0 antall prosjekter

FRIMED-Klinisk medisin og folkehelse

L-Ornithine and phenylacetate: A novel and effective therapy for hepatic encephalopathy

Background: The major therapeutic target for the treatment of hepatic encephalopathy is ammonia. Our extensive investigations in animal models and also in humans with cirrhosis support the view that the major organ removing ammonia in patients with cirrho sis is the muscle, converting ammonia to ...

Tildelt: kr 1,3 mill.

Prosjektperiode: 2007-2009

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Contact meeting for the Norwegian Biochemical Society

The annual meeting of the Norwegian Biochemical Society has a world-wide reputation as an excellent meeting place for scientists, both on the scientific and the social level. They have been a tremendous success and is arguably the one meeting in Norway wh ich has contributed the most to the conta...

Tildelt: kr 0,36 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRINAT-Matematikk og naturvitenskap

Study of entanglement and quantum information in condensed matter systems.

The quantum computer is a hypothetical computer that utilizes the superposition principle of quantum mechanics to perform certain computational tasks much faster than any classical computer can. Entanglement is one of the most curious phenomena in Nature, which involves the collapse of the quant...

Tildelt: kr 2,1 mill.

Prosjektperiode: 2007-2009

Sted: Trøndelag - Trööndelage

FRITEK-Teknologi

Sequences and Their Applications

Sequences have numerous uses in modern communication systems. They have found ingenious application to error-correcting codes, cryptography, and in particular to the design and analysis of stream ciphers, radar systems, Global Positioning Systems (GPS) and modern third generation mobile communi...

Tildelt: kr 4,6 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

EVITA-eVitenskap

Database Support for Computational Science Applications

The proposal is for a research project within the eVita program for the Norwegian ICT sector, investigating issues in data management in Grid systems. So far, Grid computing as gained some maturity with respect to the actual computation. However, the mana gement of data in Grid systems is still a...

Tildelt: kr 4,1 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Dynamics of synaptic transmission in the rod pathway of the retina

A considerable challenge in neuroscientific research is to explain processes at the systems level in terms of mechanisms at cellular and molecular levels. The retina serves as an ideal model system amenable to experimental approaches that directly aim to bridge this gap. With respect to the senso...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

FRIBIO-Biologi og biomedisin

The role of excitatory amino acid in Parkinson's disease

Parkinson's disease is characterised by death of dopamine containing neurons in the substantia nigra. Long term levo-dopa treatment has severe side effects and is potentially toxic for neurons. The need for alternative treatments in Parkinson's disease is urgent. To accomplish this, further rese...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular and cellular mechanisms of the hippocampal memory system studied by in vivo recording in behaving animals

A major challenge in neuroscience is to explain behaviour in terms of molecular, cellular and neuronal network mechanisms. We will study mechanisms of the medial temporal lobe memory system by in vivo recording of hippocampal single unit and neuronal netw ork activity (EEG) in freely mowing rats ...

Tildelt: kr 2,3 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

FRIBIO-Biologi og biomedisin

Vaccine development for HIV and influenza

Aim: Based on the vaccibody principle developed by us, we wish to generate novel vaccines for important infectious diseases such as HIV and influenza. Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However , for some important diseases such as HIV...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRITEK-Teknologi

High-level Formal Modeling and Analysis of Real-Time and Hybrid Systems

The functionality of many modern advanced computer systems -- such as, e.g., wireless sensor networks, the Internet and other kinds of networks, and control systems -- is crucially dependent on the amount of time that passes during/between events. Furthe rmore, such advanced and often critical s...

Tildelt: kr 4,6 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

The Tromsø Pain Study: Causes and consequences of individual differences in pain sensitivity

Human pain sensitivity is subject to very large inter-individual variation. It is known that pain sensitivity is heritable, but the genes involved are largely unknown. Hypersensitivity to pain may be an important risk factor in the development, maintenanc e and consequences of chronic pain. Reduc...

Tildelt: kr 3,7 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMED-Klinisk medisin og folkehelse

Tissue engineering in bone defects: Development of porous copolymer scaffolds stimulating stem cell growth and bone regeneration

For the repair of bone defects, tissue engineering would be to combine cells capable of osteogenic activity with an appropriate scaffold. Mesenchymal stem cells are multipotential cells that are capable of differentiating into different type of cells dep ending on culture condition. The selectio...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular responses to meningococcal meningitis

Meningococcal disease is a leading cause of meningitis and septicaemia worldwide. Among the serious consequences of meningitis are brain edema and disturbed neuronal excitability. These effects are often the direct cause of death. Despite the serious comp lications, the molecular basis for these ...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Statistical tools for studying genetic architecture

Advances in molecular biology have revealed that most phenotypes are controlled by highly complex and interactive gene networks. This complex genetic basis is, however, not reflected in the rather simple genotype-phenotype maps postulated in population an d quantitative genetics. These models are...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Rapid DNA-based prediction of mycotoxin levels in food and feed

The major mycotoxin producers in foods in Norway and Europe are members of the genera Aspergillus, Fusarium and Penicillium. Two major classes of mycotoxins produced by Fusarium spp. are trichothecenes and fumonisins. The biosynthetic pathways involve gen es organised in (Tri- and Fum-) gene clus...

Tildelt: kr 2,6 mill.

Prosjektperiode: 2007-2011

Sted: Akershus

BIONÆR-Bionæringsprogram

Technology and methods using high-density microarrays for detection of unknown genetic modifications in plants, fungi and bacteria

To ensure the safety of genetically modified organisms (GMOs) they are subjected to risk assessment prior to release into the environment and use in e.g. food production. Such known GMOs are considered to be as safe as conventional varieties. GMOs for whi ch publicly available descriptions are un...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2012

Sted: Akershus

FRIBIO-Biologi og biomedisin

A novel signal transduction pathway regulating cell separation processes in plants - the IDA/IDL network and their predicted partners.

Signaling mediated by small peptides is important in cell-to-cell communication. Few peptide ligands involved in cell signaling are known from plants and even less is known about the peptide-ligand-receptor pairs. A group of small putative peptide-ligands have recently been characterized by the ...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Competence-induced cell lysis in Streptococcus pneumoniae: Implications for horizontal gene transfer and virulence

Streptococcus pneumoniae have the ability to enter a transient phenotype termed competence for natural transformation, which enables the bacterial cells to take up free DNA from the surrounding environment. Recently, it was discovered that competent cells also aquire the ability to lyse neighbou...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2007-2010

Sted: Akershus

RENERGI-Fremtidens rene energisystemer

Hydrogen production from natural gas in high-temperature membrane reactors: Advanced catalysis from atoms to processes

The project deals with a development of a catalyst system in a high temperature hydrogen permeable membrane reactor, enabling production of hydrogen and CO2 simultaneously from natural gas. The active, stable and cheap catalysts will be developed by new c atalyst design through the combination of...

Tildelt: kr 3,9 mill.

Prosjektperiode: 2007-2012

Sted: Trøndelag - Trööndelage

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Automatic weed assessment for precision spraying in cereals

The load of herbicides on Norwegian cereals fields is unnecessarily high. The spraying represents an unnecessary cost for farmers, in Norway estimated to about 20 millions NOK yearly, and lots of herbicides superfluously spread to the environment. The mos t important reason for this excessive her...

Tildelt: kr 8,4 mill.

Prosjektperiode: 2007-2010

Sted: Akershus

BIONÆR-Bionæringsprogram

Preclinical diagnosis of prion disease

Transmissible spongiform encephalopathies (TSEs) are a threat to food safety and to human and animal health. Diagnosis of these diseases and early detection of the infective agent is vital for future spread and prevention of disease. The identification of candidate molecules as biomarkers of pre...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Stability and mobility of Shiga toxin-encoding bacteriophages in clinical and environmental strains of Escherichia coli O103

E. coli O103 belongs to a subset of serotypes of Shiga toxin-producing Escherichia coli (STEC) associated with severe human illnesses. Shiga toxin (Stx) production is essential but not sufficient for virulence in pathogenic STEC as factors involved in att achment, haemolysis and iron scavenging a...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

STAMCELLER-Stamcelleforskning

Impact of DNA base lesion repair for stem cell maintenance

DNA damage (mutations) are the fundamental cause of all forms of cancer and a number of different but integrated processes operate to prevent genetic changes from occurring. These include cell cycle regulation, DNA replication, transcription, DNA repair, regulation and sanitation of nucleotide po...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular control of differentiation of multipotent stem cells in simple marine animals

The maintenance of stem cells and the regulation of their differentiation are still poorly understood. Interstitial stem cells are easily accessible in the simple animal Hydra and give rise to different neuronal cell fates, gametes and gland cells. In con trast, no interstitial stem cells have be...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2013

Sted: Ukjent Fylke

SIP-NHD-Strategiske instituttprogram finansiert av NHD

New and improved remote sensing techniques for environmental monitoring

The proposed SIP will be divided into four main parts, EM Scattering properties, UAV technology, Environmental Informatics, and Applications. In the EM scattering properties part the main activity is improved understanding and modelling of the interaction of EM waves with the earth surface. This...

Tildelt: kr 10,8 mill.

Prosjektperiode: 2007-2009

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

The role of normal neighbouring keratinocytes and fibroblasts on clonal expansion of oral cancer (stem) cells

Recent studies, including ours, have shown that the invasive behaviour of cancer cells is not solely due to mechanisms intrinsic to the individual tumour cell. Genetic changes of individual cells in a specific tissue are not sufficient for invasive cancer to develop. Rather, there is a vivid cro...

Tildelt: kr 1,1 mill.

Prosjektperiode: 2007-2009

Sted: Vestland

FRIBIO-Biologi og biomedisin

Electrical signaling in thin dendrites and axons in the cortex

A major challenge in neuroscience is to understand the mechanisms of neuronal computation, much of which is carried out by electrical signals generated by ion channels in the cell membrane. Within the last decade, advances in patch-clamp and imaging techn iques have extended our knowledge of such...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

BIONÆR-Bionæringsprogram

Kartlegging av effekt av råstoff og produksjonsprosess på proteolytiske og lipolytiske endringer ved produksjon av langtidsmodnet spekeskin

Prosjektet, med kortnavn Enzymgris, har som hovedmål å kartlegge råstoffegenskaper i skinkeråstoff fra ulike svineraser ved ulike slaktealdre, for å bestemme hvilken rase og slaktealder som er best egnet til produksjon av norsk langtidsmodnet spekeskinke. Noe av det unike i prosjektet er det nøy...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2007-2013

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Novel nutritonal products for improved metabolic health.

The importance of nutrition for metabolic health has been the subject of a growing interest both from the scientific community and the public in recent years. Obesity and obesity-related disorders, often referred to as the metabolic syndrome, is a serious condition with the presence of a number ...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

SIP-LMD-SIP finansiert av Landbruksog matdepartementet

Phytophthora diseases in Rosaceae: Plant resistance and plant-pathogen interactions

Each year strawberry- and raspberry producers experience serious economical losses due to fungal or oomycete diseases. In this project we will address two such diseases, strawberry crown rot (Phytophthora cactorum) and raspberry root rot (Phytophthora fra gariae var. rubi). An efficient control m...

Tildelt: kr 7,3 mill.

Prosjektperiode: 2007-2011

Sted: Akershus