UoH-sektor

Instituttsektor

Offentlig sektor

Utlandet

Helseforetak

Øvrige

Næringsliv

Portefølje Naturvitenskap og teknologi ikon

Forskningssystemet

Portefølje Humaniora og samfunnsvitenskap ikon

Banebrytende forskning

Portefølje Samisk ikon

Samisk samfunn og kultur

Portefølje Demokrati, styring og fornyelse ikon

Demokrati og global utvikling

Portefølje Velferd, kultur og samfunn ikon

Velferd og utdanning

Portefølje Helse ikon

Helse

Portefølje Klima- og polarforskning ikon

Klima og miljø

Portefølje Landbasert mat, miljø og bioressurser ikon

Mat og bioressurser

Portefølje Energi, transport og lavutslipp ikon

Energi og transport

Portefølje Muliggjørende teknologier ikon

Muliggjørende teknologier

Portefølje Industri og tjenestenæringer ikon

Innovasjon

LTP2 Klima, miljø og miljøvennlig energi ikon

Klima, miljø og energi

LTP2 Samfunnssikkerhet og samhørighet ikon

Samfunnstryggleik og beredskap

LTP2 Fornyelse i offentlig sektor ikon

Velferdstjenester

Forsidebilde

Marin ikon

Petroleum og mineraler

LTP Hav ikon

Hav og kyst

LTP2 Muliggjørende og industrielle teknologier ikon

Mogleggjerande industrielle teknologiar

Tillit og fellesskap

LTP2 Utvikle fagmiljøer av fremragende kvalitet

Høg kvalitet og tilgjengeleg

LTP2 Styrket konkurransekraft og innovasjonsevne ikon

Sterkare konkurransekraft og innovasjonsevne

LTP3 Helse

Et innovativt næringsliv ikon

Styrket konkurransekraft og innovasjonsevne

Portefolje Petroleum Ikon

Portefølje Hav ikon

Portefølje Utdanning og kompetanse ikon

Portefølje Global utvikling og internasjonale relasjoner ikon

Portefølje Livsvitenskap ikon

Forsidebilde optimalisert

project-bank-technical

Muliggjørende teknologier bakgrunn

Marin bakgrunnsbilde

Statistikk

Prosjektbanken presenterer statistikk og informasjon om prosjekter med finansiering fra Forskningsrådet fra 2004. Statistikken er fordelt på blant annet tema, år, geografi og organisasjon. Prosjektbanken gir også detaljert informasjon om de enkelte prosjektene.

...eller se sammendrag og annen informasjon om prosjektene i utvalget ditt

Alle porteføljestyrer

En god beskrivelse av denne siden for søkemotoroptimalisering

Forside

Hvordan tildelingene fordeler seg på institusjoner, fylker, fagområder o.l....

Her er noen eksempler på søk du kan gjøre i Prosjektbanken

Alle langtidsplanmål

Veiledning: Hvordan bruke Prosjektbanken.no

Om Fritekstsøk

Ingen populærvitenskapelig framstilling tilgjengelig


Prosjektet med prosjektnummer {{project number}} ble ikke funnet

Teknisk beskrivelse

Oisann, her gikk noe galt. Kan du prøve å laste siden på nytt?  Dersom feilen vedvarer, vennligst kontakt oss.         

Se statistikk relatert til dette langtidsplanmålet

Se prosjekter relatert til dette langtidsplanmålet

knyttet til dette LTP-målet har blitt tildelt penger

har blitt tildelt til prosjekter knyttet til dette LTP-målet

har blitt tildelt til prosjekter knyttet til denne porteføljen

knyttet til denne porteføljen har blitt tildelt penger

Om Prosjektbanken

2013

2014

2015

2016

2017

2018

Nærings- og fiskerid

Fiskeri- og kystdepa

Landbruks- og fiskerifag

Vestland

LTP3 Styrket konkurransekraft og innovasjonsevne

LTP3 Et kunnskapsintensivt næringsliv i hele landet

LTP3 Grunnbevilgninger og institusjonell støtte

LTP3 Hav og kyst

LTP3 Marine bioressurser og havforvaltning

LTP3 Klima, miljø og energi

LTP3 Klima, polar og miljø

LTP3 Muliggjørende og industrielle teknologier

LTP3 Nano-, bioteknologi og teknologikonvergens

Portefølje Banebrytende forskning

Portefølje Forskningssystemet

Portefølje Mat og bioressurser

Portefølje Muliggjørende teknologier

Infrastruktur og institusjonelle tiltak

Institusjonsforankret strategisk prosjekt (t.o.m. 2018)

Marin

Politikk- og forvaltningsområder

Bransjer og næringer

Naturmangfold og miljø

Anvendt forskning

Bioteknologi

Grunnforskning

Algebraic Theory of Information Quantities

Information theory is a discipline at the intersection of statistics, engineering and computer science. As the study of information quantities, such as compression or communication capacities, information content or measures of statistical dependency, it is one of the theoretical underpinnings of data science.

Computational problems in information theory are highly non-linear. The goal of this project is to transfer state-of-the-art methods of computational non-linear algebra to information theory, to study the inherent algebraic complexity of information-theoretical problems and to provide tools for solving them in practice. The algebraic point of view has proven to be fruitful in seemingly unrelated areas, as witnessed by a surge of recent work in algebraic statistics, in particular on likelihood geometry. However, maximizing the likelihood function is the same as minimizing relative entropy — a specific information quantity. Hence, this project also aims at generalizing the techniques developed in likelihood geometry.

One focus is on the practical computation of information quantities using numerical and differential algebraic geometry. Such quantities are defined via non-linear optimization problems and we aim to pinpoint the algebraic complexity of these problems in instances of general interest, such as common information measures. The final objective is finding fundamental laws and limits of data science imposed by non-linear inequalities constraining the entropic region. These inequalities provide, by duality, universal bounds for many of the optimization problems studied in information theory.

WHeelchair Activity Monitoring project (WHAM)

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

EOSC Beyond: advancing innovation and collaboration for research

EOSC Beyond overall objective is to advance Open Science and innovation in research in the context of the European Open Science Cloud (EOSC) by providing new EOSC Core capabilities allowing scientific applications to find, compose and access multiple Open Science resources and offer them as integrated capabilities to researchers. To do so, EOSC Beyond supports a new concept of EOSC: a federated and integrated network of Nodes operated at different levels, national, regional, international and thematic, to serve the specific scientific missions of their stakeholders. Further specific objectives of the project are to accelerate ‘time to product’ of new scientific applications with software adapters, enable Open Science with machine composability and dynamic deployment of shared resources, support innovation in EOSC with a testing and integration environment, and align the EOSC Core architecture and specifications to integrate with European dataspaces. The project extends the state of the art of the EOSC Core and adopts a co-design methodology, including requirements elicitation, software development and validation in collaboration with different use cases from EOSC national and regional initiatives (e-Infra CZ, Czechia, NFDI, Germany, and NI4OS, South East Europe region), thematic research infrastructures from Social Sciences and Humanities (CESSDA), Life Sciences (CNB-CSIC and Instruct-ERIC), Environmental Science (ENES and LifeWatch), and Health and Food (METROFood-RI). EOSC Beyond builds on the capacities of prospective EOSC Nodes and partners with multi-annual experience in developing solutions for large-scale federated digital infrastructures and aligns with the technical architecture and requirements of data spaces from different business sectors. Ultimately, EOSC Beyond supports Open Science in modern, data-intensive, and multidisciplinary research, facilitating resource discovery, access, and reuse across scientific communities, organisations, and countries.


Harmonization of Advanced Materials Ecosystems serving strategic Innovation Markets to pave the way to a Digital Materials & Product Passport

The overarching objective of DigiPass is to enhance the digital maturity of the European communities that develop materials and intermediate products. The project will develop recommendations and clear routes toward digitalized circular business models. The overarching key result of DigiPass is to create a sustainable platform which includes support for Digital Materials & Product Passport and for collaborative innovation-by-design processes in a circular economy served by advanced materials. A business model for operating such a platform completes the overarching objective.
DigiPass is harmonizing and synergizing collected materials data sources and digital infrastructures. This will enable interoperability of data exchange, and standardization of advanced materials knowledge representation at all maturity levels. Accelerating the design, development, and production of advanced, safe, and sustainable chemicals and materials, as they are necessary for innovative products, calls for a collaborative approach involving different stakeholders to support durability, repair and overhaul, reuse, and recyclability of products. DigiPass project impacts all materials development communities over the whole circular value chain. 


Enhanced X(cross)-disciplinary Community-driven Imaging Technologies for Earth and Environmental material research

The EXCITE² Network is revolutionizing Earth and environmental material science research by consolidating a critical mass of 18 research facilities in 12 European and associated partner countries into a unified infrastructure and providing transnational access to advanced imaging technologies. This enables scientists to decipher complex processes within Earth materials at scales from nanometres to hundreds of centimetres, gaining unparalleled insight into the chemical and physical processes that govern, among others, environmental toxicity and its impact on human health, critical metal extraction for renewable energies, and the utilisation of Earth materials as long-term storage for climate-altering gases. The consortium fosters knowledge-sharing and talent attraction, bolstering the problem-solving capacity of the European Research Area. Moreover, EXCITE² is driving interdisciplinary collaboration and cross-fertilisation across academic institutions, scientific disciplines, and industry, propelling Europe towards a sustainable future. The initiative offers dedicated training programmes to a new generation of researchers within the European open science landscape, paired with access to world-class imaging facilities and expertise for problem-solving research and innovation. EXCITE² is introducing innovative service developments, such as artificial intelligence and leading-edge imaging experiments, to increase the user's problem-solving capacity. In addition, the consortium is implementing customised project valorisation strategies to maximize the impact of research outcomes in academia, society, and the economy. Citizen science projects allow the public to participate directly within the EXCITE² Network, contributing to solving EU challenges. As such, EXCITE² is paving the way towards a sustainable future, driving scientific excellence, and creating positive societal impact.

Engineering carbon quantum dots for zinc ion hybrid capacitors

Zinc ion hybrid capacitors (ZIHCs) integrate two energy storage mechanisms of battery-type electrode and capacitive electrode, bearing the advantages in energy density, power density, and safety. Until now, the cycle retention rate of ZIHC's capacity reported is still not more than 80%, restricting its development and commercial application severely. Focusing on the issue, the project aims at overcoming the limitation of traditional electrode materials and re-defining the designing concept to construct Carbon Quantum Dots (C-QDs) for ZIHCs. Advanced methods will be used to harvest carbon quantum dots from coal tar pitch (a sort of industrial solid castoff). The bulk sp2-carbon network, innumerable edge sites, profuse surface functional groups, and regular size ensures that as-synthesis C-QDs have high electrical conductivity, sufficient ion transport channels and rich adsorption sites. Moreover, the new concept of dynamic evolution is introduced for insight into the structure and interface failure of ZIHC's electrode. The interface-reconstruction mechanism and the attenuation model of capacity will be established for the first time. Further, the methods to strengthen structures of C-QD electrode will be developed based on a trade-off strategy. The ultimate goal is to improve the energy storage efficiency of ZIHCs by 20% and to increase their cycle performance more than 95% unprecedentedly. This research will develop long-running high performance ZIHCs, for contributing European energy storage industry. The ER will achieve abundant research experience and scientific skills from the project and the capability to launch her own research group in future.

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Aqua Research Infrastructure Services for the health and protection of our unique, oceans, seas and freshwater ecosystems

AQUARIUS will provide a highly comprehensive suite of integrated research infrastructures appropriate to addressing significant challenges for the long-term sustainability of our unique oceans, seas and freshwater ecosystems. For the first time, diverse research infrastructures will be combined to facilitate the work of researchers and key stakeholders focused on challenges and opportunities for both marine and freshwater systems. An impressive range of 57 research infrastructure services will be made available to include research vessels, mobile marine observation platforms, aircraft,  drones, satellite, sensors, fixed freshwater and marine observatories and test sites, experimental facilities, and sophisticated data infrastructures. AQUARIUS will support the development phase of the EU Mission to Restore our Ocean and waters by 2030, the Sustainable Blue Economy Partnership, the European Green Deal, and international climate initiatives. It will also be an essential component in achieving the European Digital Twin of the Ocean and the UN Decade for Ocean Sciences. The needs of researchers will be met through a robust and transparent system of transnational access funding Calls, facilitated by centralised user-friendly access portal. The Call programme will be informed through stakeholder engagement and brokerage events. Projects to be selected for Access must convincingly integrate multiple infrastructures and contribute to the core policy objectives of Mission Ocean, that is, to protect and restore marine and freshwater ecosystems and biodiversity; to prevent and eliminate pollution of our oceans, seas and waters; and to ensure a sustainable, carbon-neutral and circular blue economy. A thematic and geographic focus will be the hallmark of the proposed transnational Calls, aligning with the Lighthouse Regions, that is, the Baltic and the North Sea Basins, Black Sea, Atlantic/Arctic, and Mediterranean Sea along with their associated rivers.

EOSC-ENTRUST: A European Network of TRUSTed research environments

The mission of EOSC-ENTRUST is to create a European network of trusted research environments for sensitive data and to drive European interoperability by joint development of a common blueprint for federated data access and analysis. 
Countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policy-driven analysis of sensitive datasets such as people's health and socio-economic status, the habitats of vulnerable species and geo-spatial locations of protected sites. There are now a large number of such secure environments in operation - linked to national centres, individual organisations or specific research communities. This fragmented landscape poses challenges for both users and providers: researchers are faced with a large number of different systems and access procedures; providers need to manage federated access across multiple, potentially incompatible, technology and governance frameworks.
EOSC-ENTRUST brings together providers of operational Trusted Research Environments from 15 European countries with a shared goal to implement, validate and promote their capabilities through a common European framework using shared standards and common legal, operational and technical language. This blueprint for interoperability is anchored in the EOSC Interoperability Framework spanning the four dimensions of Legal, Organisational, Technical and Semantic interoperability. EOSC-ENTRUST has identified four driver projects covering Genomics, Clinical trials, Social science, and public-private partnerships to benchmark capabilities, inform blueprint design and demonstrate secure  data analysis using federated workflows.
Targeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a long-term operational TRE framework within the European Open Science Cloud.


Providing research infrastructure services to support Next Generation EU

This four-year project will harness outputs from key social science RIs in Europe and other reliable sources to support the aims of the ‘Next Generation EU’ programme and to inform EU youth policy. Virtual access will be provided to the outputs through special installations (portals) developed during the project. The core of the proposal is a set of existing research ‘services’, which will be re-purposed and customised to focus directly on the five themes: Make it Green; Make it Digital; Make it Healthy; Make it Strong; and Make it Equal. 

For each area, the consortium will work collaboratively to produce seven sets of resources:

i)	A searchable inventory of relevant variables drawn from multiple cross-national datasets; 

ii)	Analytical summaries, suitable for policy makers and analysts new to the field, as well as interactive resources available through the project portal;

iii)	Harmonised and merged extracts from these datasets that reduce the burden on analysts and increase sample sizes;

iv)	New data collected through the ESS’s established CRONOS web panel infrastructure. Eleven countries will field five waves of the panel, each one dedicated to a NextGenEU theme. Free and rapid access to the data will be available through the CRONOS portal alongside analytical summaries;

v)	In-person and virtual deliberative forums with young people (aged 18-34) in four countries covering the five Next Generation EU’ themes;

vi)	An educational tool (E-NextGen) channelling our data for use in classrooms and by the general public;

vii)	Comprehensive training materials related to all project outputs.


Autonome skip, intensjoner og situasjonsforståelse

Midlene fra MAROFF-2-Maritim virksomhet og offsh-2 fordelt på år

Midlene fra MAROFF-2-Maritim virksomhet og offsh-2 fordelt på fylker

Midlene fra MAROFF-2-Maritim virksomhet og offsh-2 fordelt på fagområde

Associate professor

Med basis i verdensledende kompetanse innen sensorfusjon og maritime antikollisjonssystemer fra Autosea-prosjektet (2015-2019), forsker Autosit-prosjektet på situasjonsforståelse for autonome overflatefarkoster. I det meste av forskningslitteraturen forstås situasjonsforståelse som forståelsen en menneskelig operator har av en operasjon som han eller hun har ansvar for. Det er imidlertid nødvendig at de autonome skipene i seg selv også er i besittelse av situasjonsforståelse, for at de skal kunne interagere med annen båttrafikk uten ulykker. Det er spesielt viktig at autonome skip i samme grad som en mennskelig båtfører har forståelse av hvilke intensjoner andre skip kan tenkes å ha. Denne forståelsen kan dannes med basis i ulike typer informasjonskilder. Historiske data for hvordan skip i ulike situasjoner pleier å oppføre seg kan brukes til å prediktere framtidig oppførsel. Det finnes systemer for informasjonsoverføring som AIS-systemet. Sensorer som kameraer og lidarer har høyere oppløsning både i tid og rom enn tradisjonelle radarer og kan si mye om et skips oppførsel og manøvreringsmuligheter. Autosit-prosjektet vil utvikle pålitelige og effektive algorimer for å fusjonere slike informasjonskilder inn i et helhetlig verdensbilde for det autonome skipet. 

I løpet av 2021 har arbeidet i Autosit-prosjektet fokusert på tre temaer: Langtidsprediksjon av skipsbevegelse via AIS-data, Fusion av radar- og AIS-data, og deteksjon av skipsdeler i kameradata. Innen langtidsprediksjon har vi spesielt studert systematiske teknikker som partikkelfiltere som kan gi en meningsfull representasjon av våre forventninger til framtidig bevegelse gjennom en sannsynlighesfordeling. Innen radar-AIS-fusjon har vi utviklet metoder som kombinerer styrkene til tradisjonelle målfølgingsmetoder med innsikter om hvordan AIS fundamentalt skiller seg fra radar.

Autonomous surface vehicles (ASV’s) need to be in possession of situational awareness in order to interact safely with other vessels, whether manned or unmanned. Building on cutting edge research in sensor fusion and collision avoidance, the Autosit project will deliver algorithms for situational awareness that enable ASV’s to guess and predict the intentions of other vehicles. These algorithms include long-term vessel prediction based on machine learning, fusion of radar and data from the automatic identification system (AIS), and pose estimation using cameras.

Autonomous ships, intentions and situational awareness

Dette prosjektet ble etablert for å få dypere kunnskap om hvordan næringsstoffer og giftstoffer endrer epigenetisk DNA-metyleringsmønstre hos fisk. Prosjektet har vært delt inn i fire arbeidspakker (WP):
 
WP1: I WP1 undersøkte vi hvordan arakidonsyre (ARA) i foreldrenes fôr påvirket avkommet (F1) gjennom epigenetiske endringer. Ved å bruke sebrafisk, fant vi ut at diettene forandret foreldres metabolisme, og påvirket genuttrykk og DNA-metylering i begge generasjoner. Hos foreldrene endret ikke fôret kroppsvekten, men endret den metabolske profilen av lipider. Sekvensering av barnas lever viste at avkommet ble påvirket både når det gjaldt DNA-metylering og genuttrykksprofiler. Effekten på genuttrykk var svakere hos foreldrene enn hos avkom. Genene med endret DNA metyleringsmønstre viste seg å være i de samme metabolske signalveier som var endret i foreldrenes metabolisme, noe som kan forklares ved at foreldrenes diett påvirker avkommet via epigenetisk programmering på tidlig livsstadier via DNA metylering av gametens DNA eller via næringsstoffinnholdet i plommemassen. Ph.d.-stipendiaten forsvarte avhandlingen og oppnådde doktorgrad i mars 2018.
 
WP2: Fokuset her var rettet mot epigenetisk regulering via 1C næringsstoffene (folat, vitamin B12, vitamin B6, cholin og metionin). Vi brukte sebrafisk som modell og studerte kjønnsmoden F1 fra foreldre som hadde fått lite 1C i kosten. Avkommet hadde en blek rød lever som skyltes høyere nivå av lipid i levercellene. Videre viste RNA-sekvensering endringer i steroid- og mitokondrie signalveier. DNA-metylering viste seg å være svært følsom for foreldrenes 1C næringsnivå, spesielt for genenes promotorregioner. Av 2869 forskjellig metylerte CpG?er som var påvirket epigenetisk av foreldrenes 1C nivå, hadde genet ppp2r2ba sterk hypometylering i 20 CpG-steder i alle replikatene. Dette genet regulerer cellevekst og celledeling. Mutasjoner i dette genet har vært knyttet til ødeleggelser i sentralnervesystemet. Det er mulig at forskjellene i DNA-metylering ble etablert tidlig i utviklingen, og disse kan ha regulatoriske effekter i andre vev.
Ved å bruke laks inkluderte vi tre forskjellige nivåer av 1C næringsstoffer, og genene i steroid signalveiene ble regulert spesifikt etter nivået i fôret. Fra de samme fiskene har vi fått renset DNA og metyleringsprofilen er sekvensert. Vi er nå i ferd med å analysere DNA-metyleringsmønsteret ved å tilpasse vår bioinformatiske metode til laksegenomet.

WP3: Målet med WP3 var å identifisere forskjeller i DNA metyleringsmønsteret i spytt fra spebarn og korrelere det med mødrenes Hg-status og sjømattinntak, samt å studere effekten av MeHg og umettede fettsyrer i sebrafisk. Dessverre kom vi ikke i mål med første del av prosjektet pga. at DNA isolert fra spyttprøvene var delvis degradert.  En studie med bruk av sebrafisk ble utført for å belyse transgenerasjonelle effekter av MeHg på DNA-metylering i F1 og F2-embryoer.

WP4: Målet med WP4 var å bestemme mulige endringer av epigenetiske mønstre forårsaket av miljøgifter påvist i sjømat ved å bruke sebrafisk og laks som modell. Resultatene viser at både genuttrykksmønsteret og epigenomet hos fisk kan påvirkes av disse miljøgiftene. For sebrafisk har vi funnet at bisfenol A (BPA), som blant annet finnes i matembalasje, påvirker larvenes svømmeaktivitet og kan påvirke DNA metylering. Spesielt har vi observert at protocadheriner er epigenetisk sensitive for BPA eksponering. Protocadheriner er viktige for nervecellers vekst og differensiering. BPA eksponering påvirket videre fosfatidylinositol, VEGF og MAPK signalveier. I tillegg har vi testet flere andre giftstoffer som 1,2-bis(2,4,6-tribromofenoksy)etan (BTBPE), klorpyrifos (CPF) og tris(2,3-dibromopropyl) fosfat (TDBPP) for effekter på DNA metylering og genekspresjon i sebrafisk. Mens CPF påvirket hedgehog systemet og gener knyttet til oocytt-meiose, hadde TDBPP effekter på signalveier knyttet til kardiomyocytter. Oppfølgende studier har vist at noen av disse miljøgiftene påvirker mekanismer knyttet til DNA metylering også i leverceller fra laks.

Sammen viser disse resultatene at epigenetisk regulering i fisk er svært følsom for både næringsstoffnivå og miljøgifter.

Epigenetics is the changes in phenotype due to processes arising independent of DNA sequence. This project will establish new knowledge on how nutrients and contaminants, alone or together, alter the epigenetic patterns in Atlantic cod, A. salmon and in h umans. Diets for aquacultured species are now based on plant ingredients. With plant proteins, it is likely that the one-carbon cycle is affected and possibly also the DNA methylation. Omega-6 levels increases with the use of plant oils and tilt the balan ce between omega-3 and -6 fatty acids. These are essential but have different effects on health and development. Therefore, zebrafish will be fed diets with either low levels of B-vitamins and methionine or with high levels of omega-6 fatty acids and be a  model for the epigenetic changes driven by these nutrients. Based on this, analysis of samples from life cycle experiments (A. cod and A. salmon), running in other projects. A good nutritional status ameliorates several effects of contaminants, but the m echanisms behind is largely unknown. Epigenetics is likely to be one. A feeding trial with A. salmon juveniles will be done with diets spiked with methyl donors and co-factors in the one-carbon cycle (i.e. B5, B6 and B12). These will then be exposed to ne w and emerging toxicants (in feeds and feedstuffs for aquaculture, like pesticides) through their diet to elucidate how an optimal diet can produce a fish with higher resilience. The choice of contaminants will be based on a screen using zebrafish embryos /larvae exposed to a set of emerging toxicants (in accordance with considerations from EFSA).   Seafood consumers get both methylmercury (MeHg) and omega-3 fatty acids (n-3PUFAs). n-3PUFAs have been shown to ameliorate the effects of contaminants. Data ob tained by analysing epigenetic patterns in human samples, correlated to the intake of seafood and the levels of MeHg, will be the basis for experimental studies using zebrafish focusing on neural development.

0 antall prosjekter

SIPHINIFES-SIP ved HI

Inheritance of epigenetic patterns under the influence of diets and contaminants

Tildelt: kr 16,0 mill.

Prosjektperiode: 2013-2018

Sted: Vestland