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Om Prosjektbanken

2022

Trøndelag - Trööndelage

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LTP3 Styrket konkurransekraft og innovasjonsevne

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Horizon 2020 Framework Programme

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EURATOM

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SME instrument phase 2

ERA-NET Cofund

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Utviklingsarbeid

Verifisering, pilotering, demonstrasjon (ny fra 2014)

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EOSC Beyond: advancing innovation and collaboration for research

EOSC Beyond overall objective is to advance Open Science and innovation in research in the context of the European Open Science Cloud (EOSC) by providing new EOSC Core capabilities allowing scientific applications to find, compose and access multiple Open Science resources and offer them as integrated capabilities to researchers. To do so, EOSC Beyond supports a new concept of EOSC: a federated and integrated network of Nodes operated at different levels, national, regional, international and thematic, to serve the specific scientific missions of their stakeholders. Further specific objectives of the project are to accelerate ‘time to product’ of new scientific applications with software adapters, enable Open Science with machine composability and dynamic deployment of shared resources, support innovation in EOSC with a testing and integration environment, and align the EOSC Core architecture and specifications to integrate with European dataspaces. The project extends the state of the art of the EOSC Core and adopts a co-design methodology, including requirements elicitation, software development and validation in collaboration with different use cases from EOSC national and regional initiatives (e-Infra CZ, Czechia, NFDI, Germany, and NI4OS, South East Europe region), thematic research infrastructures from Social Sciences and Humanities (CESSDA), Life Sciences (CNB-CSIC and Instruct-ERIC), Environmental Science (ENES and LifeWatch), and Health and Food (METROFood-RI). EOSC Beyond builds on the capacities of prospective EOSC Nodes and partners with multi-annual experience in developing solutions for large-scale federated digital infrastructures and aligns with the technical architecture and requirements of data spaces from different business sectors. Ultimately, EOSC Beyond supports Open Science in modern, data-intensive, and multidisciplinary research, facilitating resource discovery, access, and reuse across scientific communities, organisations, and countries. 

CULTUral heritage in RurAL remote areas for creative tourism and sustainabilITY

The main objective of the project is to contribute to the promotion of cultural and creative tourism activities, considering the different capacities, resources, and specificities (material, creative, human...) of the territories, as a mean to help with the sustainable development of peripheral rural areas, favoring job creation and population settlement. For this, the potential of its cultural heritage will be researched, taking into account both the artisan material culture (techniques, materials, patterns and decorative elements), as well as the intangible culture (music, oral knowledge and culinary traditions) as a resource.   To promote non-seasonal tourism as a form of sustainable development with a stable population settlement we are going to research the crafts linked to the territory and their implications, but we will also carry out a documentation of the productive processes. First and foremost, we are going to cater to the necessities of the local communities and pay attention to aspects related to societal groups at risk of exclusion, such as women, the elderly and the youth.  All this will be developed from a multidisciplinary perspective, for which we will count on the various teams —most of them linked to different countries— that will be part of the consortium. Each of these partners will contribute to the development, as well as to the final result of the project through input directly related to their area of ??expertise: for example, among the collaborators we have intellectual teams specialized in the digitalization of heritage, research, or communication and dissemination, as well as as various institutions that will act as a testing ground for the more practical parts of the proposal. However, if something will characterize our work, it will be the constant collaboration between all parties, as well as the exchange of advice and experiences that will help to enrich collective knowledge and guarantee optimal results.

AQUASERV – RESEARCH INFRASTRUCTURE SERVICES FOR SUSTAINABLE AQUACULTURE, FISHERIES AND THE BLUE ECONOMY

The overarching objectives of AQUASERV are to bring together, enhance, integrate and customise RI capacities (including facilities, instruments and expertise) and through the provision of transnational access (on-site or remote) and/or virtual access, to significantly further scientific advance and promote and facilitate the implementation of European Common Fisheries Policy, the Farm to Fork Strategy, the Sustainable Blue Economy and the European Green Deal.   AQUASERV will achieve these objectives by offering scientists from academia and business remote and on-site transnational (TA) and virtual (VA) access to an advanced set of European research infrastructures and its nodes related to research and management of marine and freshwater biological resources, food and biotechnology. These include the European Marine Biological Resource Centre ERIC (EMBRC), the Analysis and Experimentation on Ecosystems ERIC, The Aquaculture for Excellence for Aquaculture in Fish (Aquaexcel), and the Infrastructure for Promoting Metrology in Food and Nutrition (METROFOOD), as well as the International Council for Exploration of the Sea, both a service provider and stakeholder. It also includes the Research Infrastructure for Science and Innovation Policy Studies (RISIS) to bring contributions from the social sciences and to bring results nearer to policy makers ensuring societal impact.   To enhance, integrate and customise RI capacities, collaboration between partners and new pipelines to meet the objectives of the project will be developed during the first 3 years and will make available  to users.  To ensure these capacities will not be lost, a sustainability work package involving stakeholders will address the project legacy.    To maximize impact, AQUASERV will build a communication network among the partnership and develop a dissemination and outreach programme. Furthermore, an advanced training programme will be developed to capture future users and will be updated during the p

Harmonization of Advanced Materials Ecosystems serving strategic Innovation Markets to pave the way to a Digital Materials & Product Passport

The overarching objective of DigiPass is to enhance the digital maturity of the European communities that develop materials and intermediate products. The project will develop recommendations and clear routes toward digitalized circular business models. The overarching key result of DigiPass is to create a sustainable platform which includes support for Digital Materials & Product Passport and for collaborative innovation-by-design processes in a circular economy served by advanced materials. A business model for operating such a platform completes the overarching objective. DigiPass is harmonizing and synergizing collected materials data sources and digital infrastructures. This will enable interoperability of data exchange, and standardization of advanced materials knowledge representation at all maturity levels. Accelerating the design, development, and production of advanced, safe, and sustainable chemicals and materials, as they are necessary for innovative products, calls for a collaborative approach involving different stakeholders to support durability, repair and overhaul, reuse, and recyclability of products. DigiPass project impacts all materials development communities over the whole circular value chain.  

EOSC-ENTRUST: A European Network of TRUSTed research environments

The mission of EOSC-ENTRUST is to create a European network of trusted research environments for sensitive data and to drive European interoperability by joint development of a common blueprint for federated data access and analysis.  Countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policy-driven analysis of sensitive datasets such as people's health and socio-economic status, the habitats of vulnerable species and geo-spatial locations of protected sites. There are now a large number of such secure environments in operation - linked to national centres, individual organisations or specific research communities. This fragmented landscape poses challenges for both users and providers: researchers are faced with a large number of different systems and access procedures; providers need to manage federated access across multiple, potentially incompatible, technology and governance frameworks. EOSC-ENTRUST brings together providers of operational Trusted Research Environments from 15 European countries with a shared goal to implement, validate and promote their capabilities through a common European framework using shared standards and common legal, operational and technical language. This blueprint for interoperability is anchored in the EOSC Interoperability Framework spanning the four dimensions of Legal, Organisational, Technical and Semantic interoperability. EOSC-ENTRUST has identified four driver projects covering Genomics, Clinical trials, Social science, and public-private partnerships to benchmark capabilities, inform blueprint design and demonstrate secure  data analysis using federated workflows. Targeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a long-term operational TRE framework within the European Open Science Cloud. 

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Strengthening resilience and mental wellbeing through the Support4Resilience toolbox for leaders in elderly care

European elderly care experiences labor shortages, lack of qualified workers and a mismatch between capacity and demands, causing stress, burnout, and reduced mental wellbeing among healthcare workers and informal caregivers. Leaders are crucial in promoting supportive working conditions but lack research-based measures to act upon these challenges.  Support4Resilience (S4R) will develop, implement, and evaluate a research-based Toolbox to support healthcare leaders in improving healthcare workers’ and informal caregivers’ resilience and mental wellbeing in elderly care. S4R will identify resilience and mental wellbeing factors among healthcare workers and informal caregivers; explore their perspectives and needs; develop new theory on the relationship between individual and organizational resilience, and mental wellbeing; and develop recommendations and cost-effective interventions. The Toolbox with tailormade resources for policy and practical use will be available through an open access S4R Resource Bank.  The S4R Toolbox includes three main tools: 1) Mapping and identification, 2) Reflection and education, and 3) Reorganization. Measures are initiated at the organizational level and effects on mental wellbeing and resilience transpire at the frontline of elderly care. The Toolbox covers different situational contexts, types of healthcare providers and health system levels. Elderly care settings in six European countries will implement and evaluate the Toolbox through a process evaluation, effectiveness evaluation, and cost-effectiveness evaluation.   S4R provides policymakers, decisions-makers and leaders with solutions for taking action to solve specific risks for healthcare workers’ and informal caregivers’ resilience and mental wellbeing. Thus, pertinent to the work programme, S4R will support the development of resilient health systems in European elderly care through improved leadership capabilities, governance structures, and adaptive capacities.

UNIVERSAL SENSOR BASED ON ELECTRICALLY-PUMPED MID-INFRARED SPECTROMETER ON SILICON CHIPS

High resolution optical spectroscopy in the mid-infrared (mid-IR) spectral range (3-12 µm wavelength) is an unambiguous way to detect and quantify small traces of greenhouse and toxic gases down to sensitivities of parts-per-billion. Such sensitivities are a prerequisite to safeguard low-pollution and toxic-free environment defined by the EU Action Plan: "Towards a Zero Pollution for Air, Water and Soil.” However, size, cost, and general complexity of the commercially available instruments limits their use to a small number of highly specialized applications, and prevents their deployment with sufficient coverage e.g. in networks, wearable electronics, etc. Particularly in the context of Internet of Things (IoT) devices, on chip integration of spectroscopic systems would constitute a game changer for mid-IR high-precision and portable sensors. The objective of UNISON is to address this challenge and demonstrate a highly scalable platform for infra-red spectroscopy that has both high-end performance and is compact. UNISON sensing scheme relies on dual comb spectrometers obtained by leveraging on electrically pumped cascade lasers (QCL and ICL) and on silicon-germanium (SiGe) mid-IR photonic circuits to surpass current spectroscopic systems in terms of detection bandwidth, point spacing and system compactness. UNISON is organized around 3 main cornerstones each of them relying on ambitious physical and technological challenges: (i) tunable large bandwidth frequency combs will be generated on SiGe photonics circuits  by combining electro-optical comb generation, non-linear effects and dispersion engineering ; (ii) the comb sources will be pumped by novel electrically-driven cascade laser sources integrated with the SiGe photonics circuits ; (iii) compact, broadband, and sensitive interaction region for trace gas detection, designed and optimized for the SiGe platform, will be integrated with the dual comb source to showcase the sensing capability of the spectrometer. 

Providing research infrastructure services to support Next Generation EU

This four-year project will harness outputs from key social science RIs in Europe and other reliable sources to support the aims of the ‘Next Generation EU’ programme and to inform EU youth policy. Virtual access will be provided to the outputs through special installations (portals) developed during the project. The core of the proposal is a set of existing research ‘services’, which will be re-purposed and customised to focus directly on the five themes: Make it Green; Make it Digital; Make it Healthy; Make it Strong; and Make it Equal.   For each area, the consortium will work collaboratively to produce seven sets of resources:  i)	A searchable inventory of relevant variables drawn from multiple cross-national datasets;   ii)	Analytical summaries, suitable for policy makers and analysts new to the field, as well as interactive resources available through the project portal;  iii)	Harmonised and merged extracts from these datasets that reduce the burden on analysts and increase sample sizes;  iv)	New data collected through the ESS’s established CRONOS web panel infrastructure. Eleven countries will field five waves of the panel, each one dedicated to a NextGenEU theme. Free and rapid access to the data will be available through the CRONOS portal alongside analytical summaries;  v)	In-person and virtual deliberative forums with young people (aged 18-34) in four countries covering the five Next Generation EU’ themes;  vi)	An educational tool (E-NextGen) channelling our data for use in classrooms and by the general public;  vii)	Comprehensive training materials related to all project outputs. 

Cooperation and AgReements enhancing Global interOperability for Aerosol, Cloud and Trace gas research infrastructures

The goal of CARGO-ACT is to deliver a clear roadmap for sustainable global cooperation between key ground-based aerosol, cloud and trace gas research infrastructures, each having invested in infrastructure and services to support their observing networks with a long-term perspective, with a view to consolidating into a sustainable global research infrastructure in the future. There is a strong desire for global integration from the research community, including weather, climate, and air quality monitoring and modelling,  and in particular from space agencies, since global networks of ground-based observations are an essential component complementing Earth Observation from space, providing calibration and validation of the remote sensing information collected by current and future satellite missions. The integration of the current ground-based networks, which may have different interests and priorities, requires cooperation and agreements at the global level, including engagement with relevant stakeholders. Their service provision is not limited to data services, but includes access to the measurement facilities, reference instruments, reference standards and laboratories, all of which are topics to be assessed in CARGO-ACT.    The specific objectives of CARGO-ACT are to, develop sustainable partnerships and decision making processes with relevant partners, demonstrate the benefits of converging interoperability and standards to stakeholders and the global research community, establish the mechanisms for providing  international access to distributed research infrastructures and develop a roadmap for upscaling towards an integrated global research infrastructure for aerosol, cloud and trace gases. 

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Midlene fra FINANSMARK-Finansmarkedet fordelt på fylker

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Prosjektleder

"Kvinner empowerment og privat økonomi"

A 3D printed, affordable myoelectrical prosthetic hand of personalizeable size for optimal comfort and functionality

The needs of prosthetic hand users are still widely unaddressed, with 1/5 of end-users giving up on prosthesis use altogether. Discomfort and poor functionality are key complaints of prosthesis end-users, with >75% considering their current prosthesis too heavy and too slow for daily use. Indeed, existing commercial alternatives fail to provide simultaneously: 1) control of prosthesis through myoelectrical sensing (i.e. sensing the remining muscles contraction to open/close the prosthesis grip and change its gesture), 2) advanced/precision gripping patterns and 3) competitive costs within reimbursable limits of several countries. In addition, competing myoelectric prosthetic hands are typically 20-75% heavier than the human hand, resulting in significant pain and discomfort from continuous daily use.  Hereto, the prosthetic hand from Hy5 relies in a unique design that uses a combination of pumps and valves allowing fingers to be moved independently by a single central pumping unit. This not only allows to significantly lower the complexity of the overall system architecture, but also enables advanced gripping functionalities and gesture freedom without significantly ramping the prosthesis cost. Moreover, highly optimized use of advanced materials and 3D printing allow to bring the prosthesis weight on pair with the human hand – addressing a key end-user priority for comfort.   The goal of HelpingHAND is to overcome the most prominent barriers associated to the market introduction of our disruptive prosthesis, including gathering data for its CE-labelling as well as wide demonstration to gather sound evidence to support a solid communication strategy to build market awareness and end-user trust. Hereto, the successful implementation of the present project will represent a significant business opportunity for Hy5, sustaining a very fast-paced growth over its first 5 years of commercialization. 

Innovative and Smart Printed Electronics based on Multifunctionalized Paper: from Smart Labelling to Point of Care Bioplatforms 

Being flexible, easily foldable and recyclable, paper as substrate and functional part of portable, wireless, and/or disposable electronic devices is emerging as a promising approach to develop sustainable electronics contributing to reduce the electronic waste. INNPAPER is a use-case driven project aiming at providing a configurable common electronic platform based on multifunctional paper. To develop innovative paper manufacturing approaches, including (Nano)cellulose functionalization, to generate paper with tailor-made properties (e.g. (super)hydrophobicity/philicity, conductivity, etc) at surface and bulk level will be the first key challenge of the project. Based on this progress, a configurable common platform comprising a variety of paper-based devices (printed battery, electrochromic display, antenna and hybrid electronic circuit), where the paper will act as substrate and active component, will be developed. The common platform will be the basis for the subsequent manufacturing of a variety of use-cases covering different industrial sectors, in particular packaging and Point of Care (PoC) assays (security, food traceability, medical). The paper-based platforms will be manufactured in existing printing and hybrid manufacturing pilot-lines located at the partners facilities, providing not only a high impact paper-based electronics business case but also an open-access pilot line network to the EU after the project. An eco-design strategy including sustainability and re-use issues will be implemented.  Exploitation and Business plan to ensure the profitable use of the pilot-lines in short and long term timescale and the commercialization of the resulting paper-based platforms will be elaborated. The accomplishment of the INNPAPER targets will support the EU industry in the emergence of internet of things, consolidating the paper making and wood-harvesting industries and positioning EU in the environmental management of electronic waste.

Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices

REFINE proposes a Regulatory Science Framework for the risk-benefit assessment of medical products and medical devices that are based on nanomedicines and biomaterials. The heart of our framework is the development of a product-specific Decision Support System that identifies the most efficient way to deliver the data required by regulation by the best-fitting methods. The decision tree will explicate the product’s specific regulatory challenges and the priorities of both missing data and missing methods to match these challenges. It will thus allow planning a cost-and time efficient strategy both for necessary measurements and for the advancement of methods. Our approach is aligned with the industrial R&D practice of stage gating. We will demonstrate the relevance of the framework for the most pressing regulatory challenges, which are: borderline products, nanosimilars, and products combining several functionalities. In order to do so, we will identify the regulatory challenges with Regulation Authorities from Europe and abroad, and design methods for tiered decision tree, guided by the latest scientific knowledge. We will study/predict physiological distribution of nanomedicines and biomaterials, as well as develop and validate new analytical or experimental methods and assays requested by the regulators. These latter development will be performed in a quality management system, ensuring the possible standardisation of our assays. REFINE will gather a wide community of stakeholders in regulation, industry, science, technology development, patients, and end-users, into a Consortium for the Advancement of Regulatory Science in Biomaterials and Nanomedicine.

Guided (Ultra)sonic Waves for High Performance Deepwater Pipeline Inspection

This project aims to develop and commercialise VERNE: A non-destructive testing (NDT) system that has the potential to revolutionise underwater inspection of tubular structures by achieving far greater inspection speed and precision compared to existing systems. As the majority of offshore Oil and Gas extraction assets have already exceeded their design lifetime, the need for decommissioning and/or substituting these assets becomes increasingly pressing. However, associated costs are enormous and it will cost nearly €20 billion over the next 10 years to remove around 80 platforms and their associated infrastructure. As asset owners strive to prolong asset lifetime while and minimise risk of catastrophic accidents, the greatest challenge is the inspection and maintenance of subsea structures like jacket foundations and pipelines. In underwater environments the high pressure, seawater and marine life (biofouling) obstruct maintenance operations and accelerate structure degradation. Subsea inspections are currently performed using Remotely Operated Vehicles carrying a payload of cameras, sensors and other equipment. VERNE will dramatically improve on their performance by combining ultrasound and acoustic testing that enable (i) the rapid scanning and defect mapping in a 100m radius around the inspection point and (ii) detailed and precise characterisation once defects are identified. VERNE’s technologies enable inspection of both external and internal surface of structures (e.g. pipelines) without the need to remove anti-corrosion coatings and/or biofouling. As such, VERNE will lead to significant cost savings for asset owners while providing a key competitive advantage to subsea service providers. As such, project partners Dacon and Nardoni anticipate a cumulative turnover of €31.468 million and profits of €19.3 million by Year 5 with a breakeven over the total budget in Year 2 and a ROI rate of 13:1 on EC’s grant.

Governing Nanotechnologies through societal engagement

GoNano has as its main objective to improve the responsiveness of research & innovation processes to public values and concerns. The project builds on previous projects in public engagement and new technologies to develop a pilot project in each of the nanotechnology research areas ‘Health’, ‘Energy’ and ‘Food’. The pilot projects will engage citizens with researchers, professional users, civil society organisations, industry, and policy makers in a continuous process of deliberative workshops and online consultations to co-create concrete suggestions for future nanotechnologies. GoNano will build a broad community of ‘change agents’ for integrating an ‘RRI way’ of working on research and innovation, and it will develop and disseminate an RRI business case to align public values, needs and concerns with industry’ for profit ambition. GoNano builds on the basic assumption that several types of knowledge are needed to define sustainability, acceptability, and desirability of nanotechnologies, as well as the belief that online and offline engagement activities must be combined with a creative approach to dissemination and communication to ensure continued interest and engagement in the debate on nanotechnologies future application. GoNano believes that its interactive and open approach to: developing the nanotechnology product suggestion; writing policy recommendation and building an RRI business case; informing and educating about nanotechnology as well as the value of co-creation will build trust and mutual understanding among all the stakeholders, including public and private stakeholders and citizens.

Commercialising Innovative and Market Disruptive Pin Technology for Improving Heavy Machine Operations in Port, Mining and Construction Industries. Phase 1.

Bondura Technology (BT) manufactures tailored pin tool solutions. Pin type tools are used in all types of machinery to hold two joints together but allowing each its movement – they are part of the global market for Industrial Fasteners worth €64.9b in 2016. BT designs and manufactures market-disrupting pins that reduce heavy machinery downtime and maintenance costs. We have been operating within the offshore industry for 30 years, but driven by client and market demand we have designed and tested a new prototype with a Liebherr tower crane for use in port, mining and construction industries (TRL7). Therefore, we wish to undertake a thorough market and economic feasibility study to expand the use of our technology into new markets.  Our prototype is tapered at each end and these tapered cone sleeves expand upon tightening. This technology differs from standard solutions in that it uses a larger degree of assembly tolerance due to the expanding construction. Thus, the pin gets fixed to the equipment giving an extremely solid connection that avoids wear. Standard solutions (99% of the market) allow for exertion of lateral pressure during the independent movements of joints, causing them to wear out. This causes slackness, vibration and in the end, reduced safety, durability and performance. Our solution is disrupting in the new target markets since currently there is not similar available solution. This will be the only solution with 0 degrees of tolerance, and will be available at a price competitive, while our technology combats the degradation of assets, increases the lifecycle of equipment and significantly reduces downtime and maintenance costs.  We propose a Feasibility Study to verify our objective of expanding the usage of our technology within the heavy machinery segment via an investigation of market opportunities. Moreover, BTPin project is an opportunity to strengthen our innovation leadership by filing new IP.

Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts

The incidence of Cardiovascular Disease (CD) claims worldwide 17.1 million lives a year, with an estimated 31% of all deaths globally and a EU cost of 139 billion euros. Up to 40% of all deaths occur among the elderly. In spite of all medical efforts, the 5-year mortality was reduced significantly less than that of malignant diseases. This highlights the urgent need to overcome the difficulties associated with present pharmacological therapies (i.e. drug instability, and unspecific targeting) by developing new ground-breaking therapeutic strategies that go far beyond any current regimens. New approaches for safe, efficient, and heart-specific delivery of therapeutics are strongly required. CUPIDO is envisioned to meet these critical needs by providing an unconventional and effective strategy based on nanoparticle-assisted delivery of clinically available and novel therapeutics to the diseased heart. In particular, CUPIDO will develop innovative bioinspired hybrid nanoparticles formulated as biologicals delivery, which are i) biocompatible and biodegradable, ii) designed for crossing biological barriers, and iii) guidable to the heart. A combination of multidisciplinary manufacturing and validation approaches will be employed, bringing the envisioned product beyond the currently available clinical and day-to-day management of CD individuals. Scale-up production,  and respect of medical regulatory requirements will allow CUPIDO to deliver a final product for future late pre-clinical and clinical studies. Altogether, CUPIDO will foster the translation of nanomedical applications toward the cardiac field, which although still in its start, offers great potential to overcome the limitations associated to the currently pharmacological treatments. 

Pilot line production of functional polymer nanocomposites from natural halloysite nanotubes: demonstrating controlled release of active antimicrobials in food packaging applications.

NanoPack will demonstrate a solution for extending food shelf life by using novel smart antimicrobial surfaces, applied in active food packaging products. It will run pilot lines in operational industrial environments to manufacture commercially feasible antimicrobial polymer films, accepted by consumers. It will minimize the amount of preservatives required to maintain freshness, add value and assure safety to the entire supply chain. The project will employ natural Halloysite Nanotubes (HNTs) as reliable and safe carriers of bio-active compounds which are unable to migrate from the food packaging into food. Maximising safety, they slowly release minute amounts of potent, volatile and broad-spectrum natural agents into the packaging headspace. Using nanotechnology enables 1) introducing sensitive molecules into polymer films; 2) anti-microbial functionality without impaired film properties; 3) manufacturing potent antimicrobial surfaces with tunable properties, while creating a pH-triggered "gate keeper” effect to slow down release of the payload encapsulated. The resulting film will exhibit antimicrobial properties unmet by the current state-of-the-art. The processes across the supply chain will be validated through 5 pilot runs on existing production lines: 1) loading antimicrobials, 2) anti-microbial HNT polymer production, 3) anti-microbial packaging film production and 4-5) using the novel packaging on food products. Commercial feasibility will be assessed, including consumer acceptance and legal, regulatory, safety and environmental aspects.  The success of NanoPack will result in validated consumer-accepted nanotechnology-based antimicrobial food packaging that will enhance food safety, prevent foodborne illness outbreaks and reduce food waste caused by early spoilage. Better performing, safer and ‘smarter’ products will position Europe as the leader in food nanotechnology & smart antimicrobial packaging while increasing competitiveness and industry growth.

Brain-Specific, Modular and Active RNA Therapeutics

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases.   I.	To design modular nanoparticles consisting of  o	an active RNA payload o	established (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular vesicle-based) nanoparticles o	a targeting ligand  consisting of the variable domain of heavy chain only antibodies (also known as VHHs or nanobodies), which are coupled to the carrier platform  II.	To manufacture the modular nanoparticles using a microfluidic assembly system that will ensure quality-by-design: uniform nanoparticles across research sites and excellent control over the physico-chemical parameters.    III.	To test pre-clinical activity of formulations with promising in vitro activity with good cell/blood compatibility and to select the best RNA-formulation for clinical translation to treat neurodegenerative diseases. Pre-clinical efficacy is tested after o    local injection  o    nasal administration o    systemic administration The neurodegenerative diseases carry a high burden for patients since they are without exception progressive. But they also carry a substantial socio-economic burden with estimated costs of 130 billion euro. per year (2008).  IV.	The technical work in B-SMART will be supported by project management. It ensures that the project is coordinated in a clear, unambiguous and mutually acceptable manner and that the project achieves its objectives, within the given financial and time constraints.  in B-SMART we expect to arrive at a scale-able nanoparticle formulation with uniform characteristics that shows strong pre-clinical evidence of therapeutic efficacy and is ready for clinical translation. 

New generation wear and corrosion coating enabling European industry growth

The objective of ThermaSiC is to commercialise and bring to market our disruptive coating based on Silicon Carbide (SiC). ThermaSiC is the first in the world to enable SiC coating formation by thermal spraying - a major advancement on the current SoA-technology providing unique chemical-physical properties and superior coating performance in corrosive and harsh environments at high temperatures (up to 1,500°C in air). ThermaSiC will significantly increase the functional lifetime, lower weight, reduce maintenance and increase the performance of a wide range of engineering products – creating a significant market pull by end-users. SC is a spinout company from NTNU where our prototype coating technology was developed. Our Phase I-type Feasibility Study is based on a successful commercialisation process by NTNU validating both the technical capability (IP/ manufacturing) and market confirmation (done by Qittitut Consulting LLC). We have a highly specialised team of 7employees with world-leading skills within material science and engineering, business and production ramp-up combinedwith a professional Board of Directors for business strategy and a strong investor network. We have created 5 sequential and quantifiable Commercialisation Objectives focusing on overcoming the remaining barriers hampering successful commercialisation: 1. Technology maturation, elevating our current prototype technology from TRL6 to TRL8 (WP1) 2. End user piloting advancing ThermaSiC from TRL8 to TRL9 (WP2) 3. Supply chain development, up- and downstream (WP3) 4. Product exploitation strategy development, market research and post-project funding (WP4) 5. Innovation management and BIP development, IP management and stakeholder engagement (WP5) Through ThermaSiC we will significantly boost our growth - quantified as accumulated revenues exceeding EUR 808 million for the 5-years post project (2022) with accumulated gross profit of more than EUR 482 million and employment growth of 250 FTEs.

INitiative to bring the 2nd generation of ThermoElectric Generators into industrial ReALity

Thermoelectric materials have been studied for several decades now. Improved TE materials are emerging with the so-called second-generation thermoelectric (GEN2 TE) materials: silicides and half-Heusler. These materials are low-cost, based on most earth-abundant elements and eco-friendly materials, and can impact positively European industry and society by converting wasted heat into electricity.  As GEN2 TE materials are attracting a growing interest, pilot lines resulting from partnerships between public research institutes, industrial research teams and SME are emerging in Europe.  The aim of the INTEGRAL project is to upscale the GEN2 TE material technology using existing pilot lines and growing SMEs, in order to address mass markets TE needs (automotive, heavy duty trucks, autonomous sensors and industry waste heat recovery). The INTEGRAL project is unique since it gathers in a complete value chain the major companies (including SMEs and startups) developing GEN2 TE advanced materials in Europe and cutting-edge research centers. INTEGRAL will allow the industry to step up towards advanced manufacturing and commercialization of systems integrating multifunctional TE materials (on a nano-based approach), through material customization, next techniques for characterization and process control and up-scaled pilot-line demonstrations of reliability, reproducibility and mastered material consumption. Furthermore, the large-scale processes which will be developed for producing nanostructured materials within the INTEGRAL project will explore a wider range of applications outside thermoelectrics, in particular where customization of electrical or thermal properties of sintered or casted materials are needed. Finally, a technology transfer will be performed from research activities to pilot-lines, towards the commercialization of the new generation of advanced materials with a circular economy vision.  

Nanomedicine is the application of nanotechnology to medicine and healthcare. The field takes advantage of the physical, chemical and biological properties of materials at the nanometer scale to be used for a better understanding of the biological mechanisms of diseases at the molecular level, leading to new targets for earlier and more precise diagnostics and therapeutics. Nanomedicine, rated among the six most promising Key Enabling Technologies, is one of the most important emerging areas of health research expected to contribute to one of the strategic challenges that Europe has to face in the future: Provide effective and affordable health care and assure the wellbeing of an increasingly aged population.  EuroNanoMed III (ENM III) builds on the foundations of ENM I & II, which launched 7 successful joint calls for proposals since 2009, funded 51 transnational research projects involving 269 partners from 25 countries/regions, and allocated € 45,5 million to research projects from ENM funding agencies. ENM III consortium, reinforced with 12 new partners  from Europe, Canada and Taiwan, is committed to fostering the competiveness of European nanomedicine actors taking into account recent changes in the landscape and new stakeholders and challenges, as identified in the SRIA in nanomedicine. The first joint call for proposals will be co-funded by ENM III partners and the EC. After the co-funded call, three additional joint transnational calls will be organized and strategic activities will be accomplished in collaboration with key initiatives in the field. ENM III actions focus on translatability of project results to clinical and industry needs.      

ERA-NET ON NANOMEDICINE

Boronic acid hydrogel sensor for intravascular (arterial) blood glucose monitoring

The problem: Blood glucose levels in critically ill patients require close attention by the physicians and nurses in the intensive care units (ICU) because these patients spontaneously develop hyperglycaemia and increased variability of blood glucose. Unexpected drops in blood glucose are frequently caused by over-administration of insulin – exposing patient´s lives to dangerous hypoglycaemic episodes. These incidents increase the length of stay in ICUs and each bed day in an ICU has large direct costs around €1425.   The solution: GlucoSet is a novel dome-shaped hydrogel sensor that changes its volume and consequently its optical path length in the presence of glucose. The hydrogel tip is built at the end of thin optical fibres (125 µm), which enables GlucoSet to be the only technology small enough to pass through wrist arterial catheters, installed in most (up to 94%) ICU patients, without disturbing the blood pressure monitoring. GlucoSet has the potential to be the first real-time monitoring system for measuring glycaemia from arterial blood, which offer several advantages over central venous access such as higher accuracy and sensibility, less risk of interference from infusions, and much more convenient use.  The market: Critical care services face increasing demand worldwide – more particularly in the EU. With continuous increase in aging population in Europe along with life style related diseases, the number of critically ill patients needing accurate glucose monitoring in the ICUs will certainly rise. GlucoSet AS estimates a total market size of € 980 million per year for the intravascular continuous glucose monitoring, being the company in a strong position to exploit an addressable turnover exceeding € 115 million, five years after market introduction. Equally important, we estimate that the GlucoSet will allow savings of at least €2000 per patient in ICUs.  

High level Integrated SEnsor for NanoToxicity Screening

The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a screening tool for enhancing the efficiency of hazard profiling. Currently, no such flexible, easy-to-use screening platform with flexibly combinable chip-based sensors is available on the market.

A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.

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