FRIMEDBIO-Fri prosj.st. med.,helse,biol

Base excision repair proteins in DNA repair and early steps of adaptive immunity

DNA is continuously damaged by cellular and environmental agents. Five main DNA repair pathways correct such lesions. These are important in cancer prevention, but surprisingly, also for adaptive immunity. Our research group concentrates on base excision repair (BER) and direct repair of damage....

Tildelt: kr 5,3 mill.

Prosjektperiode: 2011-2014

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanisms of mammalian DNA Repair

DNA repair prevents cancer and early aging and is essential for adaptive immunity. Our objective is to obtain detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair by human AlkB homologs. In addition, we will now expand our research into possible epi...

Tildelt: kr 5,9 mill.

Prosjektperiode: 2009-2013

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanism of mammalian DNA repair

DNA repair prevents cancer and early aging and is essential for the immune system. Our objective is to obtain a detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair. BER is a template-dependent multistep proc ess initiated by a DNA glycosylase. The U...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2008-2013

Sted: Trøndelag - Trööndelage

IS-BILAT-Mobilitet Norge-USA /Canada

Outbound mobility to City of Hope's Beckman Research Institute for two postdoctoral scholars who will do research on non-protein-coding RNA.

The proposal describes outbound mobility of two postdoctoral scholars and their families to City of Hope's Beckman Research Institute (Duarte, CA). The researchers are still partially employed by Interagon AS, where they have conducted their doctoral rese arch, but will now also be employed as po...

Tildelt: kr 0,23 mill.

Prosjektperiode: 2006-2007

Sted: Østfold

KREFTSATS-Særutlysning kreftmidler, historikk

GENOME MAINTENANCE MECHANISMS AND THEIR ROLE IN PREVENTING CANCER DEVELOPMENT

DNA repair genes represent a class of tumor suppressor genest hat have proven increasingly important in preventing cancer development in humans. This is not unexpected as DNA repair has been demonstrated to have a crucial role in maintaining genome stabil ity. DNA damage induced by cellular expos...

Tildelt: kr 6,6 mill.

Prosjektperiode: 2005-2007

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Molecular mechanisms of mammalian DNA repair

Mutations are the fundamental cause of all forms of cancer and a number of different, but integrated processes operate to prevent such genetic changes from occurring. DNA repair is of fundamental importance in limiting the occurrence of mutations. We will carry out comprehensive studies on the m...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2005-2009

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

FUGE- Midt-regionen Søknad om regional støtte (Tilleggsbev. til prosjekt 152324/150)

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Tildelt: kr 1,4 mill.

Prosjektperiode: 2003-2009

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Application for regional support - Functional Genomics, Central region of Norway (har tilleggsbev 158794)

1)Våre hovedprioriteringer er et forprosjekt for å analysere nødvendig behov og infrastruktur for lagring og bruk av data innen bioinformatikk. Denne satsingen kan betraktes som et forprosjekt for og analyse av ressursbehov både økonomisk og personalmessi g, kravspesifikasjonen innen dataløsning ...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2002-2008

Sted: Trøndelag - Trööndelage

MILJO-Miljøstøtte

Mechanistic and functional aspects of mammalian base excision repair

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Tildelt: kr 3,0 mill.

Prosjektperiode: 2002-2006

Sted: Trøndelag - Trööndelage