Tilbake til søkeresultatene

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Effects of marine dietary supplements on lesion formation and vascular inflammation in apolipoprotein E-deficient mice

Tildelt: kr 3,4 mill.

With the development of the apolipoprotein E-knockout mouse, a transgenic animal model became available, where atherosclerotic lesions that have striking similarities to the human disease, develop spontaneously. This model has proven very useful in studyi ng biochemical and cellular events leading to several aspects of atherosclerosis such as initiation, progression, growth arrest, and regression. In the present study, this mouse model will be applied to gain more knowledge on the effects of feeding mice w ith marine oils (refined/cold pressed), shellfish and shrimp hydrolysates on atherosclerotic plaque formation, other atherothrombotic mechanisms and the cellular and biochemical processes involved. The specific aim of this study was to obtain new insights in (1) the ability of these marine products to suppress atherogenesis, in (2) whether the processing of the marine products interferes with any observed effects, and in (3) the pathways involved in development of atherothrombotic diseases.

Budsjettformål:

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Temaer og emner

Ingen temaer knyttet til prosjektet