0 antall prosjekter

FUGE-Funksjonell genomforskn.i Norg

Genesis of B lymphomas studied by functional genomics

Background: Idiotypes (Id) are antigenic determinants in the variable regions of immunoglobulins (Ig). We have previously demonstrated that B lymphocytes partially degrade their endogenous Ig and present Id-peptides on their Major Histocompatibility Compl ex (MHC) class II molecules to CD4+ T cel...

Tildelt: kr 5,8 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Proteomic and bioinformatic studies of Mycobacterium tuberculosis

Tuberculosis (TB) is a major communicable disease linked to poverty with a substantial death toll of about 2 million cases annually. Research is needed to develop novel diagnostic tools, novel preventive measures such as vaccines and novel antibiotics. To do so it is of paramount importance to k...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2006-2010

Sted: Vestland

BIA-Brukerstyrt innovasjonsarena

Combination of chemotherapy, radiation and immunotherapy in patients with non-small cell lung cancer; improving cancer vaccine efficacy.

GemVax is in the international forefront in the development of peptide based active immunotherapy for treatment of cancer. GV1001 is a telomerase based cancer vaccine which in principle can act as a universal cancer vaccine. GV1001 is GemVax' lead com pound. The product has been developed in ...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

SIP-Strategiske instituttprogram

Planning and Organisation for improved Public Health (POPHEALTH)

Preventive public health (PPH) aims at reducing causes of health risks while strengthening the conditions contributing to improved better health. PPH implies efforts to improve health by influencing individual life styles as well as the general conditions of life facilitated by the physical envi...

Tildelt: kr 9,5 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Festulolium with improved forage quality and winter survival for Norwegian farming

"Development of Festulolium with improved forage quality and winter survival for Norwegian farming" is a five year research project aiming to assess forage quality and winter survival of Festulolium in Norway and develop germplasm for selection of cultiva rs with superior adaptation to Norwegian ...

Tildelt: kr 15,2 mill.

Prosjektperiode: 2006-2011

Sted: Akershus

BIA-Brukerstyrt innovasjonsarena

A novel antimicrobial agent for topical treatment of challenging infections caused by drug-resistant bacteria.

"Once life-saving medicines are increasingly having as little effect as a sugar pill. Since 1970, no new classes of antibacterials have been developed to combat infectious diseases. Microbial resistance to treatment could bring the world back to a pre-an tibiotic age." WHO Report 2000: Overcomi...

Tildelt: kr 8,8 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Optimising the antioxidant effect of Se in wheat

Selenium (Se) is a key antioxidant of major importance to health of living organisms. A series of stressors (e.g. radiation, chemicals) can induce free radicals in living tissues and subsequently negative effects such as oxidative stress and DNA/RNA damag e occur. The antioxidant effect of Se is ...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

BIA-Brukerstyrt innovasjonsarena

Development of mechanism based, novel anti-inflammatory compounds

Avexxin AS (founded in Trondheim march 2005) introduces a novel therapeutic approach for the treatment of chronic diseases including psoriasis based on more than a decade of research at Prof. Berit Johansen?s group at the Norwegian University of Science a nd Technology. The new compound interfere...

Tildelt: kr 7,8 mill.

Prosjektperiode: 2006-2009

Sted: Trøndelag - Trööndelage

BIA-Brukerstyrt innovasjonsarena

Høysensitiv nanopartikkelbasert homogen assayteknologi for analytter med høy molekylvekt

Det skal utvikles en høysensitiv nanopartikkelbasert homogen assayteknologi for konsentrasjonsbestemmelse av analyttermed høy molekylvekt. Slike immunoassays er raskere, og har mye større markedsvekst enn langsomme, kostbare separasjonsbaserte assays. De har tidligere blitt utviklet for analytter...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2006-2009

Sted: Østfold

FUGE-Funksjonell genomforskn.i Norg

The importance of post-translational glycosylation in the secretory pathway for expansion of the functional repertoire of gene products

Most proteins in animal and plant cells are glycosylated, a fact that must be taken into account for all aspects of protein studies, because the glycan portion often influences protein activity and cellular targeting, and more practically, protein purific ation, crystallization and structural det...

Tildelt: kr 1,6 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Entry of Nanoparticles into cells: Characterization of Nanoparticles as tools to study endocytic pathways..

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Tildelt: kr 2,7 mill.

Prosjektperiode: 2006-2010

Sted: Ukjent Fylke

BIA-Brukerstyrt innovasjonsarena

Utvikling og klinisk uttesting av et implantat til bruk på pasienter med ileostomi (utlagt tynntarm)

I FoU-prosjektet skal det utvikles og klinisk uttestes et implantat som skal gi pasienter med ileostomi forbedringer hva gjelder både medisinske komplikasjoner og livskvalitet. Et velfungerende stomiimplantat med et tømmesystem som også kan tillate posef rie perioder, vil representere en betydel...

Tildelt: kr 6,5 mill.

Prosjektperiode: 2006-2010

Sted: Oslo

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Reduced risk of Fusarium and mycotoxin contamination in Norwegian cereals by the development of a rapid screening system

Fusarium infection in cereals has become a problem world-wide. Species of Fusarium produce mycotoxins that leave the grains unsuitable for consumption. In the 2004 harvest, alarming levels of the mycotoxin deoxynivalenol (DON) was registered in grain lots of Norwegian grown wheat and oats. This ...

Tildelt: kr 11,7 mill.

Prosjektperiode: 2006-2010

Sted: Akershus

FRIBIO-Biologi og biomedisin

Mechanisms behind pathogen activation and evasion of Toll-like receptor signaling

Toll-like receptors (TLRs) are signaling receptors of the innate immune system, sensing a variety of bacterial and viral components. Our central hypothesis is that immune cell recognition of invading pathogens starts with an interaction between microbial structures and TLRs. The following immune ...

Tildelt: kr 2,4 mill.

Prosjektperiode: 2005-2011

Sted: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Endothelial cell differentiation - a key to future therapy of chronic inflammation and cancer

Much attention is focused on understanding the role of vascular endothelial cells in disease. In several fields of medicine, there is great interest in understanding the mechanisms that regulate the generation of new vessels and endothelial cell different iation, because the future ability to man...

Tildelt: kr 1,8 mill.

Prosjektperiode: 2005-2009

Sted: Oslo

NANOMAT-Nanoteknologi og nye materialer

Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces

Project: Characterization of nanotubular networks on cell adhesive micro- and nano-patterned surfaces Recently we have discovered that mammalian cells are connected by thin membrane tubes. These tubes with a diameter of 50 to 200 nm are referred to as tu nneling nanotubes (TNTs). They are a cont...

Tildelt: kr 3,2 mill.

Prosjektperiode: 2005-2010

Sted: Vestland

FRINAT-Matematikk og naturvitenskap

Antimicrobial peptides targeted against multiresistant Staphylococcus aureus with engineered proteolytic stability.

The rate of multidrug-resistant infections is rapidly rising. Cationic antibacterial peptides are both active against resistant pathogens and have low propensity for resistance development, but due to their unfavourable medicinal properties cationic antib acterial peptides have yet been a limited...

Tildelt: kr 3,3 mill.

Prosjektperiode: 2005-2010

Sted: Troms - Romsa - Tromssa

ELSA-Etiske,rettslige og samf.m. as

National moral landscapes: The Politics of Stemcells

Stemcells have occupied the centerstage of scientific, public and political awareness since its isolation in 1998. They produce golden hopes of finding future cures for a lot of diseases, but also provoke very heated and antagonistic public debates. It cr eates deep moral concers, involving the s...

Tildelt: kr 2,2 mill.

Prosjektperiode: 2005-2009

Sted: Vestland

YFF-Yngre, fremragende forskere

Molecular portraits of breast cancer: Translating genomics to the clinical practice

By using hierarchical clustering of global gene expression data, we were the first to identify five subtypes of breast tumors characterized by specific expression patterns. Our existing work has generated a rich and unique resource and knowledgebase from which to continue research. We will apply ...

Tildelt: kr 7,4 mill.

Prosjektperiode: 2005-2010

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Selection and characterization of novel cancer specific antibodies – utilization in diagnostic and therapeutic approaches

Objective: The main purpose is to identify and characterize novel breast cancer specific antibodies. Interesting candidates will be thoroughly characterized for their specificity. Fulfilling the specificity criteria their potential as diagnostic or progno stic markers will be investigated. Finall...

Tildelt: kr 4,0 mill.

Prosjektperiode: 2005-2010

Sted: Ukjent Fylke

GNBIO-Grunnleggende næringsrettet bioteknologi

Novel biologically active molecules through a combined application of bioinformatics and genetic engineering

The proposed research project is intended to further develop and test a unique drug discovery platform created at the NTNU/SINTEF (Norway) and the Institute of Biomedical Chemistry (Russia), which is composed of a powerful new bioinformatics tool and a te chnology for gene manipulation of antibio...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2005-2009

Sted: Trøndelag - Trööndelage

ELSA-Etiske,rettslige og samf.m. as

The moral status of human embryos with special regard to stem cell research and therapy

This is a multidisciplinary project with contributions from biology, medicine, philosophy and theology. The background for the project are the developments going on within the fields of basic and clinical research on and clinical use of human stem cells. These new biotechnological possibilities h...

Tildelt: kr 2,7 mill.

Prosjektperiode: 2005-2010

Sted: Oslo

FUGE-Funksjonell genomforskn.i Norg

Regulation of intracellular traffic by PI3P-binding proteins - a functional and ultrastructrural study

Many important cellular processes such as intracellular transport, signaling through growth hormone receptors, cell motility and apoptosis are regulated directly or indirectly by phosphatidylinositol (PI)-3-kinases. These kinases have different reaction products, one of these being PI-3-phosphat...

Tildelt: kr 7,6 mill.

Prosjektperiode: 2005-2009

Sted: Ukjent Fylke

STORFORSK-Store forskerinitierte prosjekter

Adipose Stem Cells: Molecular Basis of Pluripotency

Stem cells reside in many adult tissues and are responsible for maintaining tissue homeostasis. Adipose tissue-derived mesenchymal stem cells (ASCs) display sufficient plasticity to differentiate into cell types outside their predicted developmental linea ge. This might create opportunities for a...

Tildelt: kr 18,5 mill.

Prosjektperiode: 2005-2011

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Enzyme evolution and advanced strain engineering in biorprocess development

...

Tildelt: kr 8,2 mill.

Prosjektperiode: 2005-2011

Sted: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Tools for Microbial Nucleic Acid Sample Preparation for Diagnostic and Genomic Analyses

Access to high quality nucleic acid is imperative to conduct any form of genetic analysis. Working with micro-organisms that are difficult to cultivate and/or are embedded in complex materials is a particular challenge. The market is seeking more sensitiv e, simplified, rapid and efficient method...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2005-2009

Sted: Oslo

KREFTSATS-Særutlysning kreftmidler, historikk

MOLECULAR AND BIOLOGICAL STUDIES OF CANCER METASTASIS

Metastasis, cancer spread to other organs, is the principle cause of death of cancer patients. Early detection of metastatic tumor cells, development of new treatment strategies and knowledge about how to prevent cancer metastasis are some of the most cha llenging tasks in cancer research. Our pr...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2005-2009

Sted: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Characterization and exploration of microbial enzymes for processing of chitin, chitosan and peptidoglycan

The availability of an increasing number of microbial genomes, including the genome of the highly versatile white-rot basidiomycete Phanerochaete chrysosporium, offers unique possibilities to study and explore enzymes with potential biotechnological appli cations. In the present project, we will ...

Tildelt: kr 5,4 mill.

Prosjektperiode: 2005-2010

Sted: Akershus

YFF-Yngre, fremragende forskere

GENOMIC PLASTICITY

Directly turning a differentiated cell into a pluripotent cell would be beneficial for producing isogenic replacement cells. It would also present societal benefits by eliminating the use of cells of embryonic or fetal origin. Altering cell fate involves a reprogramming of nuclear function. We ha...

Tildelt: kr 7,0 mill.

Prosjektperiode: 2005-2010

Sted: Oslo

KREFTSATS-Særutlysning kreftmidler, historikk

Developmental biology of solid tumours may pave the way for advanced medicine

We study three human cancer diseases, colorectal cancer (CRC), testicular germ cell tumour (TGCT), and malignant peripheral nerve sheath tumour (MPNST), originating from different types of stem cells. All three diseases develop through morphologically def ined stages, and the stepwise molecular b...

Tildelt: kr 6,6 mill.

Prosjektperiode: 2004-2009

Sted: Oslo