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FUGE-Funksjonell genomforskn.i Norg

The Systems Biology of Breast Cancer

Systems Biology of Breast Cancer creates a world-class cancer research team, working systematically towards understanding of the biological dynamics of breast cancer. Breast cancer is a genetic disease; breast tumor genomes are dynamic and tumors are com plex systems shaped by gene aberrations, ...

Tildelt: kr 9,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional Genomics of Regulatory T cells - Novel Therapeutic Strategies for Immunomodulation

The main goal of the research plan is to understand how the immune system controls immune reactivity and balances self-tolerance versus an efficient immune defence. This could potentially lead to new understanding of key factors in the pathogenesis of hum an disease. Specifically, we aim to inves...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Cellular Mechanisms Templating Complex Extracellular Structures via Cellulose Scaffolds: the Oikopleura House

Extracellular matrices are a fundamental interface through which cells and organisms interact with their external environment. In some cases very complex 3-dimensional structures are formed and the extracellular matrix of plants is crucial in effecting de velopmental pattern formation. Cellulose ...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2006-2010

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Samarbeidsavtale mellom FUGE og FORNY for styrket innsats mot verifisering av bioteknologiprosjekter (188583/I10)

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Tildelt: kr 9,0 mill.

Prosjektperiode: 2006-2011

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Proteomic and bioinformatic studies of Mycobacterium tuberculosis

Tuberculosis (TB) is a major communicable disease linked to poverty with a substantial death toll of about 2 million cases annually. Research is needed to develop novel diagnostic tools, novel preventive measures such as vaccines and novel antibiotics. To do so it is of paramount importance to k...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2006-2010

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Dissecting the process of plastid division in higher plants using functional genomics approaches

Plant cells contain plastids, vital organelles representing the ultimate source of all food production. Plastids are not created de novo but arise by division from pre-existing cytosolic plastids but despite recent progress in the field new approaches are needed to unravel this fundamental biolo...

Tildelt: kr 7,2 mill.

Prosjektperiode: 2006-2011

Sted: Rogaland

FUGE-Funksjonell genomforskn.i Norg

Genesis of B lymphomas studied by functional genomics

Background: Idiotypes (Id) are antigenic determinants in the variable regions of immunoglobulins (Ig). We have previously demonstrated that B lymphocytes partially degrade their endogenous Ig and present Id-peptides on their Major Histocompatibility Compl ex (MHC) class II molecules to CD4+ T cel...

Tildelt: kr 5,8 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Use of functional genomic responses as an early warning of stress in the aquaculture environment

Stress levels in farmed Atlantic salmon need to be reduced to improve animal welfare and raise performance. However there are many factors causing stress and there are currently no reliable early warning tools that could be used to diagnose and take evasi ve action to minimise stress. Tests need ...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2006-2008

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Fine mapping and molecular characterisation of quantitative trait loci (QTL) affecting hernia in pigs

Hernia is shown to be a serious problem in pig production, causing severe economic loss for the pig producers. The most common types are inguinal/scrotal hernia (IH) and umbilical hernia (UH). IH refers to hernial contents present in the inguinal canal an d/or that organs protrude into the scrotu...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2006-2009

Sted: Innlandet

FUGE-Funksjonell genomforskn.i Norg

Developing blood-based gene expression tests for early diagnosis of Alzheimer's disease

Alzheimer's disease (AD) is the most common form of dementia affecting some 28 mill. people worldwide. Medical interventions in the pipeline that can delay the onset or progression of this disease will have enormous public health impacts. An accurate, obj ective, easy to use test for early detect...

Tildelt: kr 9,8 mill.

Prosjektperiode: 2006-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

New tools for bioinformatics - from sequences to literature

The demand for bioinformatics tools is increasing as the complete human genome sequence and more than 250 other complete genome sequences are available. Sencel Bioinformatics is carrying out research and development into methods for searching databases of nucleotide and protein sequences in orde...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2006-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Entry of Nanoparticles into cells: Characterization of Nanoparticles as tools to study endocytic pathways..

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Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2010

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

MedCoast Scandinavia arrangerer "the MedCoast Week" hvor vi konsentrerer formidlingen av Foreningens ulike aktivitets områder 2-4 november

MedCoast Scandinavia Week finner sted i Oslo 2-4 November 2005. Scanbalt Forum 2005 er hovedarrangementet. Se vedlagt program. Følgende aktiviteter utover selve Forumet knyttes til denne uken: *Internasjonalt fagseminar MedCoast Symposiet er omrking n evrologi og metabolisme. Store Auditorie...

Tildelt: kr 49 999

Prosjektperiode: 2006-2006

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Development of novel system for kinase analysis and autoradiography

The kinase analysis market is of substantial size involving both academia and pharmaceutical industry. More than 30% of all R&D spending in the pharmaceutical industry is focused on kinase analysis (Drug & Market Development Publications, 2003), especiall y in the areas of cancer, immune diseases...

Tildelt: kr 4,5 mill.

Prosjektperiode: 2006-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

The importance of post-translational glycosylation in the secretory pathway for expansion of the functional repertoire of gene products

Most proteins in animal and plant cells are glycosylated, a fact that must be taken into account for all aspects of protein studies, because the glycan portion often influences protein activity and cellular targeting, and more practically, protein purific ation, crystallization and structural det...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Combining biomarkers from salmon metabonomics, genomics and proteomics with high-field NMR profiling of fish feed nutrients

Improvements of salmon feed are complex and very expensive, because evaluation of new ingredients and their formulation is by long term feeding trials. The main objective of this program is to develop biomarkers to reduce the time and expense involved wit h feeding trials. Increased speed will al...

Tildelt: kr 9,4 mill.

Prosjektperiode: 2006-2008

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Improved Tumor Models by Functional Genomic Tissue Engineering

Cancer is not a single cell disease: tumors comprise two distinct but interdependent compartments,neoplastic tumor cells and an interposed supporting stroma (e.g. connective tissue, blood vessels). All tumors require stroma for nutritional support and was te product removal and a strong correlati...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2006-2008

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Development of male contraceptive through manipulation of the sperm specific protein CalphaS

This project is aimed at developing leads for male contraceptives on a collaborative basis between Spermatech AS (www.spermatech.com), the Institute of Basic Medical Sciences, UiO and the Department of Andrology, The National Hospital of Norway (Rikshospi talet). We have identified and characteri...

Tildelt: kr 5,2 mill.

Prosjektperiode: 2006-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Sak e-02/05 Internasjonalt samarbeid mot Nord Amerika Tri-lateral forum workshop on: Marine Fish Aquaculture"

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Tildelt: kr 79 999

Prosjektperiode: 2006-2006

Sted: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

When choice determines circumstances

New genetic methods allow parents to screen for certain undesirable traits and select away embryos with these traits. The same methods will, at least if they are developed, also allow positive selection. Parents could get the opportunity to select for tra its that they believed to be desirable. T...

Tildelt: kr 0,20 mill.

Prosjektperiode: 2005-2006

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

European Animal Disease Genomics Network of Excellence for Animal Health and Food Safety - EADGENE Delprosjekt 4: Mastitt hos storfe

Dette prosjektet representerer ett av fire prioriterte områder innenfor EU nettverket "European Animal Disease Genomics Network of Excellence for Animal Health and Food Safety" - EADGENE. Den endelige målsetningen er gjennom internasjonalt og nasjonalt sa marbeid å bidra til å identifisere gener,...

Tildelt: kr 0,40 mill.

Prosjektperiode: 2005-2009

Sted: Akershus

FUGE-Funksjonell genomforskn.i Norg

Development and Evaluation of Reporter Mice for Molecular Imaging

Regulation of gene expression is at the centre of our understanding of normal development as well as most, if not all types of diseases. The need to follow the temporal and spatial patterns of expression of individual genes in vivo is therefore obvious. T he research group of Professor Rune Blomh...

Tildelt: kr 2,1 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Improved immunity of aquacultured animals

Based on important disease models, this project concerns development of a technological knowledge platform for a future improved immunity to infectious pathogens in the major aquacultured species in Europe (Atlantic salmon, rainbow trout, sea bream, sea b ass, carp, mussel and oyster). Focus will...

Tildelt: kr 0,35 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Tools for Microbial Nucleic Acid Sample Preparation for Diagnostic and Genomic Analyses

Access to high quality nucleic acid is imperative to conduct any form of genetic analysis. Working with micro-organisms that are difficult to cultivate and/or are embedded in complex materials is a particular challenge. The market is seeking more sensitiv e, simplified, rapid and efficient method...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2005-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Development of immunostimulatory therapy disrupting the hyperactivated cAMP signalling pathway in HIV immunodeficiency

LAURAS is developing immunostimulatory drugs that will reverse the immunodeficiency in HIV and other immunodeficiencies. Such treatment is called for since the present antiretroviral treatment (HAART) does not offer cure for the disease, is associated wit h resistance and has significant side eff...

Tildelt: kr 4,7 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Data Integration Aand Modelling: On a New Design to enable Systems biology (DIAMONDS)

We will demonstrate the power of a Systems Biology approach to study the regulatory network structure of the most fundamental biological process in eukaryotes: the cell cycle. An integrative approach will be applied to build a basic model of the cell cycl e, in four different species including S....

Tildelt: kr 0,43 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Improved immunity of aquacultured animals

Tildelt: kr 0,15 mill.

Prosjektperiode: 2005-2007

Sted: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Tilleggsstøtte til EU prosjekt: Glutamate receptor interacting proteins as novel neuroprotective targets

Excitotoxicity contributes significantly to neuronal cell death in a number of neurological conditions including stroke, head trauma, and Huntington’s disease. The recent discovery of the proteins that anchor and interact with glutamate receptors opens fo r a new strategical approach to cytoprote...

Tildelt: kr 1,00 mill.

Prosjektperiode: 2005-2007

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Funksjonelle studier av genekspresjon in vivo ved inflammatoriske sykdommer

The Blomhoff group was deeply involved in the application of the FUGE platform on transgenic mice, and the organisation of the platform. The described project builds on the expertise offered by the FUGE platform. Hallmarks of inflammation include activa tion of gene expression through the trans...

Tildelt: kr 0,50 mill.

Prosjektperiode: 2005-2008

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Tilleggsstøtte for deltagelse i EU-prosjektet LIPGENE

The primary focus of LIPGENE is the interaction of nutrients and genotype in the metabolic syndrome. This disorder is associated with overweight and obesity and is characterized by dyslipidaemia, insulin resistance and hypertension. With access to a large prospective cohort followed biannually f...

Tildelt: kr 0,40 mill.

Prosjektperiode: 2005-2006

Sted: Vestland

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