Energy Balance and Breast Cancer Aspects. A randomised clinical trial with physical activity interventio

Breast cancer requires intense and prolonged treatments often associated with significant side effects, also influencing their levels of physical activity after diagnosis. New evidence from large cohort studies supports a role of physical activity in redu cing recurrence and improving survival. According to current conceptions of breast cancer etiology and progression of the disease, metabolic profiles and ovarian steroids play a potentially important role at every stage of the disease process from the ini tial transformation of cells to the progress of disease post diagnosis. Physical activity affects several of these specific biological processes in volved. Energy Balance and Breast Cancer Aspects study will have a prospective two-arm randomized design comparing physical activity vs control. Women newly diagnosed with breast cancer at the Ullevaal University Hospital, will be invited to participate. Eligible women will be randomised to an intervention group (physical active group) or a control group (st andard care). A senior consultant in oncology will follow the patients throughout the study. We will use a modifiied intervention program. The intervention group will receive a detailed training program modified for them at start with 15 minutes x 3/week, increasing to 45 minutes per session for 12 month. Patients will wear an accelerometer for a week at baseline and follow-up visits to assess physical activity level objectively Measurements will be performed among the participating patients. Patients wil l be followed annually after 12 month for additional 5 years. If such a trial demonstrates that physical activity influence metabolic profile and are of importance for breast cancer recurrence, physical activity should be prescribed as an integral part o f breast cancer therapy. We aim at publishing the new results in the most prestigious journals within the field.