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BIONÆR-Bionæringsprogram
Public health aspects and the relationship between Shiga toxin-producing and Enteropathogenic E. coli in the ruminant food production chain
Tildelt: kr 10,1 mill.
Kilde:
Prosjektleder:
Prosjektnummer:
178161
Søknadstype:
Prosjektperiode:
2007 - 2014
Midlene er mottatt fra:
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During the human E. coli O103 outbreak in 2006, isolated E. coli O103 without toxin genes (EPEC O103) showed very similar genetic profiles as the human isolates. However, EPEC O103 were isolated from a variety of sheep products from various industrial est ablishments and many of these could not be epidemiologically linked to the human cases, indicating an unknown ubiquitous sheep reservoir of EPEC O103 or an unexpected high prevalence of extremely unstable toxin-producing O103 (STEC). The relationship betw een ruminant EPEC and STEC is unclear and what risk a possible ubiquitous EPEC reservoir represents for generating new human pathogenic STEC is unknown. Another plausible explanation for the extensive sheep product contamination is bacterial dissemination from biofilms in the industrial establishments.
In order to give quick and reliable answers to diagnostic problems, routine microbiological screening methods for the isolation and detection of the E. coli serogroups most associated with human STEC infect ions will be developed and optimized.
Secondly, to distinguish between potentially human pathogenic and other E. coli, various virulence factors of E. coli variants from different sources will be studied and characterized and microarray techniques will be used for strain comparison and detection of known and putative virulence factors to predict human pathogenicity. MLVA as a microbial typing method of E. coli variants and thereby identify human pathogens will be examined.
Biofilm forming ability and comp osition of biofilm matrix of different E. coli isolates will be studied in order to determine their ability to persist in food production factories and retail shops. The pathogenic potential of phage transduction in biofilm will be elucidated and the effe ct of different disinfectants on biofilm forming E. coli will be examined. Possible biofilm-inhibiting abilities of furanones will be tested as such furanones may prove to be the disinfectants of the future.
Publikasjoner hentet fra Cristin
Synthetic brominated furanone F202 prevents biofilm formation by potentially human pathogenic Escherichia coli O103: H2 and Salmonella ser. Agona on abiotic surfaces
Occurrence of Potentially Human-Pathogenic Escherichia coli O103 in Norwegian Sheep
Potentially pathogenic E. coli can produce biofilm under conditions relevant for the food production chain
Biofilm as an Environment for Dissemination of stx Genes by Transduction
Biofilm – et miljø for spredning av farlige gener
Biofilm- naturlig bekjempelse
The effect of polyamines on biofilm formation by Salmonella and E. coli
Potentially pathogenic E. coli can produce biofilm under conditions relevant for the food production chain
Dissemination of stx genes in E. coli biofilm
Bakterienes hemmelige liv
Biofilm-egenskaper hos zoonotiske E. coli
Ingen publikasjoner funnet
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BIONÆR-Bionæringsprogram
3,1MRD. KRtotalt tildelt i programperioden716PROSJEKTERhar fått tildeling i programperioden6KILDERhar finansiert programmet
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