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Dato fra ny til gammel

GNBIO-Grunnleggende næringsrettet bioteknologi

Exploring the T cell receptor genome - the next generation cancer immunotherapeutics

We will generate recombinant T cell receptors (TCRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cells that recognize telomerase have been isolated ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

IS-RUS-Stipendprogram for NVRussl.

Iyevleva, A RUS06/07-37

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Tildelt: kr 30 000

Prosjektperiode: 2007-2007

Sted: Oslo

PES-INST-Prosjektetablererstøtte EU (FoU)

Invivo ultrasonic transponder system for biomedical applications

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Tildelt: kr 49 999

Prosjektperiode: 2007-2007

Sted: Oslo

TJENESTER-Helse- og omsorgstjenester

Multiple drug therapy and coordination of drug prescription for the elderly

From the literature we know that the use of drugs in general and the occurrence of polypharmacy (usually defined as concomitant use of five or more drugs) in particular, has increased dramatically among elderly in the population. Often hospitals, private practising specialists and general practit...

Tildelt: kr 2,1 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Potential clinical relevance of radiation-induced signaling pathways

Radiation therapy is a commonly used treatment modality for cancer. Although in the past decades radiation therapy has shown to be a very successful treatment form, it still can be improved. One problem is that some tumors are particularly resistant to th e cytotoxic effects of radiation and resp...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

KLINISK-Klinisk forskning

Functioning disturbance in chronic back pain: Altered muscle activation pattern, muscle metabolism and pain-cognitions.

There is evidence that individuals with chronic non-specific back pain (CNSBP) show altered muscle activation patterns. It is unknown why these alterations in activation pattern occur, which consequences this may have for muscle metabolism and how they ar e linked to pain experience and developme...

Tildelt: kr 2,0 mill.

Prosjektperiode: 2007-2015

Sted: Vestfold

FRIBIO-Biologi og biomedisin

Modeling human disease in mice;DNA repair and genomic (in)stability.

Our research is currently focused on two classes of enzymes involved in repair, and possible regulation, of DNA and RNA species; flap endonuclease 1 (FEN1) and mammalian alkB homologs (ABHs). Genetic models are generated in order to elucidate the contribu tion of single gene deletions in genomic ...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

KLINISK-Klinisk forskning

Spontaneous firing activity in motoneurones of cervical paraspinal musculature in healthy subjects and in patients with neck pain

I prosjektet "Spontan elektrisk aktivitet i nerveceller til nakkemuskler hos friske frivillige og nakkesmertepasienter" forsøker vi å forstå mer av årsakene til nakkesmerter, ved å studere hvordan nerveceller i ryggmargen styrer nakkemusklene i ro og ved bevegelser. Vi ønsker å finne ut om disse...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2007-2014

Sted: Oslo

NANOMAT-Nanoteknologi og nye materialer

Uptake and toxicity of quantum dots in cancer cells

Most of the work on quantum dots has so far been focused on their production and fluorescence imaging. The possibility to use quantum dots as photosensitizers remains unexplored: Can these nanoparticles generate reactive oxygen species in biological envir onments? Such a potential of quantum dots...

Tildelt: kr 5,6 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Tumor Targeting Antibodies in Colorectal Cancer

Objective: The main purpose is to identify and characterize novel antibodies recognizing specific antigens on colorectal cancer cells. Interesting candidates will be thoroughly examined for their specificity and their ability to be used as diagnostic and/ or prognostic markers. Their potential as...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The role of mismatch repair proteins in origin sequestration

We have shown that DNA replication is tightly coupled to cell growth in wild type E. coli cells. Initiation of replication occurs precisely at the same point in the cell cycle, generation after generation. The molecular mechanisms behind the precise timin g of initiation of replication are not ye...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2007-2014

Sted: Oslo

FOLKEHELSE-Folkehelse

Energy Balance and Breast Cancer Aspects. A randomised clinical trial with physical activity interventio

Breast cancer requires intense and prolonged treatments often associated with significant side effects, also influencing their levels of physical activity after diagnosis. New evidence from large cohort studies supports a role of physical activity in redu cing recurrence and improving survival. A...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

KLINISK-Klinisk forskning

Does fusion lead to increased adjacent level disc degeneration in patients with chronic low back pain. An international collaborate project.

There is controversy as to whether fusion of one or more motion segments of the spine results in accelerated degeneration of the adjacent segment over time. Some argue that adjacent segment is exposed to increased mechanical stress, which accelerates disc degeneration, whilst others maintain tha...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

IS-NAD-Samarbeid med NORAD-land

El-Komy, Mohamed Egyptisk spes 2007

...

Tildelt: kr 25 701

Prosjektperiode: 2007-2007

Sted: Oslo

SFI-Sentre for forskningsdrevet innovasjon

CAST - Cancer Stem Cell Innovation Center

SUMMARY SFI-CAST has been established by the Research Council of Norway with the aim of using knowledge about stem cell biology to improve our understanding of cancer, and to develop new therapeutic tools. SFI-CAST was hosted by the Oslo University Hospital (OUS) with the University of Osl...

Tildelt: kr 80,0 mill.

Prosjektperiode: 2007-2015

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Targeting occult tumor cell dissemination in localised breast cancer

For the future, a better treatment of patients with breast cancer is dependent upon a better assessment of the individual risk of harbouring minimal residual disease after the completion of the surgical treatment. The aim is to separate very low risk pati ents from high risk patients for future m...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FORNY-3-Kommersialisering av FoUresultater

Infrastrukturmidler 2007- Rikshospitalet-Radiumhospitalet HF

Rikshospitalet - Radiumhospitalet HF (RR HF) har en klar målsetning om å utnytte resultater og oppfinnelser fra egen virksomhet kommersielt og søker med dette om Infrastrukturmidler for 2007. Medinnova og Radiumhospitalets Forskningsstiftelse deler i dag på de oppgavene som ligger i å være Tech...

Tildelt: kr 0,80 mill.

Prosjektperiode: 2007-2007

Sted: Oslo

STAMCELLER-Stamcelleforskning

Impact of DNA base lesion repair for stem cell maintenance

DNA damage (mutations) are the fundamental cause of all forms of cancer and a number of different but integrated processes operate to prevent genetic changes from occurring. These include cell cycle regulation, DNA replication, transcription, DNA repair, regulation and sanitation of nucleotide po...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

IS-DAAD-Forskerutveksl. Norge-Tyskland

Klungland, Arne daadppp 0708

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Tildelt: kr 0,14 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

INT-BILAT-BILAT-ordningen

USA: bilateralt samarbeid for å utvikle fagområdet Tissue engineering

Bakgrunn for fagfeltet: Fagområdet Tissue engineering (på norsk kanskje best oversatt med vevsregenerativ behandling) beskriver det forskningsarbeidet som tar sikte på å (gjen)oppbygge vev. Dette kan dreie seg om vev som ikke har eksistert, eller vev som har vært normalt men som har blitt skade...

Tildelt: kr 0,15 mill.

Prosjektperiode: 2007-2008

Sted: Oslo

IS-AUR-Samarb.progr. Norge Frankrike

Kristensen, Vessela Aurora 2007-08 Fransk-norsk forskerutveksling

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Tildelt: kr 60 000

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Study of cellular distribution and biological functions of neonatal Fc receptor in immune cells

Immunoglobulin G (IgG) is the major class of immunoglobulins and the protein with the longest serum half-life. IgG is also actively transferred to the fetus, giving the full-term fetus IgG levels over maternal levels and protective immunity. The MHC class I related neonatal Fc receptor (FcRn) is...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2009

Sted: Oslo

FRIBIO-Biologi og biomedisin

Mechanism of cargo selectivity in axonal transport Isolation and characterization of kinesin light chain associated vesicles

The aim of this project is to gain knowledge about how the motor protein kinesin-I interacts with its vesicle cargo, and what the nature is of the vesicles that are transported by kinesin-I through neurons. The role of neuronal transport in neurodegenerat ive diseases such as Alzheimer's disease,...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

STAMCELLER-Stamcelleforskning

Signaling in neural stem cells: implications for regenerative medicine and tumor biology

Stem cell biology is one of the most closely followed developments in biomedicine today. Stem cells may provide the foundation for rational regenerative therapeutics with far-reaching implications in the health sector, but give also new alleys in the unde rstanding of tumor biology. The central ...

Tildelt: kr 12,4 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

GLOBHELS-Global helse

Further Developments of New Immunogenic Peptide-based HIV Vaccines Targeting Dendritic Cells

Therapeutic HIV vaccines targeting dendritic cells have so far shown more promising results than preventive HIV vaccines and may become an alternative even for prophylaxis. This Proposal describes plans for basic clinical studies on further characterizati on and developments of new immunization s...

Tildelt: kr 7,4 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FORNY-3-Kommersialisering av FoUresultater

Infrastrukturmidler 2007 - SSHF

Sørlandet sykehus har deltatt i FORNY-prgrammet side 2004, og fikk infrastruktrmidler første gang i 2006. Hovedfokus i inneværende år har vært å etablere et rammeverk som består av infrastruktur, incentvordninger og styrende dokumenter. I 2007 vil det bl i lagt vekt på å videreutvikle og forankr...

Tildelt: kr 0,17 mill.

Prosjektperiode: 2007-2007

Sted: Agder

FRIMED-Klinisk medisin og folkehelse

The Tromsø Pain Study: Causes and consequences of individual differences in pain sensitivity

Human pain sensitivity is subject to very large inter-individual variation. It is known that pain sensitivity is heritable, but the genes involved are largely unknown. Hypersensitivity to pain may be an important risk factor in the development, maintenanc e and consequences of chronic pain. Reduc...

Tildelt: kr 3,7 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Combined structural, microvascular and functional mapping of brain tumors for improved diagnosis and treatment planning

During recent years, the department of radiology at Rikshospitalet-Radiumhospitalet (RR) Medical Center has had a strong focus on functional MRI (Magnetic Resonance Imaging) research; including perfusion/ diffusion MRI and spectroscopy, with the aim of br inging novel MR techniques into early cli...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

NANOMAT-Nanoteknologi og nye materialer

Entry of Nanoparticles into cells: Characterization of Nanoparticles as tools to study endocytic pathways and intracellular transport

Research on nanoparticles have evolved into biological applications with large expectations for the use of magnetic iron oxide nanoparticles and fluorescent Quantum dots in different imaging techniques both for tumor targeting and drug delivery in humans and as probes at the cellular level. In th...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2006-2011

Sted: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Studies of growth control and gene expression in normal and neoplastic B-lymphoid cells

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. The complex biology and the variety of genetic and epigenetic factors involved in the pathogenesis make lymphomas a challenging disease for translational resear ch. There a clear need for the developmen...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2006-2012

Sted: Oslo

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