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FRIMEDBIO-Fri prosj.st. med.,helse,biol

The Nordic-European Initiative on Colorectal Cancer (NordICC)

Tildelt: kr 13,8 mill.

Prosjektnummer:

197309

Søknadstype:

Prosjektperiode:

2010 - 2015

Geografi:

Colorectal cancer (CRC) is a major burden in western countries. The disease develops from precursor lesions. Colonoscopy can detect and remove CRC precursor lesions and may thus be effective for CRC prevention. According to European Union guidelines, evid ence from randomised trials to reduce incidence or mortality of the target disease is a prerequisite before advocating population-wide cancer screening. However, while colonoscopy screening for the prevention of colorectal cancer is established in several European countries and the United States, no randomised trials exist to quantify the possible benefit of colonoscopy screening. NordICC is a multicentre, randomised trial in Norway, Sweden, Iceland, the Netherlands and Poland. A minimum of 72 000 indiv iduals, age 55-64 years, are drawn randomly from the population registries in the participating countries. 24 000 are invited for once-only colonoscopy. Expected work-load with 50% compliance will be 12,000 colonoscopies. The remaining 48 000 individuals (control group) are not offered any screening examination.The primary study aims are CRC incidence and CRC mortality after 15 years of follow-up. The study is powered to show a risk reduction of CRC mortality of 25% in the colonoscopy screening group comp ared to the control group in an intention-to-treat approach, estimating 50% compliance in the screening group. The administrative and scientific lead of the NordICC trial including the study database is situated at the Cancer Registry of Norway. Grants f rom the Polish and Dutch governments cover 7,500 colonoscopies performed in these respective countries starting in May 2009. Additional grant proposals (including the present one) are submitted to finance the additionally needed colonoscopies. NordICC i s the first randomised trial to investigate the effect of colonoscopy on CRC incidence and mortality. The NordICC group comprises world-leading experts in the field and is chaired by Norwegian researchers.

Budsjettformål:

FRIMEDBIO-Fri prosj.st. med.,helse,biol

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