that control self-renewal a...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2005-2009

Sted: Oslo