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Dato fra ny til gammel

STAMCELLER-Stamcelleforskning

The AlkB family of demethylases; putative roles in embryonic stem cell identity and epigenetic reprogramming of the germ line.

This project is initiated primarily based upon the intriguing phenotype and breeding pattern of Alkbh (AlkB homologs) targeted mice. Targeting of mouse Alkbh's (8 in total) cause various degree of sex-ratio distortion and developmental abnormalities incl uding asymmetric left-right eye developme...

Tildelt: kr 6,0 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

STAMCELLER-Stamcelleforskning

Controlling oncogenic transformation of mesenchymal stem cells by targeted epigenetic intervention

Spontaneous oncogenic transformation of mesenchymal stem cells (MSCs) is a risk factor when expanding stem cells in culture for therapeutic intervention. Transformed MSCs devide indefinitely and loose their ability to differentiate, arguing for epigenetic alterations of several classes of genes,...

Tildelt: kr 6,2 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

STAMCELLER-Stamcelleforskning

Principles of stem cell pathway heterogeneity in tumor sub-populations

There is an ongoing debate on heterogeneity of stem cell parameters in tumor cells and the existence of tumor stem cells. The enclosed project proposal uses cell cycle parameters and stem cell pathways to analyze and determine mechanisms for creating and maintaining cell heterogeneity in tumors....

Tildelt: kr 3,0 mill.

Prosjektperiode: 2009-2012

Sted: Oslo

STAMCELLER-Stamcelleforskning

Tissue engineering of hyaline cartilage

Cartilage injuries are frequent and lead to pain and disability. Unfortunately, articular cartilage shows a limited capacity for selfhealing and often goes on to osteoarthritis. Several surgical techniques have been developed to fill the cartilage defects , but so far none of them have been able ...

Tildelt: kr 7,7 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Nasjonalt stamcelleforskningssenter i Helse Sør-Øst RHF - se også prosjektnr 230000 hvor midler for ny periode ligger.

Nasjonalt senter for stamcelleforskning ble etablert i 2008 ved Oslo universitetssykehus (Rikshospitalet) etter et direktiv fra Helsedepartementet og midler administrert av Norges Forskningsråd. Senterets primærhensikter har vært å øke tempoet i norsk stamcelleforskning, etablere en platform ...

Tildelt: kr 34,3 mill.

Prosjektperiode: 2008-2019

Sted: Innlandet

STAMCELLER-Stamcelleforskning

Factors predicting graft-versus host disease after allogeneic hematopoietic stem cell transplantation.

Allogeneic stem cell transplantation (ASCTx) represents the most commonly applied therapeutic use of stem cells from born individuals. The mortality and complication rate of ASCT is high, often preventing its use in less severe conditions than cancer. Th e aim of this project is to generate a be...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

STAMCELLER-Stamcelleforskning

Impact of DNA base lesion repair for stem cell maintenance

DNA damage (mutations) are the fundamental cause of all forms of cancer and a number of different but integrated processes operate to prevent genetic changes from occurring. These include cell cycle regulation, DNA replication, transcription, DNA repair, regulation and sanitation of nucleotide po...

Tildelt: kr 5,0 mill.

Prosjektperiode: 2007-2010

Sted: Oslo

STAMCELLER-Stamcelleforskning

Tissue engineering in bone defects: Development of porous copolymer scaffolds stimulating stem cell growth and bone regeneration

For repair of bone defects, tissue engineering would be to combine cells capable of osteogenic activity with an appropriate scaffold. Mesenchymal stem cells are multipotential cells that are capable of differentiating into different type of cells dependin g on culture condition. The selection of ...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

STAMCELLER-Stamcelleforskning

Genome plasticity of somatic stem cells

Chromatin organization in stem cells arises from distinct combinations of epigenetic marks resulting in genomic plasticity. Mesenchymal stem cells (MSCs) have received intense attention due to their perceived potential use in regenerative medicine. Nothin g is known, however, on epigenetic marks ...

Tildelt: kr 4,9 mill.

Prosjektperiode: 2007-2011

Sted: Oslo

STAMCELLER-Stamcelleforskning

Signaling in neural stem cells: implications for regenerative medicine and tumor biology

Stem cell biology is one of the most closely followed developments in biomedicine today. Stem cells may provide the foundation for rational regenerative therapeutics with far-reaching implications in the health sector, but give also new alleys in the unde rstanding of tumor biology. The central ...

Tildelt: kr 12,4 mill.

Prosjektperiode: 2007-2012

Sted: Oslo

STAMCELLER-Stamcelleforskning

Cancer and Mesenchymal Stem Cells

Mesencymal stem cells (MSCs) isolated from the human bone marrow, have been suggested, based on their differentiation potential, to be used in tissue regeneration and repair strategies. While these cells may have a considerable therapeutic potential, it i s also possible that they may have unwant...

Tildelt: kr 3,5 mill.

Prosjektperiode: 2007-2010

Sted: Vestland

STAMCELLER-Stamcelleforskning

The role of HGF and other multiple myeloma cell products in osteoblastogensis from bone marrow stem cells.

Multiple myeloma, which is the second most frequent haematological cancer, is du to malignant transformation of antibody producing plasma cells. The tumour cells are found in the bone marrow, and severe bone degradation is characteristic for the disease. The presence of the malignant plasma cell ...

Tildelt: kr 2,5 mill.

Prosjektperiode: 2007-2011

Sted: Trøndelag - Trööndelage

STAMCELLER-Stamcelleforskning

EuroSTELLS Project: Translational Stem Cell Research: From Basic Biology to Regenerative Medicine

This project involves the joined forces of 13 research groups from 6 countries with common interests and complementary competence in developmental biology, stem cell biology and regenerative medicine and cancer biology. The consortium aims at elucidating the mechanisms that control self-renewal a...

Tildelt: kr 3,0 mill.

Prosjektperiode: 2005-2009

Sted: Oslo

STAMCELLER-Stamcelleforskning

Genome plasticity of somatic stem cells

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Tildelt: kr 1,5 mill.

Prosjektperiode: 2004-2006

Sted: Oslo

STAMCELLER-Stamcelleforskning

National network for stem cell research

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Tildelt: kr 20,5 mill.

Prosjektperiode: 2004-2006

Sted: Oslo

STAMCELLER-Stamcelleforskning

Allogeneic stem cell transplantation, mechanisms of graft adaptation and role in treatment of malignancies

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Tildelt: kr 3,0 mill.

Prosjektperiode: 2004-2006

Sted: Oslo

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