Tilbake til søkeresultatene

HAVBRUK2-Stort program for havbruksforskning

Mammalian B-1 cells - an evolutionary descendant of teleost IgM B cells?

Tildelt: kr 0,35 mill.

Although vaccination provide critical defense against many pathogens that are threatening farmed Atlantic salmon (Salmo salar L.), infectious diseases still have a negative impact on fish welfare and especially viral diseases are a main concern since the current vaccines only provide suboptimal protection. The vaccines in use today are based on inactivated pathogens. They work through induction of antibodies by B cells, that aim to block infection or interfere with viral invasion of the bloodstream. The components and mechanisms underlying formation of and function of A. salmon B cells are elusive. However, at the moment two ongoing research projects in our group are aiming at resolving some of the issues related to A.salmon B cell biology and IgM antibody responses. Here we apply for funding of a 10 month stay in the lab of Professor Nicole Baumgarth, UC Davis, USA. Her work focuses in particular on the B-1 cell subset in mice, which clearly shares properties with B cells of more ancient vertebrates such as teleost fish. However, for A. salmon fundamental knowledge on B cells is completely lacking. To start filling this knowledge gap and expand the methodologies used for A.salmon, learning from research of mice B-1 cells is initiated in this project through international collaboration. This project aims at exploring B-1 responses in mice and taking advantage of this highly relevant knowledge in ongoing research projects on B cell immunity in A.salmon.

Budsjettformål:

HAVBRUK2-Stort program for havbruksforskning